Interleukin 6 Knock-Out Mice Are Resistant to Antigen-Induced Experimental Arthritis

Boe, Alessandra; Baiocchi, Marta; Carbonatto, Michela; Papoian, Ruben; Serlupi-Crescenzi, Ottaviano

doi:10.1006/cyto.1999.0502

Cited by 122 publications

(75 citation statements)

References 22 publications

(24 reference statements)

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“…In IL-6-knockout mice, CIA was less severe and had a delayed onset compared with CIA in wild-type mice (104). Similarly, injection with methylated bovine serum albumin induced AIA in wildtype mice but failed to induce joint swelling in IL-6-knockout mice (105). The potency of IL-6 receptor blockade was subsequently tested in animal models of arthritis.…”

Section: From Animal Models Toward the Clinicmentioning

confidence: 99%

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Bevaart¹,

Vervoordeldonk²,

Tak³

2010

Arthritis & Rheumatism

228

193

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There are accumulating data describing the association between diabetes and cancer mortality from Westernised populations. There are no data describing the relationship between diabetes and cancer mortality in African or South Asian populations from developing countries. We explored the relationship of abnormal glucose tolerance and diabetes on cancer mortality risk in a large, multi‐ethnic cohort from the developing nation of Mauritius. Population‐based surveys were undertaken in 1987, 1992 and 1998. The 9559 participants comprised 66% of South Asian (Indian), 27% of African (Creole), and 7% of Chinese descent. Cox's proportional hazards model with time varying covariates was used to obtain hazard ratios (HRs) and 95% confidence intervals (95% CI) for risk of cancer mortality, after adjustment for confounding factors. In men, but not women, cancer mortality risk increased with rising 2h‐PG levels with HR for the top versus bottom quintile of 2.77 (95%CI: 1.28 to 5.98). South Asian men with known diabetes had a significantly greater risk of cancer mortality than those with normal glucose tolerance (NGT) HR: 2.74 (95%CI: 1.00‐7.56). Overall, impaired glucose tolerance was associated with an elevated risk of cancer mortality compared to NGT (HR: 1.47, 95% CI: 0.98–2.19), though this was not significant. We have shown that the association between abnormal glucose tolerance and cancer extends to those of African and South Asian descent. These results highlight the importance of understanding this relationship in a global context to direct future health policy given the rapid increase in type 2 diabetes, especially in developing nations.

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Section: From Animal Models Toward the Clinicmentioning

confidence: 99%

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Bevaart¹,

Vervoordeldonk²,

Tak³

2010

Arthritis & Rheumatism

228

193

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“…To assess the functional consequences of enhanced binding and activation of signal transduction molecules stimulated upon ligation of RAGE by EN-RAGE, we examined production of key inflammatory and tissuedegradative mediators linked to RA [24][25][26] by MPs bearing common or variant RAGE alleles. Exposure of RAGE 82G-bearing MPs to EN-RAGE caused a significant increase in generation of TNF-alpha detected in culture supernatant compared with quiescent cultures (470 ± 53 vs 15 ± 2 pg/ml; P Ͻ 0.001) (Figure 5e).…”

Section: Rage 82s Allele Enhances Binding/signalling/gene Expression mentioning

confidence: 99%

RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response

et al. 2002

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“…In several models, IL-6 Ϫ/Ϫ mice are protected from arthritis (53)(54)(55)(56)(57). In these models, an absence or significant reduction of the inflammatory infiltrate is observed.…”

Section: Role Of Il-6 In Systemic Jiamentioning

confidence: 99%

Targeting the interleukin‐6 receptor: A new treatment for systemic juvenile idiopathic arthritis?

Benedetti¹,

Martini²

2005

Arthritis & Rheumatism

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Interleukin 6 Knock-Out Mice Are Resistant to Antigen-Induced Experimental Arthritis

Cited by 122 publications

References 22 publications

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response

Targeting the interleukin‐6 receptor: A new treatment for systemic juvenile idiopathic arthritis?

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