Interleukin-8, Cyclo-oxygenase-2, and Trefoil Factor Family 1 Gene Expression and Their Association with Helicobacter pylori Infection in the Remnant Stomach

Xing, Chengzhong; Kato, Shunji; Matsukura, Norio; Matsuda, Noriko; Xu, Hui; Takashi, En; Yamada, Nobutaka; Naito, Zenya; Tajiri, Takashi

doi:10.1007/s00595-005-3075-7

Cited by 7 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Xing et al described Helicobacter pylori infection and the refl ux of bile and pancreatic juice to be two important risk factors for secondary stomach carcinogenesis in the remnant stomach mucosa. 15 However, the mechanisms of carcinogenesis of gastric remnant cancer after distal gastrectomy remain unclear. Furthermore, no previous studies have been reported concerning the cellular or molecular mechanisms to explain the carcinogenesis of AFPproducing gastric cancers due to the small number of long-term survivors.…”

Section: Discussionmentioning

confidence: 99%

Alpha-Fetoprotein-Producing Early Gastric Cancer of the Remnant Stomach: Report of a Case

Shibata¹,

Sato²,

Kodama³

et al. 2007

Surg Today

View full text Add to dashboard Cite

A 67-year-old man initially underwent a distal gastrectomy for early gastric cancer (T1, N0, M0; Stage IA) in March 1995. During the follow-up period, an elevation of the serum alpha-fetoprotein (AFP) level (98.8 ng/ml) and a liver tumor (S4) were detected. A left hepatectomy was performed in December 1996. Immunohistochemically, AFP-positive cells were present in both the primary gastric tumor and metastasized liver tumor. The serum AFP level normalized immediately, but it elevated again to 22.4 ng/ml. An endoscopic examination revealed a protruding lesion in the remnant stomach. A total resection of the remnant stomach was performed in February 2005. The tumor was evaluated T1, N0, M0; Stage IA, with positive staining for AFP. The patient has survived without any sign of recurrence for more than 11 years after the first diagnosis of cancer. To the best of our knowledge, this is the first case of a long-term survival of AFP-producing gastric cancer with successfully resected metachronous liver metastasis and gastric remnant carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Alpha-Fetoprotein-Producing Early Gastric Cancer of the Remnant Stomach: Report of a Case

Shibata¹,

Sato²,

Kodama³

et al. 2007

Surg Today

View full text Add to dashboard Cite

show abstract

“…2). TFF1 expression in the gastric mucosa is higher in the Helicobacter pylori (Hp)-positive patients than in the Hp-negative patients, but the discrepancy is not significant [73]. Researchers discovered that TFF1 expression was independent of both age and gender [10].…”

Section: Distribution and Expressionmentioning

confidence: 98%

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Xiao

Ling

Lan

et al. 2015

Clinica Chimica Acta

View full text Add to dashboard Cite

“…16 That does not diminish the diagnostic and prognostic importance of these biomarkers for prediction of local inflammatory, degenerative, and even neoplastic diseases. 17 Tumor necrosis factor ␣ is one of the central elements of the T helper cell 1 (Th1) lymphocyte response, and its local and systemic injuring potential has been repeatedly demonstrated in connection with obesity, infections, allergy, arthritis, and immune disorders. [1][2][3][4][5][6][7][8] Within the gastrointestinal system, Crohn disease, ulcerative colitis, and human immunodeficiency virus-associated diarrhea have been widely viewed as cytokine-mediated morbidity, if not truly TNF-␣ diseases.…”

Section: Commentmentioning

confidence: 99%

“…1,2,4,5 Directly relevant to the current protocol is the connection between local Th1 profile, which includes augmented TNF-␣ output, and H pylori-triggered gastric ulcerations. [15][16][17][18] In simple gastritis, the connection has been identified as well, albeit in combination with Th2 cytokine secretion. 19 The importance of TGF-␤ for wound healing in general has been recognized for a long time, and recent investigations indicate that it may be appropriate for clinical outcome of gastric ulcerations as well.…”

Section: Commentmentioning

confidence: 99%

“…Indeed, within the context of H pylori infection, Billroth I vs II architecture influences cytokine generation, with some mediators less expressed after Billroth I anastomosis. 17 In clinical and experimental studies with the same pathogen, inflammatory molecules tended to exhibit lower concentrations in the fundus and upper corpus than in more distal regions of the stomach. 17,31 Biliary reflux also has been incriminated in augmented gastric cytokine generation.…”

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

Increased Gastric Cytokine Production After Roux-en-Y Gastric Bypass for Morbid Obesity

Faintuch¹,

Ishida²,

Jacabi³

et al. 2007

Arch Surg

View full text Add to dashboard Cite

Hypothesis: Mucosal cytokines may be involved in the process of gastric bacterial contamination that may occur after Roux-en-Y bypass for morbid obesity in both gastric chambers, with inflammation and gastritis mostly in the excluded stomach.Design: A prospective observational study in a homogeneous population with nonspecific complaints.Setting: Outpatient clinic of a large, public, academic hospital.Patients: Subjects (n=37; 26 [70.3%] female; mean±SD age, 42.4±9.9 years) seen a mean ± SD of 7.3 ±1.4 years after Roux-en-Y gastric bypass and nonoperated on morbidly obese control subjects (n = 10; 7 [70%] female; mean±SD age, 44.0 ± 8.9 years).Intervention: Enteroscopy was performed to collect samples for cytokine assays and bacteriologic studies.Main Outcome Measures: Concentrations of tumor necrosis factor ␣ and transforming growth factor ␤ in the gastric mucosa of both chambers in patients undergo-ing Roux-en-Y gastric bypass and correlation with bacterial overgrowth and Helicobacter pylori infection.Results: High microbial counts (Ͼ10 5 colony-forming units per milliliter) were detected in 22 (59.5%) and 7 (18.9%) of the 37 samples from the functional pouch and excluded reservoir, respectively; and H pylori investigation was positive in 6 of 37 samples (16.2%). The tumor necrosis factor ␣ concentration (mean±SD, 2.1±1.9 pg/g of protein) and the transforming growth factor ␤ concentration (mean±SD, 24.2±12.8 pg/g of protein) in the excluded stomach, but not in the proximal pouch, were elevated with regard to the corpus or antrum of controls, and correlation with bacterial overgrowth and with H pylori infection was demonstrated. Conclusion:Overexpression of tumor necrosis factor ␣ and transforming growth factor ␤ occurred in the distal stomach, positive cytokine correlation with microbial invasion by H pylori and nonspecific germs was seen, and further studies addressing phenotypic and genotypic changes of gastric mucosa are recommended.

show abstract

Interleukin-8, Cyclo-oxygenase-2, and Trefoil Factor Family 1 Gene Expression and Their Association with Helicobacter pylori Infection in the Remnant Stomach

Cited by 7 publications

References 34 publications

Alpha-Fetoprotein-Producing Early Gastric Cancer of the Remnant Stomach: Report of a Case

Alpha-Fetoprotein-Producing Early Gastric Cancer of the Remnant Stomach: Report of a Case

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Increased Gastric Cytokine Production After Roux-en-Y Gastric Bypass for Morbid Obesity

Contact Info

Product

Resources

About