Interleukin‐8 receptor‐mediated chemotaxis of normal human epidermal cells

Michel, G; Kemény, Lajos; Peter, Ralf Uwe; Beetz, Axel; Ried, Christine; Arenberger, Petr; Ruzicka, Thomas

doi:10.1016/0014-5793(92)80677-9

Cited by 110 publications

(73 citation statements)

References 11 publications

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“…IL-8 and other anti-inflammatory cytokines have been shown to act as potent chemoattractants for leucocytes, such as neutrophils and natural killer cells, thus contributing to healing processes but also stimulating inflammatory diseases such as rheumatoid arthritis, sepsis and inflammatory bowel disease [5][6][7] . Subsequent studies revealed that IL-8 also promotes the movement of cells of different lineages, such as fibroblasts and keratinocytes [8,9] . In recent years, IL-8 was reported to induce the migration of tumor cells and its expression was correlated with tumor growth, angiogenesis and metastatic potential in various human carcinomas and animal models [10][11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Rubie

Frick²,

Pfeil³

et al. 2007

WJG

104

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AIM:To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM).METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16).RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION:Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases.

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Section: Introductionmentioning

confidence: 99%

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Rubie

Frick²,

Pfeil³

et al. 2007

WJG

104

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“…Under optimal wound healing conditions, IL-8 expression declines after cell migration is complete, at which time the expression of matrix metalloproteinases and other growth factors increases, conditions favoring pseudostratification and differentiation of epithelial cells (5,6). In vitro studies have demonstrated that IL-8 is capable of stimulating human keratinocyte migration (7), is highly expressed at the leading edge of damaged epithelial layers, and enhances wound healing in vivo (8,9). IL-8 and CXCR2, the receptor for IL-8, promote matrix metalloproteinase expression (10,11).…”

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confidence: 99%

Formyl Peptide Receptor Ligands Promote Wound Closure in Lung Epithelial Cells

Shao¹,

Julián²,

Bao³

et al. 2011

Am J Respir Cell Mol Biol

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“…By this IL-8 reaches peak concentrations directly beyond the epidermis recruiting neutrophils, lymphocytes and macrophages which then become stimulated by TNF-α and IL-1 to produce IL-8 by themselves (23). IL-8 stimulates epithelial cell migration and proliferation (24,25). Thus interleukins in wound healing are involved not only in inflammatory responses but also in regulation of cell growth and migration.…”

Section: Discussionmentioning

confidence: 99%

Bereiter‐Hahn

Bernd

Beschmann

et al. 2014

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: Egg-oil (Charismon © ) is known for its beneficial action in wound healing and other skin irritancies and its antibacterial activity. The physiological basis for these actions has been investigated using cells in culture: HaCaT-cells (immortalized human keratinocytes), human endothelial cells in culture (HUVEC), peripheral blood mononuclear lymphocytes (PBML) and a full thickness human skin model (FTSM). Emphasis was on the influence of egg-oil on cell migration and IL-8 production in HaCaT cells, respiration, mitochondrial membrane potential, reactive oxygen (ROS) production and proliferation in HUVEC and HaCaT cells, cytokine and interleukin production in PBML and UV-light induced damage of FTSM. IL-8 production by HaCaT cells is stimulated by egg-oil whilst in phythemagglutinin-activated PBMLs production of the interleukins IL-2, IL-6, IL-10 and IFN-γ and TFN-α is reduced. ROS-production after H 2 O 2 stimulation first is enhanced but later on reduced. Respiration becomes activated due to partial uncoupling of the mitochondrial respiratory chain and proliferation of HaCaT and HUVEC is reduced. Recovery of human epidermis cells in FTSM after UV-irradiation is strongly supported by egg-oil. These results support the view that egg-oil acts through reduction of inflammatory processes and ROS production. Both these processes are equally important in cellular aging as in healing of chronic wounds.

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Interleukin‐8 receptor‐mediated chemotaxis of normal human epidermal cells

Cited by 110 publications

References 11 publications

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Formyl Peptide Receptor Ligands Promote Wound Closure in Lung Epithelial Cells

Cellular Responses to Egg-Oil (Charismon©)

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