Intermittent blurred vision and trichomegaly due to latanoprost

Woo, Thomas; Francis, Ian C.

doi:10.1046/j.1442-9071.2001.00416.x

Cited by 17 publications

(15 citation statements)

References 6 publications

(9 reference statements)

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“…“Secondary” or acquired trichomegaly has also been observed in systemic diseases with immune system involvement, such as systemic lupus erythematosus (SLE) (19), dermatomyositis (20), and human immunodeficiency virus (HIV) infection (21–24), and during treatment with interferon (IFN)‐α (6–8), cyclosporine (9,10), and latanoprost (11–18). However, none of our patients had any of these diseases, and none were treated with these drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Indirect evidence of the possible effect of prostaglandins secreted by conjunctival mast cells on eyelash growth comes from the results of clinical trials of latanoprost, a prostaglandin F 2α analogue used as a topical treatment for glaucoma (16). This drug has been reported to induce growth of eyelashes and ancillary hairs around the eyelids (11–14,17,18). Specific manifestations include greater length and thickness of the lashes and additional rows of lashes (17).…”

Section: Discussionmentioning

confidence: 99%

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Eyelash Length in Children and Adolescents with Allergic Diseases

Levy

Segal

Ben‐Amitai

et al. 2004

Pediatric Dermatology

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Long eyelashes may be congenital, acquired in association with certain systemic diseases, or drug induced. In the past, long eyelashes were considered an external sign found in children with allergic diseases. However, this claim has never been examined in a controlled study. We compared the eyelash lengths of allergic children and adolescents with perennial allergic rhinitis, with or without bronchial asthma and atopic dermatitis (n = 60) to those of age- and sex-matched nonallergic controls (n = 80). The eyelashes of the allergic patients were found to be significantly longer than those of the controls: 9.43 +/- 1.39 mm versus 8.45 +/- 1.30 mm (p < 0.001). Eyelash length did not differ between patients with allergic rhinitis only (n = 31; 9.65 +/- 1.43 mm) and patients with allergic rhinitis and other allergic diseases (n = 29; 9.19 +/- 1.31 mm) (p = 0.196). These results indicate that children and adolescents with allergic diseases have longer eyelashes compared to nonatopic controls and that long eyelashes may be a part of the phenotype of the allergic patient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Eyelash Length in Children and Adolescents with Allergic Diseases

Levy

Segal

Ben‐Amitai

et al. 2004

Pediatric Dermatology

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“…Another study observed 317 patients treated with topical latanoprost once daily and found that 77% of patients developed eyelash trichomegaly 73 . More recently, Woo and Francis 8 reported eyelash trichomegaly in three patients following unilateral latanoprost therapy. Three to six months into treatment, they documented the difference in eyelash length of the treated eye compared with the untreated eye; they noted increased number, density, and thickness of the eyelashes in the latanoprost‐treated eye.…”

Section: Prostaglandinsmentioning

confidence: 99%

“…The presence of eyelash trichomegaly may be congenital or familial, associated with an acquired condition, or drug induced. The occurrence of eyelash trichomegaly can be psychologically disturbing and may lead to visual disturbances, mechanical ptosis and, if trichiasis occurs, corneal abrasions 4,7–9 . The pathophysiology of eyelash growth shall briefly be summarized; also, congenital conditions, acquired conditions, and drugs associated with eyelash trichomegaly shall be reviewed.…”

Section: Introductionmentioning

confidence: 99%

Eyelash trichomegaly: review of congenital, acquired, and drug‐associated etiologies for elongation of the eyelashes

Paul¹,

Cohen

Kurzrock

2012

Int J Dermatology

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Eyelash trichomegaly is defined as eyelashes which are found to be of increased length, thickness, and pigmentation. This unique finding can be present at birth as part of a variety of congenital syndromes or as a benign familial trait. There are also acquired conditions and drugs that are known to cause these changes. Case reports and clinical studies in the medical literature concerning eyelash trichomegaly were investigated and summarized to compile a comprehensive review of the etiology of eyelash trichomegaly. Previously published reviews and studies that report on the finding of increased generalized hair growth and which do not specifically mention eyelashes were not included. Trichomegaly of the eyelashes may occur as a key feature among rare congenital syndromes, develop in association with certain acquired diseases, or present as an intended or treatment-related adverse drug effect. Eyelash trichomegaly may be present from birth or manifest later in life in association with acquired diseases or drug therapy. The relevance of this finding may be benign, however eyelash trichomegaly in some individuals can be a symptom for immune dysfunction or a clinical measure of response to drug therapy.

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“…The treatment is symptomatic and sometimes requires the use of artificial tears to prevent associated meibomitis. [3]…”

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confidence: 99%