Intermittent fasting protects the nigral dopaminergic neurons from MPTP-mediated dopaminergic neuronal injury in mice

Ojha, Uttam; Khanal, Shristi; Park, Pil-Hoon; Hong, Jin Tae; Choi, Dong‐Young

doi:10.1016/j.jnutbio.2022.109212

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…Exacerbated neuronal death and increased excitatory amino acids C57BL/6J mice treated with rotenone 28 days IF in combination with neurotoxin exposure led to increased neuronal death, excitatory amino acids, and inflammatory lipids [146].…”

Section: Parkinson's Diseasementioning

confidence: 99%

Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota

Guo,

Wang,

et al. 2023

Nutrients

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As the global population ages, the prevalence of neurodegenerative diseases is surging. These disorders have a multifaceted pathogenesis, entwined with genetic and environmental factors. Emerging research underscores the profound influence of diet on the development and progression of health conditions. Intermittent fasting (IF), a dietary pattern that is increasingly embraced and recommended, has demonstrated potential in improving neurophysiological functions and mitigating pathological injuries with few adverse effects. Although the precise mechanisms of IF’s beneficial impact are not yet completely understood, gut microbiota and their metabolites are believed to be pivotal in mediating these effects. This review endeavors to thoroughly examine current studies on the shifts in gut microbiota and metabolite profiles prompted by IF, and their possible consequences for neural health. It also highlights the significance of dietary strategies as a clinical consideration for those with neurological conditions.

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Section: Parkinson's Diseasementioning

confidence: 99%

Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota

Guo,

Wang,

et al. 2023

Nutrients

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“…In a MS animal model, IF reduced inflammation, increased bacteria richness in the gut and ameliorated the clinical course of the disease, which has also been shown in MS patients ( Cignarella et al, 2018 ). Similarly, in a mouse model of PD, IF attenuated dopaminergic neuron loss by upregulating neurotrophic factors and decreasing neuroinflammation ( Ojha et al, 2023 ).…”

Section: Risk and Protective Factors For Neuroinflammation In Neurode...mentioning

confidence: 99%

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Kip

Parr‐Brownlie

2023

Front. Neurosci.

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Since the mid-20th century, Western societies have considered productivity and economic outcomes are more important than focusing on people’s health and wellbeing. This focus has created lifestyles with high stress levels, associated with overconsumption of unhealthy foods and little exercise, which negatively affect people’s lives, and subsequently lead to the development of pathologies, including neurodegenerative and psychiatric disorders. Prioritizing a healthy lifestyle to maintain wellbeing may slow the onset or reduce the severity of pathologies. It is a win-win for everyone; for societies and for individuals. A balanced lifestyle is increasingly being adopted globally, with many doctors encouraging meditation and prescribing non-pharmaceutical interventions to treat depression. In psychiatric and neurodegenerative disorders, the inflammatory response system of the brain (neuroinflammation) is activated. Many risks factors are now known to be linked to neuroinflammation such as stress, pollution, and a high saturated and trans fat diet. On the other hand, many studies have linked healthy habits and anti-inflammatory products with lower levels of neuroinflammation and a reduced risk of neurodegenerative and psychiatric disorders. Sharing risk and protective factors is critical so that individuals can make informed choices that promote positive aging throughout their lifespan. Most strategies to manage neurodegenerative diseases are palliative because neurodegeneration has been progressing silently for decades before symptoms appear. Here, we focus on preventing neurodegenerative diseases by adopting an integrated “healthy” lifestyle approach. This review summarizes the role of neuroinflammation on risk and protective factors of neurodegenerative and psychiatric disorders.

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“…Accordingly, fasting-associated interventions may be targeting mitochondrial dysfunction and its downstream consequences rather than acting as a nutritional supplement, as it likely targets several physiological pathways. Thus fasting-associated interventions would appear feasible, effective, and inexpensive circadian-based treatments that are currently being tested in preclinical and clinical settings [ 94 – 96 , 101 , 102 ].…”

Section: Current Circadian Treatment Strategiesmentioning

confidence: 99%

Targeting sleep and the circadian system as a novel treatment strategy for Parkinson’s disease

Feigl,

Lewis,

Rawashdeh

2023

J Neurol

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There is a growing appreciation of the wide range of sleep–wake disturbances that occur frequently in Parkinson’s disease. These are known to be associated with a range of motor and non-motor symptoms and significantly impact not only on the quality of life of the patient, but also on their bed partner. The underlying causes for fragmented sleep and daytime somnolence are no doubt multifactorial but there is clear evidence for circadian disruption in Parkinson’s disease. This appears to be occurring not only as a result of the neuropathological changes that occur across a distributed neural network, but even down to the cellular level. Such observations indicate that circadian changes may in fact be a driver of neurodegeneration, as well as a cause for some of the sleep–wake symptoms observed in Parkinson’s disease. Thus, efforts are now required to evaluate approaches including the prescription of precision medicine to modulate photoreceptor activation ratios that reflect daylight inputs to the circadian pacemaker, the use of small molecules to target clock genes, the manipulation of orexin pathways that could help restore the circadian system, to offer novel symptomatic and novel disease modifying strategies.

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Intermittent fasting protects the nigral dopaminergic neurons from MPTP-mediated dopaminergic neuronal injury in mice

Cited by 6 publications

References 47 publications

Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota

Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Targeting sleep and the circadian system as a novel treatment strategy for Parkinson’s disease

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