Interleukin enhancer binding factor 2 (IEBF 2) was involved in the regulation of the antibacterial immune reactions in fresh water crayfish, Procambarus clarkii

Yang, Bing‐Bing; Lin, Sihan; Li, Bo; Wei, Zhe; Li, Qianqian; Shen, Xiu-li; Du, Zhiqiang

doi:10.1016/j.dci.2021.104226

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…For instance, interleukin enhancer-binding factor 2 (ILF2) homolog, stimulator of interferon genes (STING) protein 2, and E3 ubiquitin-protein ligase TRIM56-like were the three of the most prominently regulated proteins in deep-sea mussels when exposed to either Cd treatment, indicating that Cd can disturb the immune homeostasis in deep-sea mussels. As one of the six categories of cytokines that are inducible immune regulatory proteins, interleukin could play pivotal roles in modulating cell communication, growth, development, and differentiation to maintain immune system homeostasis (Yang et al, 2022). Although there are few reports of interleukin and its analogues in invertebrates, ILF has been reported to exist in invertebrates where it functions as regulator in some innate immune responses by affecting the Toll signaling pathway and cell apoptosis (Venier et al, 2011;Yang et al, 2022).…”

Section: Immune Response Associated With CD Exposurementioning

confidence: 99%

“…As one of the six categories of cytokines that are inducible immune regulatory proteins, interleukin could play pivotal roles in modulating cell communication, growth, development, and differentiation to maintain immune system homeostasis (Yang et al, 2022). Although there are few reports of interleukin and its analogues in invertebrates, ILF has been reported to exist in invertebrates where it functions as regulator in some innate immune responses by affecting the Toll signaling pathway and cell apoptosis (Venier et al, 2011;Yang et al, 2022). As for STING, it is well known for inducing the generation of interferon and proinflammatory cytokines.…”

Section: Immune Response Associated With CD Exposurementioning

confidence: 99%

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Toxicological effects of cadmium on deep-sea mussel Gigantidas platifrons revealed by a combined proteomic and metabolomic approach

Zhou

Li²,

Zhong³

et al. 2023

Front. Mar. Sci.

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IntroductionMarine metal contamination caused by deep-sea mining activities has elicited great concern from both social and scientific communities. Among the various metals deep-sea organisms might encounter, cadmium (Cd) is a widely detected metal that in very small amounts is nonetheless capable of severe toxicity. Yet due to both remoteness and technical challenges, insights into the effects of metal exposure resulting from mining activities upon deep-sea organisms are limited.MethodsHere, we investigated Cd’s toxicological effects on deep-sea mussels of Gigantidas platifrons exposed to 100 or 1000 g/L of Cd for 7 days; an integrated approach was used that incorporated proteomics and metabolomics along with traditional approaches (metal concentrations, metal subcellular distribution, and anti-oxidative and immune-related biochemical indexes).Results and DiscussionResults showed that Cd exposure caused significant Cd’s accumulation in mussel gills and redistribution of Cd among subcellular compartments, with cellular debris being the primary binding site. Although anti-oxidative enzymes activities (superoxide dismutase and catalase) were not significantly altered in mussel gills of both exposed groups, the markedly increased level of glutathione S-transferase detected via proteomic technique clearly evinced that deep-sea mussels suffered from oxidative stress under Cd exposure. Besides, altered activities of acid phosphatase and alkaline phosphatase assayed by traditional methods along with the predominant presence of largely altered immune-related proteins detected by proteomic data strongly revealed an immune response of deep-sea mussels elicited by Cd. In addition, results of proteomics combined with those of non-targeted metabolomics demonstrated that Cd could exert toxicity by disrupting cytoskeleton structure, ion homeostasis, and primary metabolisms of energy, lipid, and nucleotide in deep-sea mussels. As demonstrated in this study, proteomics and metabolomics can be used in tandem to provide valuable insights into the molecular mechanisms of deep-sea organisms’ response to Cd exposure and for helping to discover potential biomarkers for application during deep-sea mining assessments.

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Section: Immune Response Associated With CD Exposurementioning

confidence: 99%

Section: Immune Response Associated With CD Exposurementioning

confidence: 99%

Toxicological effects of cadmium on deep-sea mussel Gigantidas platifrons revealed by a combined proteomic and metabolomic approach

Zhou

Li²,

Zhong³

et al. 2023

Front. Mar. Sci.

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Cell Death in Crustacean Immune Defense

Chen,

Tayyab,

Yao

et al. 2024

Reviews in Aquaculture

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Cell death mechanisms in crustaceans are a complex interplay of processes essential for maintaining cellular homeostasis and immune defense. Modes of cell death like apoptosis, necroptosis, and necrosis are well‐documented in crustaceans, serving crucial roles in removing damaged or infected cells. Unlike in other organisms, crustaceans likely lack pyroptosis, a type of programmed cell death associated with innate immunity and inflammation, because they do not possess the gasdermin genes essential for this process. Recently, NETosis and ferroptosis have emerged as significant mechanisms in pathogen defense. NETosis, involving the release of DNA fibers and antimicrobial proteins, helps trap and neutralize pathogens, while ferroptosis, an iron‐dependent form of cell death, contributes to lipid peroxidation and immune responses. Cuproptosis, although not yet studied in the context of crustacean immunity, shows potential crosstalk with ferroptosis, particularly in the regulation of metal ion homeostasis, oxidative stress, and cellular metabolism. Understanding these mechanisms offers promising applications in aquaculture, such as developing targeted immune modulators and enhancing disease resistance in economically important crustacean species.

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Interleukin enhancer binding factor 2 (IEBF 2) was involved in the regulation of the antibacterial immune reactions in fresh water crayfish, Procambarus clarkii

Cited by 2 publications

References 27 publications

Toxicological effects of cadmium on deep-sea mussel Gigantidas platifrons revealed by a combined proteomic and metabolomic approach

Toxicological effects of cadmium on deep-sea mussel Gigantidas platifrons revealed by a combined proteomic and metabolomic approach

Cell Death in Crustacean Immune Defense

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