Interleukin 6, serum amyloid A and haptoglobin as markers of treatment efficacy in pigs experimentally infected with Actinobacillus pleuropneumoniae

Hultén, C.; Johansson, Elin; Fossum, Caroline; Wallgren, Per

doi:10.1016/s0378-1135(03)00136-6

Cited by 50 publications

(45 citation statements)

References 22 publications

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“…In contrast serum levels of SAA which is an established acute phase indicator in pigs [12] rose one day after infection, remained high for two days and then fell back to baseline levels after 5 days. The fall in levels of TTR during the acute phase response was relatively small compared to the increases found in SAA which increased by 39 fold.…”

Section: Discussionmentioning

confidence: 83%

“…The serum level of these proteins either increases in the case of positive acute phase proteins such as haptoglobin, C-reactive protein and serum amyloid A [5] or decreases in the case of negative acute phase proteins such as transthyretin (TTR) [13,14]. The level of positive APP in porcine sera has been shown to provide an objective measure of animal health status and is becoming widely used as a gauge of animal welfare which is understood as freedom of disease and, to a certain extent stress [8,12,[17][18][19]21]. In addition, concentration of the positive acute phase proteins has been shown to be proportional to the severity of the condition so they can be used both to monitor the presence and extent of a disease in pigs [3,7] and may also be used to measure the efficacy of antibiotic treatment [12,15,16].…”

Section: Introductionmentioning

confidence: 99%

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The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

et al. 2005

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-Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 µg/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 ± 8 µg/mL (n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection. acute phase proteins / pigs / infection Streptococcus suis

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

et al. 2005

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“…Some studies have found an association between elevated pig APP concentration and decreased weight gain (Eurell et al, 1992;Dritz et al, 1996;Clapperton et al, 2005). In this trial, a wide picture of the APP response was obtained, as the study included the main pig positive APP (Lampreave et al, 1994;Gonzá lez-Ramó n et al, 1995;Heegaard et al, 1998;Hulten et al, 2003) as well as the negative APP Apo A-I (Carpintero et al, 2005) and transthyretin (Campbell et al, 2005). Some differences were observed in the behaviour of the APP studied.…”

Section: Discussionmentioning

confidence: 94%

Pig acute-phase protein levels after stress induced by changes in the pattern of food administration

Piñeiro¹,

Piñeiro²,

Morales³

et al. 2007

Animal

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A total of 240 pigs, 74 days old, half boars and half females, were included in a trial designed to assess the effect of the stress caused by changes in the pattern of food administration on the concentration of acute phase proteins (APP) and productive performance parameters. Half of the animals (pigs fed ad libitum, AL group) had free access to feed, while the rest were fed following a disorderly pattern (DIS group), in which animals had alternating periods of free access to feed and periods of no feeding, when food was removed from the feeder. The periods of free access to feed (two daily periods of 2-h duration) were randomly assigned, and varied from day to day. Total feed supplied per day was identical in both groups, and exceeded the minimal amount required for animals of these ages. Pen feed intake, individual body weights and the main positive pig APP pig major acute phase protein (Pig-MAP), haptoglobin, serum amyloid A (SAA), C-reactive protein (CRP), and the negative APP apolipoprotein A-I (ApoA-I) and transtherytin were determined every 2 weeks during the period 76 to 116 days of age. Animals fed ad libitum had better average daily gain (ADG) than DIS animals in the whole experimental period ( P , 0.01) but the differences in ADG were only produced in the two first experimental sub-periods (60 to 74 and 74 to 116 days of age), suggesting that the stress diminished when the animals get used to the DIS feeding. Interestingly differences in ADG between DIS and AL pigs were due to males, whereas no differences were observed between females. The same differences observed for ADG were found for APP. DIS males had higher Pig-MAP concentration than AL males at 74 and 116 days of age, lower ApoA-I concentration at 74 days of age and higher haptoglobin and CRP concentration at 116 days of age ( P , 0.05). The results obtained in this trial show an inverse relationship between weight gain and APP levels, and suggest that APP may be biomarkers for the evaluation of distress and welfare in pigs.

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“…Other acute phase proteins include haptoglobin, and serum amyloid A (SAA). Increased levels of a number of these acute phase proteins have been associated with respiratory diseases of domestic animals [39,66,68,113,143,144]. An excellent review of the application of the acute phase proteins in veterinary clinical chemistry is available [99].…”

Section: Serum Proteinsmentioning

confidence: 99%

Lung inflammatory responses

Thacker

2006

Vet. Res.

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Interleukin 6, serum amyloid A and haptoglobin as markers of treatment efficacy in pigs experimentally infected with Actinobacillus pleuropneumoniae

Cited by 50 publications

References 22 publications

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

Pig acute-phase protein levels after stress induced by changes in the pattern of food administration

Lung inflammatory responses

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