Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study

Mozaffari, Hamid Reza; Sharifi, Roohollah

doi:10.5114/ceji.2018.74880

Cited by 37 publications

(33 citation statements)

References 24 publications

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“…Lymphocyte‐mediated immune response and locally released cytokines promote keratinocyte apoptosis. Consistently, human biopsies from OLP showed extensive epithelial layer destruction and numerous infiltrated lymphocytes, accompanied by high expression of the inflammatory cytokines TNF‐α and IL‐6, confirming previous reports (Kara, ; Mozaffari et al, ) and pointing to a role of these cytokines in the pathological process of OLP. The results of down‐regulated MASPIN and up‐regulated IKKα in OLP tissues attracted our attention.…”

Section: Discussionsupporting

confidence: 89%

“…Although the cause and pathogenesis of OLP remain unclear, previous studies have clarified that its aetiology includes stress, hypersensitivity, immune response, viral and bacterial infections (Cheng, Gould, Kurago, Fantasia, & Muller, ; Jaafari‐Ashkavandi, Mardani, Pardis, & Amanpour, ). Moreover, inflammatory cytokines play an important role in the pathogenesis of OLP, such as tumour necrosis factor‐alpha (TNF‐α), interleukin (IL‐6) and IL‐17 (Gueiros et al, ; Kara, ; Mozaffari, Sharifi, & Sadeghi, ).…”

Section: Introductionmentioning

confidence: 99%

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Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus

Liu

et al. 2019

Oral Diseases

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Objectives Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear pathological mechanism. IκB kinase α (IKKα)‐regulated mammary serine protease inhibitor (MASPIN) has been shown to mediate inflammation, particularly in cancers. Here, we explored the expression of MASPIN in OLP and its role in the inflammatory response. Materials and Methods Immunohistochemistry staining and reverse transcription‐polymerase chain reaction assays were used to detect the subcellular localization and expression of MASPIN and IKKα in OLP and healthy control tissues. Levels of the inflammatory factors were compared with enzyme‐linked immunosorbent assays. MASPIN and IKKα were overexpressed and silenced, respectively, in an inflammation model of human oral keratinocytes (HOKs) stimulated with lipopolysaccharide (LPS). Results Mammary serine protease inhibitor expression was down‐regulated, whereas IKKα expression was up‐regulated in OLP tissues (p < 0.01). The levels of tumour necrosis factor‐alpha and interleukin‐6 in OLP tissues were increased compared to those of healthy controls (p < 0.01). MASPIN overexpression in LPS‐stimulated HOK cells inhibited the levels of IKKα and the secretion of inflammatory cytokines. By contrast, IKKα silencing promoted the expression of MASPIN and inhibited the secretion of inflammatory cytokines. Conclusion Both MASPIN and IKKα are involved in the inflammatory process of OLP, suggesting potential therapeutic targets.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus

Liu

et al. 2019

Oral Diseases

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“…Two meta-analyses [19,20] showed that serum and salivary cytokines (interleukin-6 and tumor necrosis factor-alpha), as important immunological factors involved in systemic inflammation, were significantly more in the OLP patients as compared to the controls. The present meta-analysis checked the serum and salivary Igs levels in OLP patients compared to controls, and showed no elevation in the serum levels.…”

Section: Discussionmentioning

confidence: 99%

Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

Mozaffari¹,

Zavattaro²,

Abdolahnejad³

et al. 2018

Preprint

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Background and Aim: Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Materials and Methods: Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the NOS questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Results: Out of 70 studies found in the databases, eight studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of  IgA, IgG, and IgM were -0.13 g/L [95%CI: -0.24, -0.02; P = 0.02], 1.01 g/L [95%CI: -0.91, 2.93; P = 0.30], and -0.06 g/L [95%CI: -0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95%CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95%CI: -0.20, 1.38; P = 0.14], respectively. Conclusions: Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had a higher diagnostic value than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

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“…Interleukin-6 is involved in B-and T-cell differentiation and is able to inactivate p53 with tumor progression of some cancers [73]. Mozaffari et al revealed in a meta-analysis that IL-6 levels in saliva and serum of OLP patients were significantly higher than in healthy controls, with higher values in saliva than in serum [74]. For this reason, saliva seemed to be more useful than serum for the detection of IL-6.…”

Section: Oral Lichen Planusmentioning

confidence: 99%

Saliva and Oral Diseases

Martina

Campanati

Diotallevi

et al. 2020

JCM

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Saliva is a fascinating biological fluid which has all the features of a perfect diagnostic tool. In fact, its collection is rapid, simple, and noninvasive. Thanks to several transport mechanisms and its intimate contact with crevicular fluid, saliva contains hundreds of proteins deriving from plasma. Advances in analytical techniques have opened a new era-called "salivaomics"-that investigates the salivary proteome, transcriptome, microRNAs, metabolome, and microbiome. In recent years, researchers have tried to find salivary biomarkers for oral and systemic diseases with various protocols and technologies. The review aspires to provide an overall perspective of salivary biomarkers concerning oral diseases such as lichen planus, oral cancer, blistering diseases, and psoriasis. Saliva has proved to be a promising substrate for the early detection of oral diseases and the evaluation of therapeutic response. However, the wide variation in sampling, processing, and measuring of salivary elements still represents a limit for the application in clinical practice.

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Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study

Cited by 37 publications

References 24 publications

Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus

Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus

Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

Saliva and Oral Diseases

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