Intermediate Syndrome and Marchiafava-Bignami Syndrome: Double Trouble in Weaning Off

Abstract

Intermediate syndrome affects 10-40% of those with severe organophosphorus poisoning, causing delayed weakness in the proximal parts of the body, neck flexors, and breathing muscles. We present the case of organophosphorus poisoning that advanced to intermediate syndrome and subsequently worsened, with imaging later revealing the Marchiafava-Bignami condition, which aggravated the intermediate syndrome.

Comparative analysis of organophosphorus versus carbamate pesticide poisoning: a case study

“…Furthermore, in addition to cholinergic crisis and shock symptoms, 10–40 % of patients with organophosphorus poisoning may develop the intermediate syndrome (IMS) within 24–96 h of the initial improvement of poisoning symptoms. The IMS is characterised by muscle paralysis primarily affecting proximal, craniofacial, and respiratory muscles and may, in severe cases, end with respiratory arrest ( 20 , 21 ). However, the incidence of IMS in patients with carbamate poisoning is lower than that of organophosphorus poisoning ( 22 ).…”

Exploring Marchiafava-Bignami Disease: A Rare Presentation in a Young Pregnant Female

“…The patients appeared in a coma and with convulsions after consuming an excessive amount of inexpensive red wine [4][5][6].…”

Acute Ischemic Stroke Post Honeybee Sting: A Rare Case Report

“…Various conditions are rare and associated with acute ischemic strokes like organophosphorus poisoning leading to the intermediate syndrome, suicidal method of hanging, or infection such as COVID-19 [7][8][9].…”