Intermediate Clinical and Hemodynamic Outcomes After Transcatheter Aortic Valve Implantation

D’Onofrio, Augusto; Facchin, Michela; Besola, Laura; Manzan, Erica; Tessari, Chiara; Bizzotto, Eleonora; Bianco, Roberto; Tarantini, Giuseppe; Napodano, Massimo; Fraccaro, Chiara; Buja, Paolo; Covolo, Elisa; Yzeiraj, Ermela; Pittarello, Demetrio; Isabella, Giambattista; Iliceto, Sabino; Gerosa, Gino

doi:10.1016/j.athoracsur.2015.08.032

Cited by 17 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The median number of patients per study was 120 (interquartile range 60-292) with median followup of 5 years (interquartile range 5-6 years, mean follow-up 5.6 years). These studies included 23 single-center studies (6,10,) and 8 multi-center studies (39)(40)(41)(42)(43)(44)(45)(46), where 14 were retrospective and 15 had prospective enrolment. The studies were conducted in the UK, Italy, Germany, US, Canada, Spain, Israel, Denmark and Sweden.…”

Section: Resultsmentioning

confidence: 99%

“…Earlier studies also studied TAVI beyond the context of calcific AS, in pure aortic regurgitation patients (65,66), bicuspid aortic valve and (as in a number of our included studies) valve-in-valve for both redo-TAVI or SAVR (6,25,32,67,68).…”

Section: Tavi Trials Expanding Indications and Criticismsmentioning

confidence: 99%

“…These early successes led to a number of trials, such as the PARTNER and US Pivotal trials, which compared TAVI, SAVR and standard treatment outcomes ( Figure 1). As a result, TAVI is increasingly being considered as a less-invasive option for treatment of AS in younger and lower surgical risk patients, where SAVR is not necessarily contraindicated (6,7), although this is not without controversy (8).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long term outcomes of transcatheter aortic valve implantation (TAVI): a systematic review of 5-year survival and beyond

Chakos

Wilson-Smith

Arora

et al. 2017

Ann. Cardiothorac. Surg.

Self Cite

View full text Add to dashboard Cite

Background: Transcatheter aortic valve implantation/replacement (TAVI/TAVR) is becoming more frequently used to treat aortic stenosis (AS), with increasing push for the procedure in lower risk patients.Numerous randomized controlled trials have demonstrated that TAVI offers a suitable alternative to the current gold standard of surgical aortic valve replacement (SAVR) in terms of short-term outcomes. The present review evaluates long-term outcomes following TAVI procedures.Methods: Literature search using three electronic databases was performed up to June 2017. Studies which included 20 or more patients undergoing TAVI procedures, either as a stand-alone or concomitant procedure and with a follow-up of at least 5 years, were included in the present review. Literature search and data extraction were performed by two independent researchers. Digitized survival data were extracted from Kaplan-Meier curves in order to re-create the original patient data using an iterative algorithm and subsequently aggregated for analysis.Results: Thirty-one studies were included in the present analysis, with a total of 13,857 patients. Two studies were national registries, eight were multi-institutional collaborations and the remainder were institutional series. Overall, 45.7% of patients were male, with mean age of 81.5±7.0 years. Where reported, the mean Logistic EuroSCORE (LES) was 22.1±13.7 and the mean Society of Thoracic Surgeons (STS) score was 9.2±6.6. The pooled analysis found 30-day mortality, cerebrovascular accidents, acute kidney injury (AKI) and requirement for permanent pacemaker (PPM) implantation to be 8.4%, 2.8%, 14.4%, and 13.4%, respectively. Aggregated survival at 1-, 2-, 3-, 5-and 7-year were 83%, 75%, 65%, 48% and 28%, respectively. Conclusions:The present systematic review identified acceptable long-term survival results for TAVI procedures in an elderly population. Extended follow-up is required to assess long-term outcomes following TAVI, particularly before its application is extended into wider population groups. Ann Cardiothorac Surg 2017;6(5):432-443 www.annalscts.com IntroductionAs Western populations age, the prevalence of aortic stenosis (AS) is gradually increasing (1). In a select population, surgical aortic valve replacement (SAVR) is precluded by patient frailty and other comorbidities (2). The availability of transcatheter aortic valve implantation/ replacement (TAVI/TAVR), pioneered in the early 2000s, has made a significant impact on survival for these patients (3-5). These early successes led to a number of trials, such as the PARTNER and US Pivotal trials, which compared TAVI, SAVR and standard treatment outcomes ( Figure 1). As a result, TAVI is increasingly being considered as a less-invasive option for treatment of AS in younger and lower surgical risk patients, where SAVR is not necessarily contraindicated (6,7), although this is not without controversy (8).While the short-term outcomes of TAVI have been well explored, limited studies have examined longer term results (9,10). Additiona...

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Tavi Trials Expanding Indications and Criticismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long term outcomes of transcatheter aortic valve implantation (TAVI): a systematic review of 5-year survival and beyond

Chakos

Wilson-Smith

Arora

et al. 2017

Ann. Cardiothorac. Surg.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our initial literature search resulted in total of 3,447 articles. A total of 25 articles [3,[6][7][8][9][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] including total of 21,018 patients were finally included for quantitative synthesis (meta-analysis). Detailed study selection flow is summarized in Supporting Information 1.…”

Section: R Esu L Tsmentioning

confidence: 99%

Does mild paravalvular regurgitation post transcatheter aortic valve implantation affect survival? A meta‐analysis

Ando

Briasoulis

Telila

et al. 2017

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

“…There is growing evidence suggesting a significant association of postprocedural AR with short-and long-term mortality. 18,32,33 In a metaanalysis of 12 926 patients from 45 studies (a majority using Edwards SAPIEN devices), moderate or more AR was associated with a 2.3-fold increase in 1 year mortality following TAVR. 34 Our study used CMR to study the evolution of AR over time.…”

Section: Aortic Regurgitation Following Tavrmentioning

confidence: 99%

Cardiovascular magnetic resonance assessment of 1st generation CoreValve and 2nd generation Lotus valves

Musa

Uddin

Dobson

et al. 2018

J Interven Cardiology

View full text Add to dashboard Cite

show abstract

Intermediate Clinical and Hemodynamic Outcomes After Transcatheter Aortic Valve Implantation

Abstract: Our data show that TAVI has good early and intermediate-term clinical and hemodynamic outcomes in high-risk or inoperable patients with severe symptomatic aortic valve stenosis. PVL of any grade has a significant impact on survival.

Cited by 17 publications

References 26 publications

Long term outcomes of transcatheter aortic valve implantation (TAVI): a systematic review of 5-year survival and beyond

Long term outcomes of transcatheter aortic valve implantation (TAVI): a systematic review of 5-year survival and beyond

Does mild paravalvular regurgitation post transcatheter aortic valve implantation affect survival? A meta‐analysis

Cardiovascular magnetic resonance assessment of 1st generation CoreValve and 2nd generation Lotus valves

Contact Info

Product

Resources

About