Intermittent Alveolar Overdistension for 30 or 240 Minutes Does Not Produce Acute Lung Injury in Normal Pig Lung

Extravascular lung water after pneumonectomy and one-lung ventilation in sheep

“…On the other hand, the increase in airway pressures subsequent to a doubling of the V T to the injuriously ventilated lung was not surprising. However, our findings agree with those of Garcia-Delgado et al (24), who showed that pulmonary edema did not develop during a period of Ն4 hrs in large animals subjected to mechanical ventilation with V T as high as 50 mL/kg. In our own pilot experiments on anesthetized sheep (unpublished data), almost all the animals developed barotrauma (e.g., pneumothorax or pneumomediastinum) after 8 -12 hrs of ventilation with V T of 30 -50 mL/kg, without being preceded by pulmonary edema or derangements of gas exchange.…”

The effects of methylene blue on ovine post‐pneumonectomy pulmonary oedema

“…According to other investigators and our own unpublished observations, ventilation with high tidal volumes can be tolerated by larger animals for hours without any noticeable lung injury 17,18 . In the present study, lung injury could be expected to occur after PE, particularly because the normal tidal volume of both lungs combined had been doubled, and taken over by the remaining lung.…”

Brief, Large Tidal Volume Ventilation Initiates Lung Injury and a Systemic Response in Fetal Sheep

“…A doubling of the normal VT would cause minimal injury in the healthy adult lung or in a postnatal rodent with incomplete alveolarization (35). A VT as large as 50 ml/kg for 4 hours did not cause lung injury in healthy pigs (37).…”