Interleukine 6 and C-reactive protein predict growth impairment and acute malnutrition in children and adolescents with chronic kidney disease

Hernández, Karen; Haro, Alfredo Larrosa; Hita, Mercedes Elvira González; López, Fabiola Martín del Campo; Palencia, Clío Chávez; Cortez, Gustavo Pérez; Pamplona, Jacob Sandoval; Leon, E.

doi:10.20960/nh.02640

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…In children suffering from CKD, the development of anaemia was inversely correlated with IL-6 concentration [ 101 ]. Additionally, IL-6 predicted acute malnutrition and growth impairment among children and adolescents with CKD [ 102 ]. Certain studies revealed a possible link between IL-6 and pruritus occurrence due to chronic sulphur mustard exposure [ 103 ] and in the course of prurigo nodularis (PN) [ 104 ].…”

Section: Pathogenesis Of Ckd-aimentioning

confidence: 99%

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

Reszke

Kiliś‐Pstrusińska

Szepietowski

2021

Toxins

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Chronic kidney disease (CKD) is a condition of widespread epidemiology and serious consequences affecting all organs of the organism and associated with significant mortality. The knowledge on CKD is rapidly evolving, especially concerning adults. Recently, more data is also appearing regarding CKD in children. Chronic itch (CI) is a common symptom appearing due to various underlying dermatological and systemic conditions. CI may also appear in association with CKD and is termed chronic kidney disease-associated itch (CKD-aI). CKD-aI is relatively well-described in the literature concerning adults, yet it also affects children. Unfortunately, the data on paediatric CKD-aI is particularly scarce. This narrative review aims to describe various aspects of CKD-aI with an emphasis on children, based on the available data in this population and the data extrapolated from adults. Its pathogenesis is described in details, focusing on the growing role of uraemic toxins (UTs), as well as immune dysfunction, altered opioid transmission, infectious agents, xerosis, neuropathy and dialysis-associated aspects. Moreover, epidemiological and clinical aspects are reviewed based on the few data on CKD-aI in children, whereas treatment recommendations are proposed as well, based on the literature on CKD-aI in adults and own experience in managing CI in children.

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Section: Pathogenesis Of Ckd-aimentioning

confidence: 99%

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

Reszke

Kiliś‐Pstrusińska

Szepietowski

2021

Toxins

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Nutritional profile and infection-related hospital admissions in children with chronic kidney disease

Sravani,

Selvam,

Iyengar

2024

Pediatr Nephrol

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Nutritional profile and infection-related hospital admissions in children with chronic kidney disease

Madhileti,

Selvam,

Iyengar

2024

Preprint

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Protein energy wasting (PEW) and undernutrition are highly prevalent in children with chronic kidney disease (CKD), but their impact on clinical outcomes is not well-described. This prospective longitudinal study in children with CKD assessed the association of nutritional parameters with infection-related hospital admissions (IRHA). Methods: Children with CKD2-5D aged 2-18years, infection-free for 1 month were recruited over 5 years. Evaluation for undernutrition by subjective global nutritional assessment and for PEW using pediatric criteria were undertaken and categorised as mild (>2criteria), standard (>3criteria) and modified PEW (>3criteria with short stature). The IRHA (severe viral, bacterial or fungal infections) were recorded. Results: Among 137 children (45 on dialysis; age 123±46 months; 70% males) undernutrition was seen in 60% and PEW in 52%. Over 38±21 months follow-up, 107(78%) required hospital admissions (67% IRHA). The incidence rate of IRHA in days per patient-year was higher in those with undernutrition compared to well-nourished children [1.74(1.27,2.31) vs 0.65(0.44,0.92) p<0.0001] and higher in those with PEW compared to no PEW [1.74(1.30,2.28) vs 0.56(0.36,0.82) p<0.0001] respectively. On adjusted analysis, independent risk factors for IRHA were undernutrition, low BMI, hypoalbuminemia and dialysis status with modified PEW [OR5.34(2.16,13.1) p<0.001] and raised CRP [OR4.66(1.56,13.9) p=0.006] having the highest risk. Additionally, modified PEW and BMI were noted to have a 2-fold risk for recurrent infections. Conclusion: In children with CKD2-5D, incidence rate of IRHA was significantly high in those with undernutrition and PEW. While dialysis, poor nutritional status, inflammation were risk factors for IRHA, modified PEW and BMI were associated with recurrent infections.

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Interleukine 6 and C-reactive protein predict growth impairment and acute malnutrition in children and adolescents with chronic kidney disease

Cited by 3 publications

References 24 publications

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

Nutritional profile and infection-related hospital admissions in children with chronic kidney disease

Nutritional profile and infection-related hospital admissions in children with chronic kidney disease

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