Interleukin-8 predicts 60-day mortality in premature infants with necrotizing enterocolitis

Benkoe, Thomas; Reck, Carlos A.; Pones, Matthias; Weninger, M.; Gleiß, Andreas; Stift, Anton; Rebhandl, Winfried

doi:10.1016/j.jpedsurg.2013.05.068

Cited by 39 publications

(28 citation statements)

References 34 publications

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“…However, serum amyloid A has been reported to better differentiate NEC severity, particularly in combination with platelet counts (50). The proinflammatory cytokine IL-8 h also has been correlated with disease severity, discriminating between medical (N=63) and surgical (N=50) NEC (AUC 0.82), and was found to be correlated significantly with 60-day mortality (odds ratio 1.38, CI 1.14–1.67) (51), similar to previous reports for both NEC and sepsis-like syndromes (36). Other recent markers of disease severity have included the “LIT” score based on liver (L)-FABP, I-FABP, and trefoil factor 3 differentiating surgical from non-surgical NEC at the onset of disease (52); the “Totalis” score based on both clinical and serum markers (53); and the complement activation product C5a (54).…”

Section: Non-microbial Biomarkerssupporting

confidence: 86%

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

Rusconi

Good

Warner

2017

The Journal of Pediatrics

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Section: Non-microbial Biomarkerssupporting

confidence: 86%

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

Rusconi

Good

Warner

2017

The Journal of Pediatrics

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“…The same researchers then focussed specifically on IL-8, which is a chemoattractant for neutrophils and macrophages, the intestinal expression of which has been linked with NEC [19]. They showed that IL-8 is a suitable marker for preoperative risk assessment, that IL-8 levels obtained within 6 h prior to surgery correlate with the actual intraoperative disease extent [20], and that high levels correlate with 60-day mortality [21]. Interestingly, although IL-8 is in theory non-specific, whereas I-FABP, as discussed above, is specific for the gut, IL-8 may in fact be a better marker than I-FABP [22].…”

Section: Improved Diagnostic Methodsmentioning

confidence: 99%

Current Research on the Epidemiology, Pathogenesis, and Management of Necrotizing Enterocolitis

2017

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Despite decades of research on necrotizing enterocolitis, we still do not fully understand the pathogenesis of the disease, or how to prevent or how to treat it. However, as a result of recent significant advances in the microbiology, molecular biology, and cell biology of the intestine of preterm infants and infants with necrotizing enterocolitis, there is some hope that research into this devastating disease will yield some important translation into effective prevention, more rapid diagnosis, and novel therapies.

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“…188). Pre-operative serum IL-8 moreover predicted subsequent NEC severity, with 20-fold more IL-8 in pan-intestinal than in focal NEC cases (2750 versus 171 pg/ml) (Ref.…”

Section: Biomarkersmentioning

confidence: 99%

The immunological landscape in necrotising enterocolitis

Cho

Berger

Nold-Petry

et al. 2016

Expert Rev. Mol. Med.

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Necrotising enterocolitis (NEC) is an uncommon, but devastating intestinal inflammatory disease that predominantly affects preterm infants. NEC is sometimes dubbed the spectre of neonatal intensive care units, as its onset is insidiously non-specific, and once the disease manifests, the damage inflicted on the baby's intestine is already disastrous. Subsequent sepsis and multi-organ failure entail a mortality of up to 65%. Development of effective treatments for NEC has stagnated, largely because of our lack of understanding of NEC pathogenesis. It is clear, however, that NEC is driven by a profoundly dysregulated immune system. NEC is associated with local increases in pro-inflammatory mediators, e.g. Toll-like receptor (TLR) 4, nuclear factor-κB, tumour necrosis factor, platelet-activating factor (PAF), interleukin (IL)-18, interferon-gamma, IL-6, IL-8 and IL-1β. Deficiencies in counter-regulatory mechanisms, including IL-1 receptor antagonist (IL-1Ra), TLR9, PAF-acetylhydrolase, transforming growth factor beta (TGF-β)1&2, IL-10 and regulatory T cells likely facilitate a pro-inflammatory milieu in the NEC-afflicted intestine. There is insufficient evidence to conclude a predominance of an adaptive Th1-, Th2- or Th17-response in the disease. Our understanding of the accompanying regulation of systemic immunity remains poor; however, IL-1Ra, IL-6, IL-8 and TGF-β1 show promise as biomarkers. Here, we chart the emerging immunological landscape that underpins NEC by reviewing the involvement and potential clinical implications of innate and adaptive immune mediators and their regulation in NEC.

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Interleukin-8 predicts 60-day mortality in premature infants with necrotizing enterocolitis

Cited by 39 publications

References 34 publications

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

Current Research on the Epidemiology, Pathogenesis, and Management of Necrotizing Enterocolitis

The immunological landscape in necrotising enterocolitis

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