1992
DOI: 10.1016/0014-5793(92)80677-9
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Interleukin‐8 receptor‐mediated chemotaxis of normal human epidermal cells

Abstract: Normal human keratinocytes show chemotactic behavior towards interleukin‐8 (IL‐8). Under physiological conditions this cylokine seems to be present in an equilibrium between monomeric and dimeric forms, as indicated by Western blotting data. Radioligand binding studies suggest that keratinocyte chemotaxis is mediated by receptors specific for IL‐8 dimers. IL‐8 rcceptor‐specific mRNA can be detected in a keratinocyte cell line by polymerase chain reaction.

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Cited by 110 publications
(73 citation statements)
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“…IL-8 and other anti-inflammatory cytokines have been shown to act as potent chemoattractants for leucocytes, such as neutrophils and natural killer cells, thus contributing to healing processes but also stimulating inflammatory diseases such as rheumatoid arthritis, sepsis and inflammatory bowel disease [5][6][7] . Subsequent studies revealed that IL-8 also promotes the movement of cells of different lineages, such as fibroblasts and keratinocytes [8,9] . In recent years, IL-8 was reported to induce the migration of tumor cells and its expression was correlated with tumor growth, angiogenesis and metastatic potential in various human carcinomas and animal models [10][11][12][13][14][15][16] .…”
Section: Introductionmentioning
confidence: 99%
“…IL-8 and other anti-inflammatory cytokines have been shown to act as potent chemoattractants for leucocytes, such as neutrophils and natural killer cells, thus contributing to healing processes but also stimulating inflammatory diseases such as rheumatoid arthritis, sepsis and inflammatory bowel disease [5][6][7] . Subsequent studies revealed that IL-8 also promotes the movement of cells of different lineages, such as fibroblasts and keratinocytes [8,9] . In recent years, IL-8 was reported to induce the migration of tumor cells and its expression was correlated with tumor growth, angiogenesis and metastatic potential in various human carcinomas and animal models [10][11][12][13][14][15][16] .…”
Section: Introductionmentioning
confidence: 99%
“…Under optimal wound healing conditions, IL-8 expression declines after cell migration is complete, at which time the expression of matrix metalloproteinases and other growth factors increases, conditions favoring pseudostratification and differentiation of epithelial cells (5,6). In vitro studies have demonstrated that IL-8 is capable of stimulating human keratinocyte migration (7), is highly expressed at the leading edge of damaged epithelial layers, and enhances wound healing in vivo (8,9). IL-8 and CXCR2, the receptor for IL-8, promote matrix metalloproteinase expression (10,11).…”
mentioning
confidence: 99%
“…By this IL-8 reaches peak concentrations directly beyond the epidermis recruiting neutrophils, lymphocytes and macrophages which then become stimulated by TNF-α and IL-1 to produce IL-8 by themselves (23). IL-8 stimulates epithelial cell migration and proliferation (24,25). Thus interleukins in wound healing are involved not only in inflammatory responses but also in regulation of cell growth and migration.…”
Section: Discussionmentioning
confidence: 99%