Interleukin_4 gene polymorphisms and connect with asthma patients province of Thi-Qar /Iraq

Association between interleukin-4 C589T polymorphism and asthma in Iraq: Ameta-analysis

“…The initial screening excluded studies that failed to meet the inclusion criteria. After ltering by availability and reading, consisting of reading the title, abstract, and keywords of each study, ve articles were selected [10][11][12][13][14] . The study selection process was visually presented in Fig.…”

“…Quality assessments of the selected studies are shown in Table 2. According to the NOS, three studies [12][13][14] had a risk of bias due to differences between the number of cases and the number of case genotypes in hospital controls. However, they were still considered to be of moderate quality, scoring 5 or 6 points.…”

“…However, they were still considered to be of moderate quality, scoring 5 or 6 points. HWE was detected in the asthmatic patients and controls in all studies [10][11][12][13][14] . All studies suggested that the distribution of genotypes in the controls was consistent with HWE except one study [10] , as shown in Table 3.…”

“…Five studies [10][11][12][13][14] with available data can be included to estimate the pool effect sizes under allele (C vs. T), homozygous (CC vs. TT), heterozygous (CT vs. TT) and recessive (CC vs. CT + TT) models. For the dominant (CC + CT vs. TT) model, there were ve studies [10][11][12][13][14] with available data that can be included to estimate the pool effect sizes. Although all these ve genetic models have a higher risk of asthma, the overall analyses were not statistically signi cant (Table 4).…”

“…Hassan [12] 2022 Iraq Thi-Qar Mixed 60/30 RFLP-PCR Hussein and Jaber [13] 2017 Abood and Mohanad, [10] * * ** * * 6…”