Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD

Burtscher, Martin; Haider, Thomas; Domej, Wolfgang; Linser, Tobias; Gatterer, Hannes; Faulhaber, Martin; Pocecco, Elena; Ehrenburg, Igor V.; Tkatchuk, E.; Koch, Robert; Bernardi, Luciano

doi:10.1016/j.resp.2008.10.012

Cited by 68 publications

(71 citation statements)

References 34 publications

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“…Rats and dogs subjected to these protocols showed no distress, and humans (including coauthor HFD) reported no discomfort. In other laboratories, human subjects with hypertension, 101 ischemic heart disease, 102,103 and chronic obstructive pulmonary disease 104 have completed similar protocols with no untoward effects. When intermittent hypoxia was produced in hypobaric chambers, daily hypoxic exposures were 4 h bouts at a simulated altitude of 4000 m for 14 days.…”

Section: Intermittent Hypoxic Training (Iht) Improves Cerebrovascularmentioning

confidence: 99%

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Манухина

Downey

Shi

et al. 2016

Exp Biol Med (Maywood)

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Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development. Although currently there are no definitive therapies for treatment or prevention of AD, reduction of VRFs lowers the risk for cognitive decline. There is increasing evidence that brief repeated exposures to moderate hypoxia, i.e. intermittent hypoxic training (IHT), improve cerebral vascular function and reduce VRFs including systemic hypertension, cardiac arrhythmias, and mental stress. In experimental AD, IHT nearly prevented endothelial dysfunction of both cerebral and extra-cerebral blood vessels, rarefaction of the brain vascular network, and the loss of neurons in the brain cortex. Associated with these vasoprotective effects, IHT improved memory and lessened AD pathology. IHT increases endothelial production of nitric oxide (NO), thereby increasing regional cerebral blood flow and augmenting the vaso-and neuroprotective effects of endothelial NO. On the other hand, in AD excessive production of NO in microglia, astrocytes, and cortical neurons generates neurotoxic peroxynitrite. IHT enhances storage of excessive NO in the form of S-nitrosothiols and dinitrosyl iron complexes. Oxidative stress plays a pivotal role in the pathogenesis of AD, and IHT reduces oxidative stress in a number of experimental pathologies. Beneficial effects of IHT in experimental neuropathologies other than AD, including dyscirculatory encephalopathy, ischemic stroke injury, audiogenic epilepsy, spinal cord injury, and alcohol withdrawal stress have also been reported. Further research on the potential benefits of IHT in AD and other brain pathologies is warranted.

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Section: Intermittent Hypoxic Training (Iht) Improves Cerebrovascularmentioning

confidence: 99%

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Манухина

Downey

Shi

et al. 2016

Exp Biol Med (Maywood)

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“…К настоящему времени проведено несколько иссле-дований, подтверждающих позитивные эффекты дли-тельного гипоксического прекондиционирования в ин-тервальном режиме в повышении переносимости физиче-ских нагрузок и коррекции кардиоваскулярных факторов риска как у здоровых лиц, так и у кардиологических боль-ных [2,16,17]. Проведение ИГТ в режиме цикличного че-редования периодов дозированной гипоксии и гиперок-сии является принципиально новой технологией повы-шения неспецифических адаптационных возможностей организма человека [1,6,11].…”

Section: Discussionunclassified

“…Детально результаты динамики толерантности к физическим нагрузкам пациентов с ИБС в курсе ИГГТ представлены нами отдельно [5]. Достигнутый результат сохранялся и через месяц после окончания курса процедур ИГГТ, что ранее не было предметом специального анализа в сходных клинических исследованиях [3,17]. Принципи-ально важным представляется факт параллельного улучше-ния практически у всех пациентов субъективного восприя-тия КЖ, что продемонстрировано в динамике значений субшкал болезнь-специфического опросника стенокардии SAQ, а также значений субшкал опросника SF-36, характе-ризующих физическое состояние субъективной оценки здоровья: ФА, РД и ЖС.…”

Section: Discussionunclassified

Quality of life in patients with stable angina in application of intermittent hypoxic-hyperoxic training

Загайная¹,

Копылов²,

Zagaynaya³

et al. 2016

Kardiol. serdechno-sosud. khir.

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“…Mais recentemente, alguns estudos têm buscado desvendar os efeitos da exposição à hipóxia intermitente (HI), objetivando explorar o valor terapêutico em pacientes e a influência potencial no desempenho de atletas (NEUBAUER, 2001). Na medicina, a HI já foi aplicada em pacientes com doença pulmonar obstrutiva crônica (DPOC) (BURTSCHER et al, 2009), hipertensão, processos inflamatórios, doença de Parkinson, entre outras (SEREBROVSKAYA, 2002). Em animais, a HI mostrou ter efeito antiarrítmico em casos de isquemia aguda do miocárdio em ratos (MEERSON et al, 1987) e para proteger o miocárdio de cães com infarto experimentalmente induzido (ZONG et al, 2004).…”

Section: Introductionunclassified

Cortisol, resposta glicêmica e secreção de insulina em equinos clinicamente sadios submetidos a sessões de hipóxia normobárica

et al. 2011

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Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD

Cited by 68 publications

References 34 publications

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Quality of life in patients with stable angina in application of intermittent hypoxic-hyperoxic training

Cortisol, resposta glicêmica e secreção de insulina em equinos clinicamente sadios submetidos a sessões de hipóxia normobárica

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