1999
DOI: 10.1006/cyto.1999.0502
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Interleukin 6 Knock-Out Mice Are Resistant to Antigen-Induced Experimental Arthritis

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Cited by 122 publications
(75 citation statements)
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References 22 publications
(24 reference statements)
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“…In IL-6-knockout mice, CIA was less severe and had a delayed onset compared with CIA in wild-type mice (104). Similarly, injection with methylated bovine serum albumin induced AIA in wildtype mice but failed to induce joint swelling in IL-6-knockout mice (105). The potency of IL-6 receptor blockade was subsequently tested in animal models of arthritis.…”
Section: From Animal Models Toward the Clinicmentioning
confidence: 99%
“…In IL-6-knockout mice, CIA was less severe and had a delayed onset compared with CIA in wild-type mice (104). Similarly, injection with methylated bovine serum albumin induced AIA in wildtype mice but failed to induce joint swelling in IL-6-knockout mice (105). The potency of IL-6 receptor blockade was subsequently tested in animal models of arthritis.…”
Section: From Animal Models Toward the Clinicmentioning
confidence: 99%
“…To assess the functional consequences of enhanced binding and activation of signal transduction molecules stimulated upon ligation of RAGE by EN-RAGE, we examined production of key inflammatory and tissuedegradative mediators linked to RA [24][25][26] by MPs bearing common or variant RAGE alleles. Exposure of RAGE 82G-bearing MPs to EN-RAGE caused a significant increase in generation of TNF-alpha detected in culture supernatant compared with quiescent cultures (470 ± 53 vs 15 ± 2 pg/ml; P Ͻ 0.001) (Figure 5e).…”
Section: Rage 82s Allele Enhances Binding/signalling/gene Expression mentioning
confidence: 99%
“…In several models, IL-6 Ϫ/Ϫ mice are protected from arthritis (53)(54)(55)(56)(57). In these models, an absence or significant reduction of the inflammatory infiltrate is observed.…”
Section: Role Of Il-6 In Systemic Jiamentioning
confidence: 99%