2014
DOI: 10.3389/fncel.2014.00376
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Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits

Abstract: cAMP critically modulates the development of neuronal connectivity. It is involved in a wide range of cellular processes that require independent regulation. However, our understanding of how this single second messenger achieves specific modulation of the signaling pathways involved remains incomplete. The subcellular compartmentalization and temporal regulation of cAMP signals have recently been identified as important coding strategies leading to specificity. Dynamic interactions of this cyclic nucleotide w… Show more

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Cited by 52 publications
(61 citation statements)
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References 101 publications
(147 reference statements)
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“…cAMP has been suggested to serve as an important mediator in axonal growth (Averaimo and Nicol, 2014). By using photo-activated adenylyl cyclase (PAC) to locally increment cAMP levels, a recent study revealed that short term elevation of intracellular cAMP induces axonal branching via Protein Kinase A (PKA) activation (Zhou et al 2016).…”
Section: Signaling Mechanisms That Regulate Cytoskeletal Dynamics Durmentioning
confidence: 99%
“…cAMP has been suggested to serve as an important mediator in axonal growth (Averaimo and Nicol, 2014). By using photo-activated adenylyl cyclase (PAC) to locally increment cAMP levels, a recent study revealed that short term elevation of intracellular cAMP induces axonal branching via Protein Kinase A (PKA) activation (Zhou et al 2016).…”
Section: Signaling Mechanisms That Regulate Cytoskeletal Dynamics Durmentioning
confidence: 99%
“…Crosstalk between second messengers, cyclic nucleotides and Ca 2+ , plays a crucial role in axon pathfinding (Nicol et al, 2011; Averaimo and Nicol, 2014) and modulates the axonal response to Netrin-1 (Hong et al, 2000). We investigated the effects of somatic, axonal, and global Netrin-1 treatments on cyclic nucleotides activity in growth cones and cell bodies with genetically encoded FRET reporters: cGMP reporter cGi500 (Russwurm et al, 2007) or cAMP reporter epac2-camp (Nikolaev et al, 2004).…”
Section: Resultsmentioning
confidence: 99%
“…Thus, cAMP and cGMP appear to exert opposing influences on neurite aligment to microtopographical features similar to their opposing effects on chemotactive biochemical cues. 63,64 Interestingly, SGSC alignment to the micropatterns, which, like to SGN neurite alignment, depends on RhoA/ ROCK signaling, 21 was likewise disrupted by ryanodine and IP3 receptor inhbitors and by treatment with a cAMP analog. Further, treatment with a cGMP analog enhanced SGSC alignment to micropatterns.…”
Section: Discussionmentioning
confidence: 99%