Interleukin-8 Production in Patients Undergoing Cardiopulmonary Bypass: The Influence of Pretreatment with Methylprednisolone

Jorens, Philippe G.; Jongh, R. De; Backer, Wilfried De; Damme, Jo Van; Overveld, F. Van; Bossaert, Leo; Walter, Paul; Herman, Arnold G.; Rampart, M.

doi:10.1164/ajrccm/148.4_pt_1.890

Cited by 110 publications

(43 citation statements)

References 43 publications

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“…A transient rise in circulating levels of IL-8 has been reported in patients during acute myocardial infraction (26) and in those undergoing cardiopulmonary bypass surgery. (27)(28)(29). In addition, IL-8 has been detected on reperfusion of ischemic lung in the rabbit (30).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.

Ivey¹,

Williams²,

Collins³

et al. 1995

J. Clin. Invest.

181

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The neutrophil chemoattractants generated in a model of myocardial infarction in the anesthetized rabbit were investigated. Coronary artery occlusion was followed by reperfusion for periods from 5 min to 4.5 h. Extracts of myocardial tissue in normal and post-ischemic zones were tested for C5a and interleukin-8 (IL-8) using specific radioimmunoassays. In the post-ischemic zone, imnunoreactive C5a was detected within 5 min and rose progressively to reach a plateau at 3-4.5 h. In contrast, immunoreactive IL-8 concentrations rose after a delay and were highest at the last time point tested, 4.5 h. Myeloperoxidase activity levels, an index of neutrophil accumulation, rose progressively as the concentrations of chemoattractants increased. Using cation exchange and reversed phase HPLC, immunoreactive C5a and IL-8 co-eluted with authentic standards. Fractions taken at the C5a and IL-8 peaks from reversed phase HPLC exhibited neutrophil aggregating activity which was neutralized by the respective antibody used in the radioimmunoassays. Depletion of circulating neutrophils virtually abolished immunoreactive IL-8 in the post-ischemic myocardial tissue. These observations suggest a sequential release of chemoattractants: the first, C5a is generated in interstitial fluid, followed by IL-8 generated by infiltrating neutrophils. Thus, over the time period studied, IL-8 generation would be expected to be indirectly dependent on C5a production. (J. Clin. Invest. 1995. 95:2720-2728

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Section: Introductionmentioning

confidence: 99%

Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.

Ivey¹,

Williams²,

Collins³

et al. 1995

J. Clin. Invest.

181

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show abstract

“…Indeed, considerable attention has been paid to the changes in pulmonary function following routine coronary artery bypass grafting (CABG) [5]. It is recognized that bypass and the resulting red cell trauma can result in the release of inflammatory mediators, which, in turn, are implicated in the aetiology of increased lung permeability following bypass [6]. In addition, a sternotomy has detrimental effects on the mechanics of lung function both by altering the mechanics of rib movement [7], and by reducing the efficiency of the thoracic muscles [8].…”

mentioning

confidence: 99%

Pulmonary diffusion impairment following heart transplantation: a prospective study

Egan

Lowe²,

Yonan³

et al. 1996

Eur Respir J

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The aim of this prospective study was to confirm whether and when a fall in gas transfer occurs following heart transplantation (HT); and to examine the potential relationship between gas transfer and haemodynamic change, immunosuppression, and cytomegalovirus (CMV) infection.The lung physiology of 34 heart transplant recipients (HTR) and 14 control patients undergoing coronary artery bypass grafting (CABG) were studied. The absolute and standardized residual values of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), residual volume (RV), forced residual volume (FRC), total lung capacity (TLC), transfer factor of the lungs for carbon monoxide (TL,CO) and carbon monoxide transfer coefficient (KCO) were measured before and at 30, 60, 90, 120 and 150 days after HT. These data were compared to haemodynamic status, graft rejection, cyclosporin levels and episodes of CMV infection. Lung function was studied in a group of patients before and 4 weeks after CABG.There was a significant fall in mean KCO after HT (pre-HT=1.29 and post-HT= 1.06 mmol·min -1 ·kPa·L -1 ) but not after CABG (pre-CABG=1.49, post-CABG=1.5 mmol·min -1 ·kPa·L -1 . No relationship was observed between gas transfer and CMV.At the latest stage following HT (150 days) there was a positive correlation between TL,CO (absolute value and standardized residual) and mean cyclosporin level (r=0.48 and r=0.44, respectively) and also between the absolute KCO and actual (r=0.56) and mean (r=0.55) cyclosporin levels. Following HT, there is an early fall in gas transfer, which is independent of the effects of surgery and bypass, implicating early immunosuppression (e.g. antithymocyte globulin/cyclosporin).

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“…Although bone marrow neutrophil release is stimulated during ECC (5,20), an early, transient neutropenia is frequently observed upon its commencement (20,22). Consequently, intraoperative sampling was commenced 32.9 Ϯ 6.2 min after ECC was established to ensure that any acute neutrophil sequestration was complete and flux between circulating and marginal neutrophil pools had reached equilibrium.…”

Section: Resultsmentioning

confidence: 99%

A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation

Orr¹,

Wilson²,

Taylor³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Acute inflammatory stimuli rapidly mobilize neutrophils from the bone marrow by shortening postmitotic maturation time and releasing younger neutrophils; however, the kinetics of this change in maturation time remains unknown. We propose a kinetic model that examines the rate of change in neutrophil average age at exit from the bone marrow during active mobilization to quantify this response and use this model to examine the temporal profile of late neutrophil phenotypic maturation. Total and CD10−/CD16lowcirculating neutrophils were quantified in cardiac surgery patients during extracorporeal circulation (ECC). Net growth in the circulating neutrophil pool occurred during the procedural (0.04 ± 0.02 × 109·l−1·min−1), warming (0.14 ± 0.02 × 109·l−1·min−1), and weaning (0.12 ± 0.06 × 109·l−1·min−1) phases of ECC. When applied to our differential equation mathematical model, these results predict that neutrophil average age at exit from the bone marrow decreased continually during ECC, resulting in average neutrophil release 8.44 ± 2.20 h earlier during the weaning phase than at the beginning of ECC sampling. Modeling of concurrent changes in CD10−/CD16lowneutrophil numbers indicates that CD10 expression is directly related to neutrophil mean age and predicts that the proportion of mobilizable postmitotic neutrophils that are CD10+increases from 64 to 81% during these sampled 8.4 h of maturation.

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Interleukin-8 Production in Patients Undergoing Cardiopulmonary Bypass: The Influence of Pretreatment with Methylprednisolone

Cited by 110 publications

References 43 publications

Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.

Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.

Pulmonary diffusion impairment following heart transplantation: a prospective study

A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation

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