Interleukins-6, -8 and -12p40 and C-reactive protein levels
in patients with acne vulgaris with various severityof skin
changes

Stańkowska, Anna; Bergler‐Czop, Beata; Brzeźińska-Wcisło, Ligia

doi:10.5114/dr.2020.99876

Cited by 2 publications

(2 citation statements)

References 24 publications

(54 reference statements)

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“…Over-accumulation of Hcy can block the metabolic level of prostacyclin in the body, so that the LDL level continues to increase, which will affect the function of the vascular wall, causing damage to the wall of the tube, accelerating the rate of thrombosis, intensifying the blood clotting response, and finally, patients will be prone to atherosclerotic lesions. After consulting domestic research materials, it was found that a high Hcy level will increase the cerebrovascular endothelial damage and prethrombotic status in patients with AD, and other materials also indicate that a high Hcy level in the body will inhibit the activity of lysyl oxidase itself in the vascular endothelial cells, generating superoxide anions and derivative substances such as nitric oxide nitrite in the body, so that the body will be accompanied by damage to the nitric oxide pathway, and may have an excessive oxidative stress response [ 15 ]. CRP is a special protein synthesized and secreted by liver tissues, which is widely used in the evaluation of inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Changes in Levels of Homocysteine and C-Reactive Protein in Patients with Alzheimer's Disease and Their Correlation with Cognitive and UPDRS Functions

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the changes in the levels of homocysteine (Hcy) and C-reactive protein (CRP) in patients with Alzheimer's disease (AD) and analyze their correlation with cognitive and UPDRS functions. Methods. A total of 50 patients with AD admitted to our hospital from January 2020 to March 2022 were selected into the research group, and 50 healthy subjects were selected as the control group. The levels of Hcy and CRP of the two groups were analyzed, and the patients’ cognitive functions were evaluated with the Mini-Mental State Examination (MMSE) score and UPDRS function scoring. The correlation between the changes in levels of Hcy and CRP, and cognitive and UPDRS functions in the two groups was compared and analyzed. Results. The levels of Hcy and CRP of the research group were higher than those of the control group, with statistical significance ( P < 0.05 ). The following were evaluated for the scoring of patients’ cognitive functions in the research group: orientation, attentional computation, short-term memory, language ability, visuospatial ability, instant memory, and MMSE total score, all of which were lower than those in the control group, with statistical significance ( P < 0.05 ). UPDRS I, UPDRS, UPDRS, and total UPDRS score in the research group were higher than those in the control group, with statistical significance ( P < 0.05 ). In the research group, the higher the Hcy level, the lower the MMSE score, with a negative correlation ( P < 0.05 ), and the higher the Hcy level, the higher the UPDRS score, with a positive correlation ( P < 0.05 ). And, the higher the CRP level, the lower the MMSE score, with a negative correlation ( P < 0.05 ); the higher the CRP level, the higher the UPDRS score, with a positive correlation ( P < 0.05 ). Conclusion. Compared with the health subject group, the levels of Hcy and CRP were higher in patients with AD, and their changes had a negative correlation with cognitive functions in patients with AD, and a positive correlation with UPDRS in patients with AD, with high clinical values in evaluating cognitive and UPDRS functions.

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Section: Discussionmentioning

confidence: 99%

Changes in Levels of Homocysteine and C-Reactive Protein in Patients with Alzheimer's Disease and Their Correlation with Cognitive and UPDRS Functions

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…evaluated serum IL-6 and IL-8 levels in acne patients and controls. [ 17 ] They reported raised IL-6 level, but IL-8 level showed no differences among the groups. They started as the severity of disease progresses and IL-6 levels increase.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Levels of Interleukins 6, 8, 17 and 22 in Acne Vulgaris

Singh

Khurana

Chitkara

2023

Indian Journal of Dermatology

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Background: Acne vulgaris (AV) is a chronic, multifactorial, inflammatory skin disease, and it is now becoming increasingly clear that the inflammatory pathway is involved at a very early in the pathogenesis of acne. The Th17 cells, the activators of this cell line and its downstream effector cytokines, are all likely to have a critical role in inducing and maintaining the disease. Aim: To analyse the role of interleukins (ILs) 6, 8, 17 and 22 in the pathogenesis of acne. Materials and Methods: Sixty patients of AV and thirty age- and sex-matched controls were included in our study. Serum levels of interleukins 6, 8, 17 and 22 were determined using an enzyme-linked immunosorbent assay (ELISA), and thereafter, levels were correlated with the severity of acne. Result: Serum levels of IL-6, IL-8, IL-17 and IL-22 were 0.15 ± 0.0174 pg/ml, 0.38 ± 0.080 pg/ml, 0.19 ± 0.0075 pg/ml and 0.23 ± 0.0152 pg/ml in cases, respectively, and 0.13 ± 0.0095 pg/ml, 0.14 ± 0.034 pg/ml, 0.13 ± 0.0033 pg/ml and 0.21 ± 0.0099 pg/ml in controls, respectively. The difference in levels between cases and controls was significant for IL-8 and IL-17, while for IL-6 and IL-22 the difference was insignificant. There was a highly significant positive correlation between IL-8 and IL-17 levels. IL-6 and IL-8 showed a significant positive correlation with the severity of disease. Conclusion: IL-8 and IL-17 play a critical effector role in the pathogenesis of AV. IL-6-stimulated Th17 cells are likely the major producers of IL-8 in acne lesions.

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Interleukins-6, -8 and -12p40 and C-reactive protein levels in patients with acne vulgaris with various severityof skin changes

Cited by 2 publications

References 24 publications

Changes in Levels of Homocysteine and C-Reactive Protein in Patients with Alzheimer's Disease and Their Correlation with Cognitive and UPDRS Functions

Changes in Levels of Homocysteine and C-Reactive Protein in Patients with Alzheimer's Disease and Their Correlation with Cognitive and UPDRS Functions

Evaluation of Serum Levels of Interleukins 6, 8, 17 and 22 in Acne Vulgaris

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