Intermittent Hypoxia–Hyperoxia Conditioning Improves Cardiorespiratory Fitness in Older Comorbid Cardiac Outpatients Without Hematological Changes: A Randomized Controlled Trial

Дудник, Е. Н.; Zagaynaya, Elena; Глазачев, О. С.; Суста, Давиде

doi:10.1089/ham.2018.0014

Cited by 26 publications

(66 citation statements)

References 14 publications

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“…A recent study that evaluated the effects of IHHT on patients with MCI (64–92 years of age) has shown significant improvements in the cognitive state and physical endurance [37]. These findings were also in accordance with the study results from another research group [27,30].…”

Section: Discussionsupporting

confidence: 83%

“…There is growing evidence supporting the notion that sessions of brief repeated, controllable exposures to moderate levels of hypoxia, termed as intermittent hypoxia-normoxia training (IHT) or intermittent hypoxia-hyperoxia training (IHHT), may improve cerebral vascular function and mitochondrial energy production, same as those that have been demonstrated in sports training and/or rehabilitative medicine. For instance, IHT has beneficial effects on elderly health [27,28,29]. During the past decade, a modified intermittent hypoxia training method, i.e., IHHT, was introduced and applied in several human studies or clinical trials in several European countries [27,30,31].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, IHT has beneficial effects on elderly health [27,28,29]. During the past decade, a modified intermittent hypoxia training method, i.e., IHHT, was introduced and applied in several human studies or clinical trials in several European countries [27,30,31]. The underlying cellular mechanisms of IHT or IHHT may include the improvement of mitochondrial function, regulation of glucose transport, activation of antioxidant enzyme system, as well as anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

Serebrovska

Kholin

et al. 2019

IJMS

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Alzheimer’s disease (AD) affects not only the central nervous system, but also peripheral blood cells including neutrophils and platelets, which actively participate in pathogenesis of AD through a vicious cycle between platelets aggregation and production of excessive amyloid beta (Aβ). Platelets adhesion on amyloid plaques also increases the risk of cerebral microcirculation disorders. Moreover, activated platelets release soluble adhesion molecules that cause migration, adhesion/activation of neutrophils and formation of neutrophil extracellular traps (NETs), which may damage blood brain barrier and destroy brain parenchyma. The present study examined the effects of intermittent hypoxic-hyperoxic training (IHHT) on elderly patients with mild cognitive impairment (MCI), a precursor of AD. Twenty-one participants (age 51–74 years) were divided into three groups: Healthy Control (n = 7), MCI+Sham (n = 6), and MCI+IHHT (n = 8). IHHT was carried out five times per week for three weeks (total 15 sessions). Each IHHT session consisted of four cycles of 5-min hypoxia (12% FIO2) and 3-min hyperoxia (33% FIO2). Cognitive parameters, Aβ and amyloid precursor protein (APP) expression, microRNA 29, and long non-coding RNA in isolated platelets as well as NETs in peripheral blood were investigated. We found an initial decline in cognitive function indices in both MCI+Sham and MCI+IHHT groups and significant correlations between cognitive test scores and the levels of circulating biomarkers of AD. Whereas sham training led to no change in these parameters, IHHT resulted in the improvement in cognitive test scores, along with significant increase in APP ratio and decrease in Aβ expression and NETs formation one day after the end of three-week IHHT. Such effects on Aβ expression and NETs formation remained more pronounced one month after IHHT. In conclusion, our results from this pilot study suggested a potential utility of IHHT as a new non-pharmacological therapy to improve cognitive function in pre-AD patients and slow down the development of AD.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

Serebrovska

Kholin

et al. 2019

IJMS

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“…Согласно анализу данных, представленных в 11 отобранных публикациях, из 320 пациентов подавляющее большинство -пациенты пожилого возраста с сопутствующей артериальной гипертензией (АГ). После курса ИГГТ/ИГТ у пациентов отмечалось значимое снижение частоты сердечных сокращений, систолического артериального давления (АД) (САД) и диастолического АД по сравнению с контрольной группой [16][17][18][19]. Более того, показано, что курс гипоксической терапии сопровождается снижением уровня холестерина и липопротеидов низкой плотности, но без клинически значимой разницы [16,18,20].…”

Section: эффективность метода гипоксического кондиционирования в программах кардиореабилитацииunclassified

“…Более того, показано, что курс гипоксической терапии сопровождается снижением уровня холестерина и липопротеидов низкой плотности, но без клинически значимой разницы [16,18,20]. С точки зрения гематологических параметров, таких как гемоглобин, эритроциты и ретикулоциты, значительного эффекта гипоксического воздействия не было [16,[18][19][20][21]. Значимой разницы пикового потребления кислорода между гипоксической и плацебо-группами к окончанию курса выявлено не было, однако в ряде работ был продемонстирован достоверно значимый прирост пикового потребления кислорода у пациентов гипоксической группы по сравнению с изначальным уровнем [16,18,19,21].…”

Section: эффективность метода гипоксического кондиционирования в программах кардиореабилитацииunclassified

Intermittent hypoxic conditioning: experience and potential in cardiac rehabilitation programs

Глазачев

Лямина

Spirina³

2021

Russ J Cardiol

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The review describes the experience in intermittent hypoxic conditioning protocols in rehabilitation programs for patients with cardiovascular diseases. Based on randomized controlled trials, the efficacy and safety of intermittent hypoxic conditioning in patients with cardiovascular disease, including those with multicomorbidity in clinical practice, have been analyzed. From a physiological and clinical standpoints, the review justifies the need for further controlled clinical trials on hypoxic conditioning with a longer follow-up period both to expand the clinical indications for this method and to develop optimal combinations with exercise within cardiac rehabilitation programs. Discovery of the key mechanisms of adaptation to oxygen concentration changes and further research on hypoxia physiology will expand the application of this method in clinical and rehabilitation medicine in cardiac patients.

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Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress

Ehrenreich¹,

Gassmann

Poustka

et al. 2023

Neuroprotection

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Hypoxia is increasingly recognized as an important physiological driving force. A specific transcriptional program, induced by a decrease in oxygen (O2) availability, for example, inspiratory hypoxia at high altitude, allows cells to adapt to lower O2 and limited energy metabolism. This transcriptional program is partly controlled by and partly independent of hypoxia‐inducible factors. Remarkably, this same transcriptional program is stimulated in the brain by extensive motor‐cognitive exercise, leading to a relative decrease in O2 supply, compared to the acutely augmented O2 requirement. We have coined the term “functional hypoxia” for this important demand‐responsive, relative reduction in O2 availability. Functional hypoxia seems to be critical for enduring adaptation to higher physiological challenge that includes substantial “brain hardware upgrade,” underlying advanced performance. Hypoxia‐induced erythropoietin expression in the brain likely plays a decisive role in these processes, which can be imitated by recombinant human erythropoietin treatment. This article review presents hints of how inspiratory O2 manipulations can potentially contribute to enhanced brain function. It thereby provides the ground for exploiting moderate inspiratory plus functional hypoxia to treat individuals with brain disease. Finally, it sketches a planned multistep pilot study in healthy volunteers and first patients, about to start, aiming at improved performance upon motor‐cognitive training under inspiratory hypoxia.

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Intermittent Hypoxia–Hyperoxia Conditioning Improves Cardiorespiratory Fitness in Older Comorbid Cardiac Outpatients Without Hematological Changes: A Randomized Controlled Trial

Cited by 26 publications

References 14 publications

RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

Intermittent hypoxic conditioning: experience and potential in cardiac rehabilitation programs

Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress

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