Interleukin (IL)-10 inhibits RANTES-, tumour necrosis factor (TNF)- and nerve growth factor (NGF)-induced mast cell migratory response but is not a mast cell chemoattractant

Pietrzak, Anna; Misiak-Tłoczek, Anna; Brzezińska‐Błaszczyk, Ewa

doi:10.1016/j.imlet.2009.02.003

Cited by 16 publications

(14 citation statements)

References 54 publications

(52 reference statements)

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“…This suggests a more complex interaction than that observed for SDF-1α in vitro with mast cells. Finally, our protein analysis reveals significant reduction in some of the chemokines, such as CRG-2/CXCL10, TCA-3/CCL1, lymphotactin/CXCL1, leptin receptor, IL-13 which have been shown to trigger mast cell migration [31–33]. …”

Section: Discussionmentioning

confidence: 99%

The effect of incorporation of SDF-1α into PLGA scaffolds on stem cell recruitment and the inflammatory response

et al. 2010

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Despite significant advances in the understanding of tissue responses to biomaterials, most implants are still plagued by inflammatory responses which can lead to fibrotic encapsulation. This is of dire consequence in tissue engineering, where seeded cells and bioactive components are separated from the native tissue, limiting the regenerative potential of the design. Additionally, these interactions prevent desired tissue integration and angiogenesis, preventing functionality of the design. Recent evidence supports that mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC) can have beneficial effects which alter the inflammatory responses and improve healing. The purpose of this study was to examine whether stem cells could be targeted to the site of biomaterial implantation and whether increasing local stem cell responses could improve the tissue response to PLGA scaffold implants. Through incorporation of SDF-1α through factor adsorption and mini-osmotic pump delivery, the host-derived stem cell response can be improved resulting in 3X increase in stem cell populations at the interface for up to 2 weeks. These interactions were found to significantly alter the acute mast cell responses, reducing the number of mast cells and degranulated mast cells near the scaffold implants. This led to subsequent downstream reduction in the inflammatory cell responses, and through altered mast cell activation and stem cell participation, increased angiogenesis and decreased fibrotic responses to the scaffold implants. These results support that enhanced recruitment of autologous stem cells can improve the tissue responses to biomaterial implants through modifying/bypassing inflammatory cell responses and jumpstarting stem cell participation in healing at the implant interface.

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Section: Discussionmentioning

confidence: 99%

The effect of incorporation of SDF-1α into PLGA scaffolds on stem cell recruitment and the inflammatory response

et al. 2010

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“…10 and its production by mast cells can limit the progression of inflammatory disorders (reviewed in [87]). IL-10 affects mast cell development, survival and function [88,89] and was shown to inhibit TNF-a, RANTES and NGF-induced migration of mature mast cells [90]. In this capacity, IL-10 may reduce the inflammatory response, in part, by limiting mast cell migration in tissues [90].…”

Section: Reviewmentioning

confidence: 99%

“…IL-10 affects mast cell development, survival and function [88,89] and was shown to inhibit TNF-a, RANTES and NGF-induced migration of mature mast cells [90]. In this capacity, IL-10 may reduce the inflammatory response, in part, by limiting mast cell migration in tissues [90]. As well as molecules that directly induce trafficking of mast cells, it is becoming clear that the regulation of these chemoattractant molecules is crucial to the final localisation of these cells.…”

Section: Reviewmentioning

confidence: 99%

Mechanisms underlying the localisation of mast cells in tissues

Collington¹,

Williams²,

Weller³

2011

Trends in Immunology

105

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“…TGFβ1 is a mast cell chemoattractant [34; 35; 36], but it also blocks IL-4-induced migration [37]. Likewise, IL-10 suppresses mast cell migration [38]. We sought the effects of these and other cytokines representing the functional responses of Treg, Th1, Th2, and Th17 cells on ADAM10 expression.…”

Section: Resultsmentioning

confidence: 99%

ADAM10 is required for SCF-induced mast cell migration

Faber¹,

Pullen²,

Fernando³

et al. 2014

Cellular Immunology

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A Disintegrin And Metalloproteinase (ADAM)-10 plays critical roles in neuronal migration and distribution. Recently, ADAM10 deletion was shown to disrupt myelopoiesis. We found that inducible deletion of ADAM10 using Mx1-driven Cre recombinase for a period of three weeks resulted in mast cell hyperplasia in the skin, intestine and spleen. Mast cells express surface ADAM10 in vitro and in vivo, at high levels compared to other immune cells tested. ADAM10 is important for mast cell migration, since ADAM10-deficiency reduced c-Kit-mediated migration. As with some mast cell proteases, ADAM10 expression could be altered by the cytokine microenvironment, being inhibited by IL-10 or TGFβ1, but not by several other T cell-derived cytokines. Collectively these data show that the ADAM10 protease is an important factor in mast cell migration and tissue distribution, and can be manipulated by environmental cues.

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Interleukin (IL)-10 inhibits RANTES-, tumour necrosis factor (TNF)- and nerve growth factor (NGF)-induced mast cell migratory response but is not a mast cell chemoattractant

Cited by 16 publications

References 54 publications

The effect of incorporation of SDF-1α into PLGA scaffolds on stem cell recruitment and the inflammatory response

The effect of incorporation of SDF-1α into PLGA scaffolds on stem cell recruitment and the inflammatory response

Mechanisms underlying the localisation of mast cells in tissues

ADAM10 is required for SCF-induced mast cell migration

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