Intermittent exposures to nanoTesla range, 7 Hz, amplitude-modulated magnetic fields increase regeneration rates in planarian

Gang, Noa; Parker, G. H.; Lafrenie, Robert M.; Persinger, Michael A.

doi:10.3109/09553002.2013.754554

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…There are researchers that treat decapitated planarians with weak nonuniform magnetic fields (RMFs) and found RMFs eliminated the formation of edema and blastema, which through upregulating the expression of EGR4, Netrin 2, NSE, and NPY accelerates nerve cell proliferation and function recovery [31][32][33]. The weak magnetic field stimulates the fission frequency of the Planarian Dugesia (Girardia) tigrina [32].…”

Section: Physiological Effects Of Altered Gravity and Magnetic Fieldmentioning

confidence: 99%

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Extreme Environmental Stress-Induced Biological Responses in the Planarian

Cao

Liu

Zhao

et al. 2020

BioMed Research International

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Planarians are bilaterally symmetric metazoans of the phylum Platyhelminthes. They have well-defined anteroposterior and dorsoventral axes and have a highly structured true brain which consists of all neural cell types and neuropeptides found in a vertebrate. Planarian flatworms are famous for their strong regenerative ability; they can easily regenerate any part of the body including the complete neoformation of a functional brain within a few days and can survive a series of extreme environmental stress. Nowadays, they are an emerging model system in the field of developmental, regenerative, and stem cell biology and have offered lots of helpful information for these realms. In this review, we will summarize the response of planarians to some typical environmental stress and hope to shed light on basic mechanisms of how organisms interact with extreme environmental stress and survive it, such as altered gravity, temperature, and oxygen, and this information will help researchers improve the design in future studies.

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Section: Physiological Effects Of Altered Gravity and Magnetic Fieldmentioning

confidence: 99%

“…Novikov et al [32], Gang et al [33]. Gang and Persinger [37] Intense magnetic field The planarian will suddenly die when it is over 6K.…”

Section: Weak Magnetic Fieldmentioning

confidence: 99%

Extreme Environmental Stress-Induced Biological Responses in the Planarian

Cao

Liu

Zhao

et al. 2020

BioMed Research International

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“…Two distinct physiological effects (i.e., regeneration rate and regeneration anomalies) on planarian regeneration have been shown when planarians were exposed to weak extremely low‐frequency (ELF) magnetic fields and weaker electromagnetic fields [Jenrow et al, ; Yamaguchi‐Sekino et al, ]. An intense magnetic field (nanoTesla range, 7 Hz) also induced a faster regeneration rate of photoreceptors and auricles in planarians compared to those of control groups [Gang et al, ]. However, to date there is no research concerning the effects of LG‐HMF on planarians.…”

Section: Introductionmentioning

confidence: 99%

Effects of large gradient high magnetic field (LG‐HMF) on the long‐term culture of aquatic organisms: Planarians example

Zhai

et al. 2018

Bioelectromagnetics

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Large gradient high magnetic field (LG-HMF) is a powerful tool to study the effects of altered gravity on organisms. In our study, a platform for the long-term culture of aquatic organisms was designed based on a special superconducting magnet with an LG-HMF, which can provide three apparent gravity levels (µ g, 1 g, and 2 g), along with a control condition on the ground. Planarians, Dugesia japonica, were head-amputated and cultured for 5 days in a platform for head reconstruction. After planarian head regeneration, all samples were taken out from the superconducting magnet for a behavioral test under geomagnetic field and normal gravity conditions. To analyze differences among the four groups, four aspects of the planarians were considered, including head regeneration rate, phototaxis response, locomotor velocity, and righting behavior. Data showed that there was no significant difference in the planarian head regeneration rate under simulated altered gravity. According to statistical analysis of the behavioral test, all of the groups had normal functioning of the phototaxis response, while the planarians that underwent head reconstruction under the microgravity environment had significantly slower locomotor velocity and spent more time in righting behavior. Furthermore, histological staining and immunohistochemistry results helped us reveal that the locomotor system of planarians was affected by the simulated microgravity environment. We further demonstrated that the circular muscle of the planarians was weakened (hematoxylin and eosin staining), and the epithelial cilia of the planarians were reduced (anti-acetylated tubulin staining) under the simulated microgravity environment. Bioelectromagnetics. 2018;39:428-440. © 2018 Wiley Periodicals, Inc.

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“…Therefore, the planarians are commonly used for the investigation of morphogenetic processes such as the wound healing, the regeneration, and the stem cells biology. Due to the high sensitivity of the processes of neoblasts proliferation and differentiation to the weak and ultra weak physical factors (magnetic fields) and to the low concentrations of chemical factors (hormones and neuromediators), planarians can serve as a convenient model organism for “in vivo” study of the biological mechanisms of LTAP impact at the cellular and whole organism level …”

Section: Introductionmentioning

confidence: 99%

The Effects of the Low Temperature Argon Plasma on Stem Cells Proliferation and Regeneration in Planarians

Ермаков

Ermakova

Skavulyak

et al. 2016

Plasma Processes & Polymers

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Effects of the low temperature argon plasma (LTAP) in intact and regenerating planarians are studied. The LTAP actions were specified as activating or inhibiting using stem cells proliferation and the regenerative blastema growth, and the expression level of woundspecific genes responsible for regeneration. The activating mode of LTAP treatment does not induce the generation of the Reactive Oxygen Species (ROS) but the inhibiting mode of LTAP treatment causes the oxidative stress response in planarian tissue without DNA damage. The results indicate that LTAP wound healing action in planarians could be similar in cellular and molecular mechanisms of the higher organisms including humans. The effects of LTAP irradiation as a factor of the low intensity are discussed from standpoint of the hormesis hypothesis.

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Intermittent exposures to nanoTesla range, 7 Hz, amplitude-modulated magnetic fields increase regeneration rates in planarian

Abstract: Naturally-patterned, intermittently-presented weaker electromagnetic fields may produce enhanced regeneration rates in flat worms similar to those observed for 60 Hz, higher intensity fields.

Cited by 3 publications

References 35 publications

Extreme Environmental Stress-Induced Biological Responses in the Planarian

Extreme Environmental Stress-Induced Biological Responses in the Planarian

Effects of large gradient high magnetic field (LG‐HMF) on the long‐term culture of aquatic organisms: Planarians example

The Effects of the Low Temperature Argon Plasma on Stem Cells Proliferation and Regeneration in Planarians

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