Interleukin polymorphisms and protein levels associated with lung cancer susceptibility and phenotypes

Ding, Kaiyue; Yi, Minhan; Li, Linsen; Zhang, Yuan

doi:10.1080/1744666x.2021.1952072

Cited by 9 publications

(5 citation statements)

References 77 publications

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“…Similar to other respiratory disease, 184,185 our results support that inflammation is essential in OSA development. TNF-α is an important pro-inflammatory cytokine involved in airway inflammation.…”

Section: Discussionsupporting

confidence: 85%

Variants of candidate genes associated with the risk of obstructive sleep apnea

Tan

et al. 2021

Eur J Clin Investigation

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Background The researches on the associations between different candidate genes and obstructive sleep apnea (OSA) are inconsistent. Here, we performed a comprehensive qualitative and quantitative analysis to estimate the contribution of variants from candidate genes to the risk of OSA. Methods Qualitative analysis was conducted to find the relationships for all included genes. Then, quantitative analysis of both allele models and genotype models was applied to evaluate the risk variants for OSA. Furthermore, a similar analysis was performed in different ethnic groups. Results We included 152 publications containing 75 genes for qualitative analysis. Among them, we included 93 articles containing 28 variants from 16 genes for quantitative analysis. Through allele models, we found 10 risk variants for OSA (rs1801133 of MTHFR, ɛ4 of ApoE, −1438G/A of 5‐HT2A, −308G/A of TNF‐α, Pro1019Pro of LEPR, rs1130864 and rs2794521 of CRP, D/I of ACE, LPR and VNTR of 5‐HTT) with the ORs of 1.21–2.07 in global population. We found that the variant of ɛ2 of ApoE could uniquely decrease the risk of OSA in the East Asian subgroup, while the other 6 variants, including ɛ4 in ApoE, −308G/A in TNF‐α, Pro1019Pro in LEPR, D/I in ACE, LPR and VNTR in 5‐HTT, could increase the risk of OSA. As for the European subpopulation, we only found that −308G/A in TNF‐α could increase the risk for OSA. Conclusions Eleven variants from the candidate genes are associated with the risk of OSA, which also show ethnicity differences in East Asian and European subgroups.

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Section: Discussionsupporting

confidence: 85%

Variants of candidate genes associated with the risk of obstructive sleep apnea

Tan

et al. 2021

Eur J Clin Investigation

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“…(Schaaf et al, 2003) confirmed that IL-10 allele G homozygous patients had the highest risk for septic shock and the G allele, associated with high IL-10 release that influence the outcome of pneumococcal infection via induced immunosuppression and impaired bacterial clearance. (Ding et al, 2021)IL-10 rs1800896 could increase LC risk, also found higher serum expression of IL-10 in LC patients than healthy controls, as well as higher proportion of positive IL-6 staining of lung tumor tissue in advanced (IIIA-Ⅳ) LC than early (IA-IIB) LC. Sung et al, (2013) IL-10 expression has been associated with poor outcome in stage I lung cancer, whereas in late-stage lung cancer, the presence of IL-10-positive macrophages at the tumor margins can be an indicator of poor prognosis.…”

Section: Il-10 Serum Level In Patients According To Stage Of Diseasementioning

confidence: 73%

Impact of IL-10-1082A\G promoter gene polymorphism and production in lung cancer patients

Nomi¹,

Darweesh²

2022

ijhs

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Lung cancer a deadliest malignant disease , Cytokines play a critical role in regulating host immune response toward cancer and determining the overall fate of tumorigenesis. So this study aimed to investigate the impact gene variation of IL-10 promotor region on production of IL-10 cytokine and their effect on lung cancer outcome. The aim of this study is the detection of IL-10-1082A\G polymorphism and IL-10 serum level with it correlation to progression of disease. A Case-control study was performed to 150 Lung cancer patients patients 54 females and 96 males and matched with age and gender attending to Middle Euphrates Cancer Center in AL-Najaf province with group of 60 healthy individual as control. Blood sample was collected from all patients and control. IL-10 level were measured by enzyme-linked immunosorbent assay (ELISA). Single nucleotide polymorphism detected by ARMS-PCR technique. The result shown that IL-10-1082 G/A significantly (P<0.05) high frequencies of homozygous GG, and G allele carrier in lung cancer patients, in contrast homozygous AA and AG genotype and A allele appear at low frequency with patients. The data showed that genetic variants of the IL-10 affect the IL-10 production and associated with the progression of disease.

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“…A recent meta-analysis was designed to explore the impact of 11 different variants of IL-1β, IL-4, IL-6, IL-8, and IL-10 from 43 studies on lung cancer susceptibility. The study selected 12 case-controlled studies for the rs16944 SNP and indicated that its allelic and genotypic frequencies were significantly linked to lung cancer susceptibility (Ding et al, 2021). On the contrary, other studies by Li and Wang, Pérez-Ramírez et al, and Kiyohara et al (2013; showed that there was a nonsignificant difference in the rs16944 variant between lung cancer cases and controls.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study

Metwally,

Zahran,

Elsadda

et al. 2023

Scientific Journal for Damietta Faculty of Science

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Lung cancer is a serious health and life issue, with the highest rates of incidence and mortality in the world. It is now clear that inflammation is a key factor involved in all aspects of carcinogenesis, notably lung cancer development. Genetic changes, including polymorphisms in inflammatory genes, are supposed to play a significant role in increasing lung cancer risk. In this study, we aim to investigate the association of IL-6 rs1800795 and IL-1β rs16944 polymorphisms with non-small cell lung cancer (NSCLC) development in the Egyptian population. The study design was composed of 100 NSCLC cases and 100 controls, which were genotyped using the ARMS-PCR technique, electrophoresed on a 2.5% agarose gel, and visualized using ethidium bromide under ultraviolet illumination. The IL-1β rs16944 genotypes were significantly different in NSCLC patients as compared to healthy controls (p = 0.032). Whereas the genotypes and alleles of the IL-6 rs1800795 were not significantly linked to NSCLC incidence (p = 0.726; p = 0.822, respectively). To our best knowledge, this study aimed to uncover the great impact of IL-1β rs16944 genotypes on NSCLC development in the Egyptian population; thus, it may be a gateway for earlier NSCLC prevention.

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Interleukin polymorphisms and protein levels associated with lung cancer susceptibility and phenotypes

Cited by 9 publications

References 77 publications

Variants of candidate genes associated with the risk of obstructive sleep apnea

Variants of candidate genes associated with the risk of obstructive sleep apnea

Impact of IL-10-1082A\G promoter gene polymorphism and production in lung cancer patients

Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study

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