Interleukin 8 and Anti-Chlamydia trachomatis Mucosal IgA as Urogenital Immunologic Markers in Patients with C. trachomatis Prostatic Infection

Mazzoli, Sandra; Cai, Tommaso; Rupealta, Valentina; Gavazzi, Andrea; Pagliai, Roberto Castricchi; Mondaini, Nicola; Bartoletti, Riccardo

doi:10.1016/j.eururo.2006.10.059

Cited by 84 publications

(103 citation statements)

References 24 publications

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“…Most investigators have suggested that seminal cytokines are mostly associated with the presence of leukocytes [163][164][165]. Elevated cytokine presence in the semen has been also attributed to pathogens [135,162,166]. However, there are studies in which seminal pathogens have been found to have no influence on cytokine levels [167,168].…”

Section: Role Of the Immune/autoimmune Reactionsmentioning

confidence: 99%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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The invasion of the male reproductive tract by microorganisms, and its subsequent consequences for sperm fertilizing potential, has been intensely discussed. The role of the bacteria that are responsible for the colonization and contamination of the male urogenital tract, rather than its infection, in diminished sperm parameters raises the most controversy. There are numerous premises suggesting that bacterial semen infection is associated with male infertility. However, the molecular mechanism by which the fertility is affected is complex and multifactorial, and still presents a puzzle. Some authors have suggested that direct interactions between bacteria and human spermatozoa facilitate sperm immobilization, affect sperm morphology, and thus weaken the ability of sperm to fertilize. On the other hand, the massive infiltration of activated leukocytes into the inflammatory site may be associated with impairment of sperm fertilizing potential, due to oxidative, apoptotic, and immune processes. This review presents current research trends and aims to summarize the present knowledge of semen inflammation and causative bacterial agents in the male urogenital tract, with its consequence on seminological parameters, and male fertility status.

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Section: Role Of the Immune/autoimmune Reactionsmentioning

confidence: 99%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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“…On the basis of HPV DNA PCR findings, it has been suggested that the male genitourinary tract, including sperm cells, might act as a reservoir for HPV persistence and infection (9,10). On the other hand, prostatitis--related symptoms are recognized as an important socio-economical problem and several sexually transmitted infections are linked to the presence of prostatitis-related symptoms (11,12). We investigated HPV infection prevalence in young heterosexual males with prostatitis-related symptoms in order to find a possible relationship between HPV infection and prostatitis-related symptoms.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection is not related with prostatitis-related symptoms: results from a case-control study

et al. 2014

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“…In previous studies on prostatitis by the same group, these microbes were not only present in deep genital tract tissues of men affected by CP, but were also associated with chronic inflammation. This correlation was shown by the presence of proinflammatory cytokines in exposed tissues (IL-6, IL-10 and IL-8) (70). Of note, Chlamydia trachomatis is capable of inducing modifications of sperm quality in male individuals affected by CP (71).…”

Section: Two Pivotal Macrolide Targets In the Prostate Gland: Intracementioning

confidence: 95%

Macrolides for the treatment of chronic bacterial prostatitis: An effective application of their unique pharmacokinetic and pharmacodynamic profile (Review)

et al. 2011

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Abstract. Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a permanent cure. Although fluoroquinolones are currently recommended as first-choice agents, macrolide antibiotics are emerging as a noteworthy option for the treatment of CBP. Macrolide antibiotics are characteri zed by an impressive array of distinct pharmacokinetic (PK) and pharmacodynamic (PD) properties. These properties include high intracellular accumulation in phagocytes and at sites of infection, including the prostate; broad antibiotic but also biofilm-inhibiting properties; immunomodulating and inflammation-resolving activities. These features offer particular advantages for the treatment of chronic infections of the prostate gland, which are not easily amenable to drug therapy. Macrolides may be exploited to counteract the unsatisfactory rates of clinical symptom improvement and pathogen eradication. The results of a number of clinical trials support this proposal.

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Interleukin 8 and Anti-Chlamydia trachomatis Mucosal IgA as Urogenital Immunologic Markers in Patients with C. trachomatis Prostatic Infection

Cited by 84 publications

References 24 publications

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Human papillomavirus infection is not related with prostatitis-related symptoms: results from a case-control study

Macrolides for the treatment of chronic bacterial prostatitis: An effective application of their unique pharmacokinetic and pharmacodynamic profile (Review)

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