Intermittent esotropia as the initial presentation of juvenile nasopharyngeal angiofibroma

Salcone, Erin M.; Pepin, Susan M.

doi:10.1016/j.jaapos.2003.12.003

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…Smaller lesions, particularly if they are adjacent to an extraocular muscle, may initially present with strabismus. 12 …”

Section: Orbital Massesmentioning

confidence: 99%

Orbital causes of incomitant strabismus

Lueder¹

2015

Middle East Afr J Ophthalmol

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Strabismus may result from abnormal innervation, structure, or function of the extraocular muscles. Abnormalities of the orbital bones or masses within the orbit may also cause strabismus due to indirect effects on the extraocular muscles. This paper reviews some disorders of the orbit that are associated with strabismus, including craniofacial malformations, orbital masses, trauma, and anomalous orbital structures.

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“…Smaller lesions, particularly if they are adjacent to an extraocular muscle, may initially present with strabismus. 12 …”

Section: Orbital Massesmentioning

confidence: 99%

Orbital causes of incomitant strabismus

Lueder¹

2015

Middle East Afr J Ophthalmol

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“…Finally, 33 articles with 41 cases describing 44 lesions met the selection criteria for the systematic review (Figure 1). 10,26–57 With 13 additional cases from our institution (Table 1), the final study cohort comprised 54 cases with 57 lesions associated with STAs.…”

Section: Resultsmentioning

confidence: 99%

MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review

Baba

Kurokawa

et al. 2023

Journal of Neuroimaging

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Background and PurposeTo comprehensively summarize the radiological characteristics of sinonasal tract angiofibroma (STA) (commonly known as juvenile nasopharyngeal angiofibroma).MethodsForty‐four lesions from 41 cases provided by 33 study articles identified through a systematic review and 13 lesions from 13 cases from our institution associated with patients with STA who underwent MRI were included in the review study, carried out by two board‐certified experienced radiologists.ResultsThe study participants were all male patients with a mean age of 15.6 years at the time of diagnosis. All of them presented with nasal cavity lesions (100%), predominantly in the nasopharynx (98.2%). The sphenopalatine foramen/pterygopalatine fossa was involved in 76.0%, and compressive shift of the posterolateral wall of the maxillary sinus was present in more than half (57.9%). T2‐weighted imaging signal intensity was heterogeneous with mixed high and iso intensities as compared to skeletal muscle (100%). T1‐weighted imaging showed partial high signal intensity in 61.1% of the cases. Flow void and intense enhancement were present in almost all cases. Cystic/nonenhancement changes on contrast‐enhanced MRI were relatively common (40.8%). The mean apparent diffusion coefficient value (2.07 × 10−3 mm2/second) and some quantitative dynamic contrast‐enhanced MRI parameters were high. There was a significant difference in the frequency of residual/recurrent lesions based on the presence of MRI findings of skull base invasion (p = .017) and intracranial extension (p = .003).ConclusionsWe summarized the MRI findings of STA that can facilitate timely diagnosis and appropriate management.

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“…of patients No. of Patients < 10 years Age (years) Sex Follow-up Gaillard [ 40 ] R 16 1 9 M 7 yrs Kalani [ 8 ] R 22 1 9 M 1 mo Ardehali [ 5 ] R 47 1 7 M 2.5 yrs Ferreira [ 39 ] P 9 1 9 M 1 yr Handa [ 22 ] C 1 1 8 M 6 mo Baptista [ 38 ] C 1 1 8 F 6 mo Salcone [ 37 ] C 1 1 9 M 6 mo Gupta [ 23 ] CS 8 2 1: 4 2: 6 …”

Section: Resultsmentioning

confidence: 99%

Early-Onset Juvenile Nasopharyngeal Angiofibroma (JNA): A Systematic Review

Newman,

Nguyen,

McHugh

et al. 2023

Journal of Otolaryngology - Head & Neck Surgery

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Background Juvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1–6]. Significant androgen stimulation is hypothesized to explain the strong predisposition for JNA to present in young adolescent males. However, considerable variability in age at diagnosis exists with rare involvement of very young patients incongruent with typical male pubertal growth patterns. Objective The purpose of this systematic review is to identify cases of early-onset JNA (EOJNA), (defined as age < 10 years) in the literature and to examine the disease characteristics and treatments used in this patient group. A case of a 7 year old boy with EOJNA at our institution is also described and presented. Methods We searched Embase, Cochrane database and MEDLINE from 1996 to February 2021 for studies that reported cases of EOJNA. Relevant clinico-demographic data, disease severity and treatment outcomes were recorded and analyzed using descriptive statistics. We compared our findings with reported means for JNA in all ages. Results We identified 29 studies containing a total of 34 cases of EOJNA. The vast majority (31/34) of patients were males and the mean age of diagnosis was 8.15 years old. The most common presenting symptoms were nasal obstruction (65.2%) and epistaxis (60.9%). Patients were most commonly Radkowski stage II (39.4%) and III (39.4%). Primary treatment modalities included open surgery (66.7%), endoscopic surgery (24.2%), and radiotherapy (9.1%). Recurrence was evident in 30%. Radkowski stage and type of treatment did not differ significantly within the EOJNA group (p = 0.440 and p = 0.659, respectively). Conclusion This systematic review suggests that rare cases of EOJNA have distinct disease characteristics. Patients in this cohort appeared to have more advanced disease and higher recurrence rates when compared with reported averages. We hope that this review prompts increased clinical awareness of this potentially more aggressive subtype of JNA. As more cases of EOJNA are reported, a more powered statistical analysis of this cohort would be feasible.

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Intermittent esotropia as the initial presentation of juvenile nasopharyngeal angiofibroma

Cited by 5 publications

References 5 publications

Orbital causes of incomitant strabismus

Orbital causes of incomitant strabismus

MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review

Early-Onset Juvenile Nasopharyngeal Angiofibroma (JNA): A Systematic Review

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