Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

Tsujinaka, Toshimasa; Fujita, Junya; Ebisui, Chikara; Yano, Mitsuo; Kominami, Eiki; Suzuki, Koichi; Tanaka, Keiji; Katsume, Asako; Ohsugi, Yoshiyuki; Shiozaki, Hitoshi; Monden, Morito

doi:10.1172/jci118398

Cited by 371 publications

(254 citation statements)

References 50 publications

(41 reference statements)

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“…IL-6 could affect functions of lipid and muscle cells [43,44,45]. In contrast lipid tissue is a major source of IL-6 [46,47] and possibly also of sIL-6R [48].…”

Section: Discussionmentioning

confidence: 99%

Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

et al. 2002

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Aims/hypothesis. A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. Methods. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT (n=80) were compared with non-diabetic control subjects (n=77) and patients with Type II diabetes (n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA. Results. Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, p<0.0001). Soluble IL-6 receptors potentiate IL-6 bioactivity and their concentrations were mildly increased in Type II diabetes (p<0.05). These immune changes seem relevant because IL-6 dependent acute-phase proteins C-reactive protein, serum amyloid A protein and fibrinogen were also increased in IGT and Type II diabetes. Circulating concentrations of TNF-α and its two receptors sTNF-R60 and sTNF-R80 were not increased in IGT subjects compared with the control subjects. Conclusion/interpretation. Our study shows systemic up-regulation of selected inflammatory mediators in patients with Type II diabetes and IGT. The pattern observed is non-random and fits with an IL-6 associated rather than TNF-α associated response. [Diabetologia (2002) 45:805-812]

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“…IL-6 could affect functions of lipid and muscle cells [43,44,45]. In contrast lipid tissue is a major source of IL-6 [46,47] and possibly also of sIL-6R [48].…”

Section: Discussionmentioning

confidence: 99%

Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

et al. 2002

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“…Evidence of a causative role of IL-6 in the pathogenesis of anorexia and cachexia comes from experiments reporting that treatment with anti-mouse IL-6 antibody was successful in reversing the key parameters of anorexia in mice bearing adenocarcinoma. 54,55 Elevated serum concentration of IL-6 has been reported in cancer patients. IL-6 increased in lung cancer patients and has been identified as a mediator of cachexia by the growth of a uterine cervical carcinoma (Yomoto) in nude mice.…”

Section: Interleukine -6 (Il-6)mentioning

confidence: 99%

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Jurdana

2009

Radiology and Oncology

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“…Activation of the immune system leads to production of in¯ammatory cytokines such as interleukin-1b (IL-1), tumor necrosis factor (TNF), and interleukin-6 (IL-6), which can cause amino acid export from muscle (Baracos et al, 1983;Clowes et al, 1983;Tsujinaka et al, 1996). Such a situation has been clearly demonstrated for acute illness and for chronic in¯ammatory conditions such as rheumatoid arthritis and HIV infection (Roubenoff et al, 1994).…”

Section: Humoral Factorsmentioning

confidence: 99%

Sarcopenia and its implications for the elderly

2000

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Sarcopenia is the loss of muscle mass and strength with age. Sarcopenia is a part of normal aging, and occurs even in master athletes, although it is clearly accelerated by physical inactivity. Sarcopenia contributes to disability, reduced ability to cope with the stress of a major illness, and to mortality in the elderly. The etiology of sarcopenia is unclear, but several important factors have been identi®ed. These include loss of alpha motor neurons, decline in muscle cell contractility, and several potential humoral factors, such as androgen and estrogen withdrawal and increase in production of catabolic cytokines. Treatment of sarcopenia with progressive resistance training is safe and effective, but dissemination of this technique to the general population has yet to occur. As the number of elderly persons increases exponentially in the new century, a public health approach to prevention and treatment of sarcopenia, based on increasing physical activity at all ages, will be crucial to avoiding an epidemic of disability in the future.

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Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

Cited by 371 publications

References 50 publications

Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Sarcopenia and its implications for the elderly

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