Interlinking antidepressants and the immune system

Lisowska, Katarzyna A.; Pietruczuk, Krzysztof; Szałach, Łukasz P.

doi:10.1016/b978-0-12-817933-8.00050-5

Cited by 1 publication

(1 citation statement)

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“…In bivalves, BCAAs have already been suggested to serve as biomarkers of immune stress after exposure to V. harveyi [ 38 ]. In humans, SNRIs and serotonin selective reuptake inhibitors (SSRI) were demonstrated to modify the activities of lymphocytes and monocytes and to have anti-inflammatory and immunosuppressive effects [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach

et al. 2022

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There is growing evidence of the presence of pharmaceuticals in natural waters and their accumulation in aquatic organisms. While their mode of action on non-target organisms is still not clearly understood, their effects warrant assessment. The present study assessed the metabolome of the Mediterranean mussel (Mytilus galloprovincialis) exposed to a 10 µg/L nominal concentration of the antidepressant venlafaxine (VLF) at 3 time-points (1, 3, and 7 days). Over the exposure period, we observed up- or down-modulations of 113 metabolites, belonging to several metabolisms, e.g., amino acids (phenylalanine, tyrosine, tryptophan, etc.), purine and pyrimidine metabolisms (adenosine, cyclic AMP, thymidine, etc.), and several other metabolites involved in diverse functions. Serotonin showed the same time-course modulation pattern in both male and female mussels, which was consistent with its mode of action in humans, i.e., after a slight decrease on the first day of exposure, its levels increased at day 7 in exposed mussels. We found that the modulation pattern of impacted metabolites was not constant over time and it was gender-specific, as male and female mussels responded differently to VLF exposure.

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Section: Discussionmentioning

confidence: 99%