Interleukin 8 (IL-8) in the bronchoalveolar lavage fluid from patients with the adult respiratory distress syndrome (ARDS) and patients at risk for ARDS

Jorens, Philippe G.; Damme, Jo Van; Backer, Wilfried De; Bossaert, Leo; Jongh, R. F. De; Herman, Arnold G.; Rampart, M.

doi:10.1016/1043-4666(92)90025-m

Cited by 130 publications

(79 citation statements)

References 22 publications

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“…Additional up-regulation of IL-8 is caused by other proinflammatory cytokines such as IL-1␤. IL-8 is one of the most important chemotactic factors for neutrophils in the lung (21). Indeed, we find that WBC count is significantly increased in the TA of patients with HC.…”

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confidence: 48%

Relationship between Histologic Chorioamnionitis and Early Inflammatory Variables in Blood, Tracheal Aspirates, and Endotracheal Colonization in Preterm Infants

et al. 2003

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Histologic results of the placenta are usually not available within the first days of life. We identified inflammatory variables in tracheal aspirates and blood that were associated with histologic chorioamnionitis (HC). A derivation cohort consisted of 62 neonates and a validation cohort of 57 neonates with a gestational age Ͻ 31 wk and ventilated on d 1. Tracheal aspirates were taken on d 1 and on d 3, if the patient was still ventilated. HC was diagnosed by light microscopy. Logistic regression was used to identify independent factors in the derivation cohort associated with HC at d 1, 2, and 3. Model performance was studied using receiver operating characteristic curve analysis. Independent factors associated with HC were, at d 1, tracheal aspirate IL-8 Ն 917 pg/mL (odds ratio, 60.7; 95% confidence interval, 11-328); at d 2, blood C-reactive protein Ն 14 mg/L (odds ratio, 9.2; 95% confidence interval, 2-38), blood white blood cell count Ն 10,400/mm 3 (odds ratio, 7.4; 95% confidence interval, 2-28); and at d 3, blood neutrophil count Ն 4968/mm Chorioamnionitis is considered to be one of the main causes of preterm labor and has been associated with an adverse perinatal outcome (e.g. cerebral palsy and chronic lung disease) in preterm infants (1, 2). Histologic results of the examination of the placenta are usually not available within the first days of life, and prenatal diagnosis of chorioamnionitis remains difficult. An early diagnosis is difficult and can only be made in 6% to 24% of these patients by amniotic fluid culture (3). As a result of the "chronic inflammation" of fetal or maternal membranes, elevated proinflammatory cytokine levels are found in the amniotic fluid and ultimately in the fetus. These cytokines are associated with preterm labor and delivery, a fetal inflammatory response, and the associated negative outcomes (4, 5).The objective of the present study was to identify variables in the TA and blood of preterm infants, measured within the first 3 d of life, that are associated with HC in the placenta. These factors would allow us to identify infants with the highest risk of suffering from the adverse consequences of chorioamnionitis. METHODS Study population.

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confidence: 48%

Relationship between Histologic Chorioamnionitis and Early Inflammatory Variables in Blood, Tracheal Aspirates, and Endotracheal Colonization in Preterm Infants

et al. 2003

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“…KC (CXCL1) has been proposed as a functional homologue of human IL-8 and is associated with neutrophil recruitment and inflammation (34). The level of IL-8 in BALF is reported to be significantly higher in patients who subsequently develop ARDS than in patient who do not develop ARDS (35,36). Ma et al showed that the level of KC in BALF was elevated on Day 1 after intratracheal administration of bleomycin (37).…”

Section: Discussionmentioning

confidence: 99%

Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury

Nagahara

Yamamoto

Seno

et al. 2016

BST

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“…The proteoliposomes were used as the antigen for multiple rounds of soluble selections. Briefly, 80 ml of CXCR2 MPLs (»5£10 8 beads/ml) were incubated for 1 h with approximately10 12 phage particles in 1 ml of buffer (phosphate buffered saline (PBS), 1% BSA). The MPLs were washed three times with buffer, then bound phage were eluted using 50 mM Glycine buffer, pH2.2.…”

Section: Phage Display Selectionsmentioning

confidence: 99%

“…[5][6][7] Overexpression of the CXCR2 receptor or its ligands has been implicated in inflammatory diseases such as chronic obstructive pulmonary disorder, rheumatoid arthritis and respiratory distress syndrome. [8][9][10][11][12] It is also associated with the development and progression of multiple tumor types, including melanoma, glioblastoma, non-small cell lung carcinoma, prostrate, pancreatic, hepatocellular and renal carcinomas. [13][14][15][16][17][18][19][20][21][22][23][24] Thus, targeting the CXCR2 receptor with a therapeutic antibody would have potential application in multiple diseases.…”

Section: Introductionmentioning

confidence: 99%

Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes

Rossant

Carroll²,

Huang

et al. 2014

mAbs

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Interleukin 8 (IL-8) in the bronchoalveolar lavage fluid from patients with the adult respiratory distress syndrome (ARDS) and patients at risk for ARDS

Cited by 130 publications

References 22 publications

Relationship between Histologic Chorioamnionitis and Early Inflammatory Variables in Blood, Tracheal Aspirates, and Endotracheal Colonization in Preterm Infants

Relationship between Histologic Chorioamnionitis and Early Inflammatory Variables in Blood, Tracheal Aspirates, and Endotracheal Colonization in Preterm Infants

Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury

Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes

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