Intermittent azoospermia associated with epididymal sarcoidosis

Svetec, David A.; Waguespack, Robert L.; Sabanegh, Edmund

doi:10.1016/s0015-0282(98)00272-6

Cited by 36 publications

(32 citation statements)

References 5 publications

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“…Another problem that epididymal sarcoidosis may be associated with is azoospermia, continuous or intermittent. [80] The primary treatment is with corticosteroids. [81] Several alternative therapies can be found in Ghazie and Bhatt.…”

Section: Scrotum Testicular and Paratesticular Structuresmentioning

confidence: 99%

Genitourinary sarcoidosis: An essential review for the practicing clinician

Block

Kava

2017

Indian J Urol

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Introduction:Sarcoidosis is a multisystem disease that commonly involves the lungs, but may also present with extrapulmonary manifestations. Genitourinary (GU) tract involvement has been traditionally thought to be rare, but that view may underestimate the true prevalence of the disease due to the often, silent presentation thereof.Methods:The literature pertaining to sarcoidosis from the general systemic point of view, etiology and therapy and with regard to specific organs was reviewed by identifying key words in a PubMed search. That material with special relevance to the Indian experience was emphasized.Results:There are a number of isolated case reports in the literature describing symptomatic and asymptomatic GU tract sarcoidosis. The world literature associated with the generalized syndrome was reviewed and summarized. Specific aspects of GU involvement are presented for each organ of the GU tract.Conclusions:It is critical for the practicing clinician to have a working knowledge of the clinical manifestations of this disease as it involves the GU tract, as well as to be able to distinguish it from tuberculosis and the various malignancies that affect this organ system.

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Section: Scrotum Testicular and Paratesticular Structuresmentioning

confidence: 99%

Genitourinary sarcoidosis: An essential review for the practicing clinician

Block

Kava

2017

Indian J Urol

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“…Genitourinary involvement by sarcoidosis is very rare, accounting for 0.2% of cases. However, infertility due to epididymal sarcoidosis is usually reversible and shows good result following anti-inflammatory therapy [12, 13]. On the other hand, genitourinary tuberculosis is relatively more common and accounts for 20–73% of all cases of extra-pulmonary tuberculosis in the general population [14].…”

Section: Discussionmentioning

confidence: 99%

Optic disc granuloma with epididymitis: a diagnostic challenge

Majumder¹,

Ali²,

Biswas³

2017

J Ophthal Inflamm Infect

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BackgroundSarcoidosis and tuberculosis (TB) share epidemiological, immunological, and molecular features common to both, and often, it becomes difficult to differentiate them especially in a highly TB-endemic country like India. We report a case of optic disc granuloma along with epididymitis and infertility in a male who showed a response to treatment with anti-tuberculosis therapy and steroids.ResultsA 35-year-old Indian male who presented with complaints of blurring vision in the right eye for 6 months and treated elsewhere with two intravitreal injections of anti-VEGF was found to have optic disc granuloma in the right eye. His investigations revealed highly positive Mantoux test, negative QuantiFERON test, elevated serum ACE, and HRCT of chest showing features of sarcoidosis. He also gave a history of primary infertility. Ultrasound Doppler of the scrotum was suggestive of epididymitis. After getting a chest physician opinion, the patient was started on the first line of ATT followed by oral steroids. On subsequent follow-up visits, the patient showed resolution of lesions along with the return of fertility.ConclusionsThe index case of optic disc granuloma along with epididymitis had features of both tuberculosis and sarcoidosis and falls in the gray zone of tuberculous sarcoidosis and showed a response to both ATT and corticosteroids. We report this case report for its unique presentation.

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“…Extrapulmonary involvements such as cardiovascular system, nervous system, upper respiratory tract, kidneys, spleen, thyroid, gastrointestinal tract, and musculoskeletal involvement is rare (0.4 to 5%) (3,6). Genitourinary tract involvement is much more uncommon (0.2%), and usually gives no symptom with a clinically silent presentation (7,8). Clinical course and prognosis of the disease are influenced by ethnic and genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Penile Sarcoidosis: A Rare Initial Manifestation

Doruk¹,

Uçan²,

Doğan³

et al. 2016

Respir Case Rep

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Sarcoidosis is a multi-systemic disease and genitourinary involvement is rarely seen. Penile involvement is even rarer among genitourinary sarcoidosis. In this article, we present two cases of penile sarcoidosis. The first case was admitted to our urology clinic with penile itching and pain and his symptoms did not improve with non-specific antibiotic therapy. In biopsy, non-caseified granulomatous inflammation was detected. He did not have any systemic and pulmonary compliant. The second case was admitted to our urology clinic with penile nodules and nodules were excised for diagnosis. In dermis biopsy, multiple multi-nuclear giant cells and granulomas were detected. He had shortness of breath, wheezing, and sweating. He was treated with systemic prednisolone. Both cases were successfully treated with pharmacological treatments.

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Intermittent azoospermia associated with epididymal sarcoidosis

Cited by 36 publications

References 5 publications

Genitourinary sarcoidosis: An essential review for the practicing clinician

Genitourinary sarcoidosis: An essential review for the practicing clinician

Optic disc granuloma with epididymitis: a diagnostic challenge

Penile Sarcoidosis: A Rare Initial Manifestation

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