Intermittent high-volume predilution on-line haemofiltration versus standard intermittent haemodialysis in critically ill patients with acute kidney injury: a prospective randomized study

Abstract

Recent experiences in other fields of medicine show that more intensive treatment does not lead to better outcomes […] We may need to re-consider the value of careful monitoring and conservative treatment as a valid and independent option in the treatment of AKI.

Comparing Renal Replacement Therapy Modalities in Critically Ill Patients With Acute Kidney Injury: A Systematic Review and Network Meta-Analysis

“…The secondary analysis for length of ICU stay included seven interventions and 12 trials ( 4 , 27 – 29 , 31 , 35 , 36 , 40 – 42 , 49 , 51 ) with 2,024 patients ( Table 6 of ESM 6, http://links.lww.com/CCX/A591 ). Among the comparisons with high or moderate certainty evidence relative to CVVHDF, PD was most effective at reducing ICU length of stay, SLEDF was in the category of intermediate length of ICU stay, and CVVH and IHD were least effective at reducing ICU length of stay (Fig.…”

The Japanese clinical practice guideline for acute kidney injury 2016

“…However, there is insufficient evidence to establish this as the optimal hemofiltration dose for AKI. An RCT that compared HD and predilution on-line HF rather than HD doses was reported in 2012 [ 241 ]. The mean volume of infusate in predilution on-line HF was 81 L; the HF and HD groups did not demonstrate significant differences in their mortality or recovery of the renal function.…”

The Japanese Clinical Practice Guideline for acute kidney injury 2016

“…However, there is insufficient evidence to establish this as the optimal hemofiltration dose for AKI. An RCT that compared HD and predilution online HF rather than HD doses was reported in 2012 [ 239 ]. The mean volume of infusate in predilution online HF was 81 L; the HF and HD groups did not demonstrate significant differences in their mortality or recovery of the renal function.…”