Interleukin-7 Induces HIV Type 1 Outgrowth From Peripheral Resting CD4+ T Cells

Lehrman, Ginger; Ylisastigui, Loyda; Bosch, Ronald J.

doi:10.1097/00126334-200408150-00015

Cited by 29 publications

(31 citation statements)

References 19 publications

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“…In addition, IL-7 has been shown to be useful in depleting HIV reservoirs because of its ability to stimulate HIV replication from resting CD4 ϩ T cells. [50][51][52] In summary, these data highlight the potential strengths of IL-7 as immunotherapy for HIV-infected patients if it is provided as a timely addition to effective antiretroviral therapy.…”

Section: Discussionmentioning

confidence: 85%

Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys

Muthukumar

Zhou

Paiardini

et al. 2005

Blood

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Sooty mangabeys, the natural host of simian immunodeficiency virus (SIVsm), generally avoid progressive depletion of CD4 ؉ T cells and opportunistic infections associated with infection of humans (HIV) and macaques (SIVmac). The means by which the SIVsm-infected mangabeys maintain CD4 ؉ T-cell levels despite high rates of viral replication is unknown. One cytokine that has a key role in the regulation of T-cell levels is interleukin-7 (IL-7). Here, the longitudinal assessment of 6 SIVsm-infected mangabeys identified an early increase in plasma IL-7 levels at weeks 1 to 5 after infection. This IL-7 increase correlated with an early decline in CD4 ؉ T-cell levels (decline of 492-1171 cells/L) accompanying acute viremia. Elevated IL-7 levels were followed by increased T-cell proliferation (Ki67) and maintenance of lower but stable (more than 500 cells/L) CD4 ؉ T-cell levels in each mangabey through 37 weeks of infection. These data contrast with our earlier studies in SIVmac-infected macaques, in which the IL-7 increase was delayed until 20 to 40 weeks after infection, just before the onset of simian AIDS. Taken together, these data suggest that timely triggering of IL-7 is important for stabilizing healthy T-cell levels in mangabeys and that timely administration of exogenous IL-7 may show benefit during pathogenic SIVmac and HIV infection.

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Section: Discussionmentioning

confidence: 85%

Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys

Muthukumar

Zhou

Paiardini

et al. 2005

Blood

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“…The most widely discussed approach for eliminating the reservoir is the "shock and kill" approach, in which small-molecule LRAs are used to induce HIV gene expression in the hopes that the infected cells will then die as a result of viral cytopathic effects and/or natural or induced HIV-specific immune responses (17,(58)(59)(60)(61)(62)(63)(64)(65)(66). This would be done in patients on ART, and it is generally assumed that reversal of latency will not result in new infection events, given the remarkable efficacy of antiretroviral drugs (67,68).…”

Section: "Shock and Kill"mentioning

confidence: 99%

Recent developments in the effort to cure HIV infection: going beyond N = 1

Siliciano¹,

Siliciano²

2016

Journal of Clinical Investigation

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“…Studies have shown that IL-7 can induce latent virus expression ex vivo from CD4+ T-cells from patients who are receiving HAART, although to differing extents. For example, there was no statistically significant difference in viral re-expression between Il-7 and mitogen-treated latently infected CD4 cells, although IL-7 itself could induce viral recovery [160]. It was also found that IL-7 could induce the expression of unique viral isolates through activation of the JAK/STAT pathway, and could thus be of clinical significance [161].…”

Section: Induction Of Viral Expressionmentioning

confidence: 99%