Interleukin 7 is produced by murine and human keratinocytes.

Heufler, Christine; Topar, Gerda; Grasseger, A; Stanzl, Ursula; Koch, Franz; Romani, Nikolaus; Namen, Anthony E.; Schuler, Gerold

doi:10.1084/jem.178.3.1109

Cited by 176 publications

(86 citation statements)

References 24 publications

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“…IL-7 has been detected in human leprosy lesions and was particularly strongly expressed in the tuberculoid form as compared with lesions of the lepromatous form, indicating a beneficial role of IL-7 in cell-mediated immune responses against intracellular pathogens [36]. The cellular source of IL-7 production in such lesions are keratinocytes [25] and/or monocytes [36]. IL-7 is also constitutively secreted by some human B-cell lines, independent of the presence of EBV [37].…”

Section: Discussionmentioning

confidence: 99%

“…It has recently been demonstrated that IL-7 is produced by epithelial cells (e.g. keratinocytes) [25], and it has been hypothesized that IL-7 production in situ may profoundly influence the quality and magnitude of the local anti-tumour immune response [26,27]. Detection of IL-7 may further aid in characterizing the biological behaviour of colorectal cancer and the interaction between cancer cells and the immune system.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin‐7 (IL‐7) in Colorectal Cancer: IL‐7 is Produced by Tissues from Colorectal Cancer and Promotes Preferential Expansion of Tumour Infiltrating Lymphocytes

et al. 1997

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Despite increasing survival rates for patients with colorectal cancer, additional treatment options are required, including active or passive immunotherapy for patients with metastatic disease. Freshly harvested colorectal cancer specimens and in vitro cultured colorectal cancer cell lines were examined for IL-7 protein secretion in order to examine the potential role of this cytokine in the interaction between tumour cells and the host immune system. Freshly harvested colorectal cancer specimens (21/21), or normal adjacent mucosa (3/3), as well as long-term established colorectal cancer cell lines (3/4) exhibited IL-7 mRNA expression as detected by RT-PCR and confirmed by Southern Blot analysis. Freshly harvested colorectal cancer tissue (16/18), or long-term established colorectal cancer cell lines (2/4) secreted in vitro IL-7 as detected by ELISA. In contrast, breast, pancreatic, or lung cancer cell lines, as well as several haematopoietic cancer cells lines, tested negative for IL-7 mRNA and protein. The authors tested different cytokines (IL-1b, IL-2, IL-7, or a combination of IL-1b/IL-7) in vitro for the ability to expand tumour -infiltrating T lymphocytes (TIL) from individual patients (n ¼ 9) with colorectal cancer. TIL populations were tested at day 14 after in vitro propagation for phenotypic analysis by FACS and for reactivity directed against NK and LAK sensitive target cells and autologous cancer cells as measured by cytotoxicity and cytokine release. TIL obtained from colorectal cancer lesions can be efficiently expanded in the presence of IL-7, some (3/9) of which appear to exhibit autologous tumour recognition as measured by cytolytic effector functions and by detection of IFNg and TNFa release. Detection of IL-7 mRNA expression in colorectal cancer, in normal mucosa adjacent to tumour, as well as the ability of colorectal cancer tissue to secrete IL-7, raises new questions about the biology of the host / tumour interactions in colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interleukin‐7 (IL‐7) in Colorectal Cancer: IL‐7 is Produced by Tissues from Colorectal Cancer and Promotes Preferential Expansion of Tumour Infiltrating Lymphocytes

et al. 1997

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“…Interestingly, in vitro IL-7 stimulation was shown to induce CXCR4 expression by naive T cells, suggesting potential homing consequences. 14 IL-7 is constitutively produced by stromal and epithelial cells in the bone marrow, 15 thymus, 16 and lymph nodes 6,[17][18][19] but also in the skin 20 and mucosal tissues. 21 Its affinity for heparan sulfate proteoglycans (HSPGs) on the stromal cells 22,23 suggests that a higher local IL-7 concentration in productive tissues than in plasma may play a role in its functions.…”

Section: Introductionmentioning

confidence: 99%

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

Beq

Rozlan

Gautier

et al. 2009

Blood

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Interleukin-7 (IL-7), the principal cytokine implicated in thymopoiesis and peripheral T-cell homeostasis, is presently under evaluation in human diseases characterized by persistent lymphopenia. Unexpectedly, before the eventual IL-7-driven T-cell expansion, all treated patients showed a profound T-cell depletion 24 hours after injection. The current study uses the rhesus macaque model to investigate the mechanisms involved in this IL-7-induced T-cell depletion. We identify a new critical function of IL-7 that induces massive and rapid T-cell migration from the blood into various organs, including lymph nodes, parts of the intestine, and the skin. This homing process was initiated after the induction of chemokine receptor expression by circulating T cells and the production of corresponding chemokines in target organs. Finally, we demonstrate that the IL-7-induced cell cycling is initiated within these organs before T cells migrate back into the bloodstream, indicating that T-cell homing is required for in vivo IL-7 function. (Blood. 2009;114:816-825)

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“…IL-7 is critical for memory T-cell survival and is principally produced by nonhematopoietic cell types (13)(14)(15)(16). In the spleen and LNs, IL-7 is produced by gp38 + stromal cells known as fibroblastic reticular cells (FRCs) in the T-cell zone, which also produce the chemokines CCL19 and CCL21 to recruit CCR7 + T cells to that site (17).…”

mentioning

confidence: 99%

CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7– and IL-15–dependent niches

Jung

Kim

Perry

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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C-C receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward CCL19- and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes. The role of this chemokine receptor in regulating the homeostasis of effector and memory T cells during acute viral infection is poorly defined, however. In this study, we show that CCR7 expression alters memory CD8 T-cell homeostasis following lymphocytic choriomeningitis virus infection. Greater numbers of CCR7-deficient memory T cells were formed and maintained compared with CCR7-sufficient memory T cells, especially in the lung and bone marrow. The CCR7-deficient memory T cells also displayed enhanced rates of homeostatic turnover, which may stem from increased exposure to IL-15 as a consequence of reduced exposure to IL-7, because removal of IL-15, but not of IL-7, normalized the numbers of CCR7-sufficient and CCR7-deficient memory CD8 T cells. This result suggests that IL-15 is the predominant cytokine supporting augmentation of the CCR7−/− memory CD8 T-cell pool. Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7–dependent niches over IL-15–dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.

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Interleukin 7 is produced by murine and human keratinocytes.

Cited by 176 publications

References 24 publications

Interleukin‐7 (IL‐7) in Colorectal Cancer: IL‐7 is Produced by Tissues from Colorectal Cancer and Promotes Preferential Expansion of Tumour Infiltrating Lymphocytes

Interleukin‐7 (IL‐7) in Colorectal Cancer: IL‐7 is Produced by Tissues from Colorectal Cancer and Promotes Preferential Expansion of Tumour Infiltrating Lymphocytes

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7– and IL-15–dependent niches

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