Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion

Wang, Yue; Xu, Rui; Zhang, Xiao Lei; Niu, Xiu Long; Qu, Yan; Li, Ling Zhi; Xiang, Meng

doi:10.1016/j.cyto.2012.04.013

Cited by 104 publications

(82 citation statements)

References 43 publications

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“…In this regard, fibroblasts are known to express many protumorigenic factors, including IL-6, which has been previously found to enhance proliferation of ovarian carcinoma cells. 38,49,50 Consistent with these findings, our studies suggest that blocking IL-6 inhibited fibroblast CMinduced SKOV-3 cell growth. Given these findings and the high levels of IL-6 expressed by fibroblasts, our data are consistent with a mechanism by which targeting the HU177 epitope selectively limits accumulation of a-SMA fibroblasts, thereby reducing an important source of protumorigenic factors that enhance angiogenesis and tumor growth.…”

Section: Discussionsupporting

confidence: 79%

“…Among the cytokines that were expressed at the highest levels was IL-6 (Supplemental Table S1). Interestingly, IL-6 enhances growth of ovarian carcinoma cells 49,50 ; thus, we examined whether this protumorigenic cytokine played a functional role in mediating the ability of a-SMAeexpressing fibroblast CM to stimulate proliferation of SKOV-3 tumor cells. Fibroblast CM significantly enhanced SKOV-3 tumor cell proliferation, and a function-blocking antibody directed to IL-6 inhibited this response ( Figure 8I).…”

Section: Ovarian Tumor Growth Inhibition By Hu177mentioning

confidence: 99%

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Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope

Caron

Ames

Contois

et al. 2016

The American Journal of Pathology

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Evidence suggests that stromal cells play critical roles in tumor growth. Uncovering new mechanisms that control stromal cell behavior and their accumulation within tumors may lead to development of more effective treatments. We provide evidence that the HU177 cryptic collagen epitope is selectively generated within human ovarian carcinomas and this collagen epitope plays a role in SKOV-3 ovarian tumor growth in vivo. The ability of the HU177 epitope to regulate SKOV-3 tumor growth depends in part on its ability to modulate stromal cell behavior because targeting this epitope inhibited angiogenesis and, surprisingly, the accumulation of a-smooth muscle actineexpressing stromal cells. Integrin a10b1 can serve as a receptor for the HU177 epitope in a-smooth muscle actineexpressing stromal cells and subsequently regulates Erkdependent migration. These findings are consistent with a mechanism by which the generation of the HU177 collagen epitope provides a previously unrecognized a 10 b 1 ligand that selectively governs angiogenesis and the accumulation of stromal cells, which in turn secrete protumorigenic factors that contribute to ovarian tumor growth. Our findings provide a new mechanistic understanding into the roles by which the HU177 epitope regulates ovarian tumor growth and provide new insight into the clinical results from a phase 1 human clinical study of the monoclonal antibody D93/TRC093 in patients with advanced malignant tumors. (Am J Pathol 2016 http://dx

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Section: Discussionsupporting

confidence: 79%

Section: Ovarian Tumor Growth Inhibition By Hu177mentioning

confidence: 99%

Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope

Caron

Ames

Contois

et al. 2016

The American Journal of Pathology

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“…IL6 and IL8/CXCL1 have protumorigenic effects on tumor, stromal, and immune cells (45)(46)(47). Overexpression of IL6 or IL8 in many tumors has been associated with poor prognosis (48,49).…”

Section: Discussionmentioning

confidence: 99%

CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer

Cheah

Chen

Sahoo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder cancer (BC) as a model, we found that CD14-high cancer cells express higher levels of numerous inflammation mediators and form larger tumors compared with CD14-low cells. CD14 antigen is a glycosyl-phosphatidylinositol (GPI)-linked glycoprotein and has been shown to be critically important in the signaling pathways of Toll-like receptor (TLR). CD14 expression in this BC subpopulation of cancer cells is required for increased cytokine production and increased tumor growth. Furthermore, tumors formed by CD14-high cells are more highly vascularized with higher myeloid cell infiltration. Inflammatory factors produced by CD14-high BC cells recruit and polarize monocytes and macrophages to acquire immune-suppressive characteristics. In contrast, CD14-low BC cells have a higher baseline cell division rate than CD14-high cells. Importantly, CD14-high cells produce factors that further increase the proliferation of CD14-low cells. Collectively, we demonstrate that CD14-high BC cells may orchestrate tumor-promoting inflammation and drive tumor cell proliferation to promote tumor growth.

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“…1C. Based on the microarray data and literature retrieval, IL8, which has been reported to be correlated with carcinogenesis and development (7)(8)(9), was selected as the primary target for the following examinations.…”

Section: Morphological Change Of Cafs In Breast Invasive Cancer Follomentioning

confidence: 99%

Taxotere-induced elevated expression of IL8 in carcinoma-associated fibroblasts of breast invasive ductal cancer

Rong

Kang

2017

Oncology Letters

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Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion

Cited by 104 publications

References 43 publications

Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope

Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope

CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer

Taxotere-induced elevated expression of IL8 in carcinoma-associated fibroblasts of breast invasive ductal cancer

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