“…Several other loci showed some evidence of association, but fell short of strict genome‐wide significance thresholds; these have been subsequently validated in larger studies. The three significant findings were simultaneously replicated in independent studies from the United Kingdom, the United States and the Nordic countries 31, 32. This opened the floodgates, with several successive studies GWAS and meta‐analysis followed in rapid succession, so that by 2011, common variants in 26 genomic loci had been associated with MS risk and independently replicated, but clearly only explained a fraction of MS risk attributable to genetic factors 33, 34, 35, 36, 37, 38, 39, 40, 41, 42.…”