Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude

Abstract

Intermittent hypoxia, initially associated with adverse effects of sleep apnea, has now metamorphosed into a module for improved sports performance. The regimen followed for improved sports performance is milder intermittent hypoxic training (IHT) as compared to chronic and severe intermittent hypoxia observed in sleep apnea. Although several studies have indicated the mechanism and enough data on physiological parameters altered by IH is available, proteome perturbations remain largely unknown. Altitude induced hypobaric hypoxia is known to require acclimatization as it causes systemic redox stress and inflammation in humans. In the present study, a short IHT regimen consisting of previously reported physiologically beneficial FIO2 levels of 13.5% and 12% was administered to human subjects. These subjects were then airlifted to altitude of 3500 m and their plasma proteome along with associated redox parameters were analyzed on days 4 and 7 of high altitude stay. We observed that redox stress and associated post-translational modifications, perturbed lipid metabolism and inflammatory signaling were induced by IHT exposure at Baseline. However, this caused activation of antioxidants, energy homeostasis mechanisms and anti-inflammatory responses during subsequent high-altitude exposure. Thus, we propose IHT as a beneficial non-pharmacological intervention that benefits individuals venturing to high altitude areas.

Comprehensive analysis of coding and non-coding RNA transcriptomes related to hypoxic adaptation in Tibetan chickens

“…Under hypoxic conditions, oxygen and carbon dioxide metabolism mainly depend on mitochondrial respiration and make use of adenosine triphosphate (ATP). Recently, a number of studies have shown the key regulatory role of energy metabolism, including glucose, carbohydrate, and lipid metabolic processes, among others, during hypoxic adaptation [ 52 – 55 ]. In the current research, from the constructed ceRNA network, we identified seven differentially expressed miRNAs (novel-miR-819, novel-miR-676, novel-miR-85, novel-miR-693, novel-miR-775, novel-miR-669, and novel-miR-867) and sixteen differentially expressed genes related to energy metabolism including glycosylation, glucose metabolism process, carbohydrate metabolism process, fatty acid metabolism, and ATP binding.…”

Comprehensive analysis of coding and non-coding RNA transcriptomes related to hypoxic adaptation in Tibetan chickens

“…Under hypoxic conditions, oxygen and carbon dioxide metabolism mainly depend on mitochondrial respiration and make use of adenosine triphosphate (ATP). Recently, a number of studies have shown the key regulatory role of energy metabolism, including glucose, carbohydrate, and lipid metabolic processes, among others, during hypoxic adaptation [52][53][54][55]. In the current research, from the constructed ceRNA network, we identi ed seven differentially expressed miRNAs (novel-miR-819, novel-miR-676, novel-miR-85, novel-miR-693, novel-miR-775, novel-miR-669, and novel-miR-867) and sixteen differentially expressed genes related to energy metabolism including glycosylation, glucose metabolism process, carbohydrate metabolism process, fatty acid metabolism, and ATP binding.…”

Comprehensive Analysis of Coding and Non-coding RNA Transcriptomes Related to Hypoxic Adaptation in Tibetan Chickens

“…Under hypoxic conditions, oxygen and carbon dioxide metabolism mainly depend on mitochondrial respiration and make use of adenosine triphosphate (ATP). At present, a number of studies have shown the key regulatory role of energy metabolism, including glucose, carbohydrate, and lipid metabolic processes, among others, during hypoxic adaptation [49][50][51][52]. In the current research, from the constructed ceRNA network, we identi ed seven differentially expressed miRNAs (novel-miR-819, novel-miR-676, novel-miR-85, novel-miR-693, novel-miR-775, novel-miR-669, and novel-miR-867) and sixteen differentially expressed mRNAs related to energy metabolism including glycosylation, glucose metabolism process, carbohydrate metabolism process, fatty acid metabolism, and ATP binding.…”