Interleukin gene polymorphisms in Chinese Han population with breast cancer, a case-control study

Abstract

Cytokines are known as important regulators of the cancer involved in inflammatory and immunological responses. This fact and plethora of gene polymorphism data prompted us to investigate IL1 gene polymorphisms in breast cancer (BC) patients. Totally, 530 patients with BC and 628 healthy control women were studied. The genetic polymorphisms for IL1 were analyzed by Massarray Sequencing method. Three single nucleotide polymorphisms (SNPs) identified in IL1B, IL1R1 gene are thought to influence breast cancer risk. The results of the association between IL-1B, IL1R1 polymorphisms and breast cancer risk have significant. We found that the variant TT genotype of rs10490571 was associated with a significantly increased breast cancer risk (TT vs. CC: OR = 2.82, 95% CI = 1.12–7.08, P = 0.047 for the codominant model). For rs16944 (AG vs. GG: OR = 0.60, 95% CI = 0.41–0.90, P = 0.034 for the codominant model) and rs1143623 (CG vs. CC: OR = 0.65, 95% CI = 0.45–0.94, P = 0.023 for the codominant model) have significant associations were found in genetic models. In conclusion, the present analysis suggests a correlation of polymorphic markers within the IL-1 gene locus with the risk in developing breast cancer. Taken together with our finding that IL1B, IL1R1 gene three SNP are also associated with the risk for the disease, we suggest that inflammation via innate and adaptive immunity contributes to multifactorial hereditary predisposition to pathogenesis of the breast cancer.

Association of the IL-1B rs1143623 Polymorphism and Cancer Risk: A Meta-Analysis

“…Nine articles that included 11 case-control studies, with 4801 cases and 6116 controls, were identified for the meta-analysis (Landvik et al, 2009;Andersen et al, 2013;Kutikhin et al, 2014;Li et al, 2015;Wang et al, 2017Wang et al, , 2019aEaton et al, 2018;Qian et al, 2018;Zuo et al, 2018). Because of studying three types of cancer, the article by Kutikhin et al (2014) was separated into three independent studies.…”

“…Moreover, linkage disequilibrium patterns in different ethnicities may be a possible reason for this phenomenon (Wu et al, 2015). It should be noted that the control groups in three articles (Kutikhin et al, 2014;Zuo et al, 2018;Wang et al, 2019a) were inconsistent with the HWE. Thus, we BC, breast cancer; CRC, colorectal cancer; GC, gastric cancer; HB, hospital-based; HWE, Hardy-Weinberg equilibrium; LC, lung cancer; MAS, mass array system; NSCLC, nonsmall-cell lung cancer; OC, ovarian cancer; PB, population-based; RCC, renal cell carcinoma; RFLP-PCR, restriction fragment length polymorphism-polymerase chain reaction; RT-PCR, real-time polymerase chain reaction.…”

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

“…However, association studies indicated that rs4851527 was associated with decreased risk of tuberculosis (Ren et al, ) and ankylosing spondylitis (Xia et al, ). No significant association was found between the two SNPs (rs3218896 and rs2072472) and risk of IgA nephropathy (Xie et al, ), tuberculosis (Ren et al, ), and breast cancer (Zuo et al, ). Moreover, no significant association was also found between rs2072472 and the risk of ankylosing spondylitis (Xia et al, ) and endometriosis (Chun et al, ).…”

IL1R1 and IL1R2 polymorphisms were associated with tuberculosis risk: A pilot study

“…The minor allele of rs10490571 was associated with an increased risk of immunoglobulin (Ig)A nephropathy and breast cancer in previous studies . Although rs956730 has been investigated in association studies on hand osteoarthritis, knee osteoarthritis and breast cancer, none of these studies showed any significant association between rs956730 and the risk of disease. Rs3917225 was reported to have no correlation with the location of papillary thyroid carcinoma in a Korean population .…”