Intermittent Fasting and Caloric Restriction: Neuroplasticity and Neurodegeneration

Vasconcelos, Andréa Rodrigues; Orellana, Ana Maria; Paixão, Amanda Galvão; Scavone, Cristóforo; Kawamoto, Elisa Mitiko

doi:10.1007/978-3-319-40007-5_99-1

Handbook of Famine, Starvation, and Nutrient Deprivation 2018

DOI: 10.1007/978-3-319-40007-5_99-1

|View full text |Cite

Intermittent Fasting and Caloric Restriction: Neuroplasticity and Neurodegeneration

Andréa Rodrigues Vasconcelos

Ana Maria Orellana

Amanda Galvão Paixão

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

2022

Publication Types

Select...

Article2

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CR is also linked to several whole animal-and molecular-level changes in physiology and behavior. These include increased hunger (5), cognitive performance (6), and autophagy (7), as well as reduced body temperature (8), blood glucose, insulin and insulin-like growth factor (IGF-1) levels (9), and oxidative stress (10). CR is also emerging as being protective against detrimental senescence and inflammatory senescence-associated secretory phenotype of cell populations implicated in aging (11).…”

mentioning

confidence: 99%

The Effects of Graded Levels of Calorie Restriction: XVIII.Tissue-Specific Changes in Cell Size and Number in Response to Calorie Restriction

Phillips

Mathers

Mitchell

et al. 2022

The Journals of Gerontology: Series A

View full text Add to dashboard Cite

Calorie restriction (CR) without malnutrition increases the health- and lifespan of diverse taxa. The mechanism(s) behind CR are debated but may be directly linked to body composition changes that maintain energy balance. During a deficit, energy is primarily obtained from white adipose tissue (WAT; utilized) whilst other tissues remain unchanged (protected) or grow (invested) relative to body mass. The changes in mass of 6 tissues from 48 male C57BL/6 mice following 3-months graded (10, 20, 30, or 40%) CR or fed ad libitum for 12 or 24hr a day were related to cell size (hypo/hypertrophy) and/or number (hypo/hyperplasia). Tissues studied were: retroperitoneal and subcutaneous WAT, brown adipose tissue (BAT) (utilized); lungs (protected), and stomach and caecum (invested). Methodology was based on number of nuclei/ tissue equalling the number of cells. Extracted DNA was quantified and used to estimate cell numbers (Total DNA/DNA per diploid nucleus) and size (Tissue mass/nuclei number). WAT utilization was caused solely by hypotrophy whereas BAT utilization resulted from reduced cell number and size. WAT cell size positively correlated with circulating hormones related to energy balance and BAT cell number and size positively correlated with body temperature. No changes were found in the lungs, consistent with their protected status, whereas hyperplasia appeared to be the dominant mechanism for invested alimentary-tract tissues. These findings indicate the pattern of change of cell size and number across increasing levels of short-term CR is tissue-specific.

show abstract

mentioning

confidence: 99%

The Effects of Graded Levels of Calorie Restriction: XVIII.Tissue-Specific Changes in Cell Size and Number in Response to Calorie Restriction

Phillips

Mathers

Mitchell

et al. 2022

The Journals of Gerontology: Series A

View full text Add to dashboard Cite

show abstract

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

2019

Self Cite

View full text Add to dashboard Cite

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the expression of an array of enzymes with important detoxifying and antioxidant functions. Current findings support the role of high levels of oxidative stress in the pathogenesis of neurological disorders. Given the central role played by Nrf2 in counteracting oxidative damage, a number of studies have targeted the modulation of this transcription factor in order to confer neuroprotection. Nrf2 activity is tightly regulated by oxidative stress and energy-based stimuli. Thus, many dietary interventions based on energy intake regulation, such as dietary energy restriction (DER) or high-fat diet (HFD), modulate Nrf2 with consequences for a variety of cellular processes that affect brain health. DER, by either restricting calorie intake or meal frequency, activates Nrf2 thereby triggering its protective effects, whilst HFD inhibit this pathway, thereby exacerbating oxidative stress. Consequently, DER protocols can be valuable strategies in the management of central nervous system (CNS) disorders. Herein, we review current knowledge of the role of Nrf2 signaling in neurological diseases, namely Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and cerebral ischemia, as well as the potential of energy intake regulation in the management of Nrf2 signaling.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Intermittent Fasting and Caloric Restriction: Neuroplasticity and Neurodegeneration

Cited by 2 publications

References 66 publications

The Effects of Graded Levels of Calorie Restriction: XVIII.Tissue-Specific Changes in Cell Size and Number in Response to Calorie Restriction

The Effects of Graded Levels of Calorie Restriction: XVIII.Tissue-Specific Changes in Cell Size and Number in Response to Calorie Restriction

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Contact Info

Product

Resources

About