Interleukin 6, interleukin 17, disease-related and contextual factor association with depression, and its severity in patients with rheumatoid arthritis

Albeltagy, Eman Salah; Elaziz, Shaimaa Younes Abd; Abozaid, Sarah Younes; Zomor, Hala Mohamed El; Elhamed, Sally Said Abd

doi:10.1007/s10067-020-05326-7

Cited by 18 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interleukin-17 also plays an important role in rheumatoid arthritis pathogenesis. Albeltagy et al [ 27 ] examined 120 patients suffering from rheumatoid arthritis, of whom 2/3 presented depressive symptoms (BDI II 23.95 ± 8.17). Depressive symptoms were strongly associated with increased levels of, among others, IL-17 and IL-6 as well as with rheumatic disease activity [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Albeltagy et al [ 27 ] examined 120 patients suffering from rheumatoid arthritis, of whom 2/3 presented depressive symptoms (BDI II 23.95 ± 8.17). Depressive symptoms were strongly associated with increased levels of, among others, IL-17 and IL-6 as well as with rheumatic disease activity [ 27 ]. A relationship between mood disorders and exacerbation of RA was also observed by Li et al (2019).They examined 113 patients with RA and 42 healthy volunteers and evaluated them for anxiety and depression symptoms using the HADS scale.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory versus Anti-Inflammatory Profiles in Major Depressive Disorders—The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3

Gałecka

Bliźniewska-Kowalska

Orzechowska

et al. 2021

JPM

View full text Add to dashboard Cite

Background: The authors of this research study intended to verify whether there are any changes in gene expression in depressed patients without coexisting inflammatory diseases for selected immune-inflammatory factors that are particularly important in autoimmune disease pathogenesis (IL-17, IL-21, IL-23, IL-35, Foxp3). Methods: The study was carried out on a group of 190 patients with depression and 100 healthy volunteers. The severity of depressive symptoms was assessed using the Hamilton Depression Scale. RT-PCR was used to evaluate mRNA expression and ELISA was used to measure protein expression of these genes. Results: The level of gene expression for IL-17, IL-21, IL-23, and IL-35 was substantially higher in the group of patients with depression compared to the control group. The mean mRNA expression of Foxp3 was considerably reduced in patients suffering from depressive disorders. There was a statistically significant correlation between the number of hospitalizations and the expression of specific inflammatory factors. Conclusions: Expression of specific inflammatory genes may be a factor in the etiopathogenesis of depressive disorders. The duration of the disease seems to be more important for the expression of the genes in question than the severity of depression. These cytokines may affect the metabolism of neurotransmitters and neuroendocrine functions in the brain as well as be a marker and a new potential therapeutic target for recurrent depressive disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inflammatory versus Anti-Inflammatory Profiles in Major Depressive Disorders—The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3

Gałecka

Bliźniewska-Kowalska

Orzechowska

et al. 2021

JPM

View full text Add to dashboard Cite

show abstract

“…Modern immunotherapies affecting this cytokine are used in the management of psoriasis and rheumatoid arthritis (RA) [ 50 , 51 ]. Some studies reveal that biological agents targeting IL-17, used in patients with autoimmune diseases, may have a clinical efficacy in the treatment of depressive disorders [ 29 , 52 , 53 , 54 , 55 ]. This may be related to the general improvement of the clinical condition and reduction of symptoms in this group of patients, but also to the possible common inflammatory background of depression and autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity?

Bliźniewska-Kowalska

Szewczyk

Gałecka

et al. 2020

JCM

View full text Add to dashboard Cite

(1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa.

show abstract

“…32,33 According to one study, 67.5 percent of RA patients suffer from depression, with 60 percent suffering from moderate to severe depression. 34 CFS-like symptoms can be found in 40-70 percent of RA patients, with 41 percent experiencing severe fatigue. 35 The activated immuneinflammatory and nitro-oxidative pathways in that disorder may explain this high incidence of affective and CFS-like symptoms in RA.…”

Section: Introductionmentioning

confidence: 99%

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hn¹,

Ha²,

Sq³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background. Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disorder which affects the joints in the wrists, fingers, and knees. RA is often associated with depressive and anxiety symptoms as well as chronic fatigue syndrome (CFS)-like symptoms.Aim. To examine the association between depressive symptoms (measured with the Beck Depression Inventory, BDI), anxiety (Hamilton Anxiety Rating Scale, HAMA), and CFS-like (Fibro-fatigue Scale) symptoms and immune-inflammatory, autoimmune, and endogenous opioid system (EOS) markers, and lactosylceramide in RA. Methods. The serum biomarkers were assayed in fifty-nine RA and fifty-nine patients without increased psychopathology (PP) and fifty healthy controls.Results. There were highly significant correlations between the BDI, FF, and HAMA scores and severity of RA, as assessed with the DAS28-4, clinical and disease activity indices, the number of tenders and swollen joints, and patient and evaluator global assessment scores. A common latent vector (reflective model) could be extracted from the PP and RA-severity scales, which showed excellent psychometric properties. Partial least squares analysis showed that 69.7% of the variance in this common core underpinning PP and RA symptoms could be explained by the regression on immune-inflammatory pathways, rheumatoid factor, anti-citrullinated protein antibodies, CD17, and mu-opioid receptor levels. Conclusions. Depression, anxiety, and CFS-like symptoms due to RA are reflective manifestations of the phenome of RA and are mediated via the effects of the same immune-inflammatory, autoimmune, and EOS pathways and lactosylceramide that underpin the pathophysiology of RA. These PP symptoms are clinical manifestations of the pathophysiology of RA.

show abstract

Interleukin 6, interleukin 17, disease-related and contextual factor association with depression, and its severity in patients with rheumatoid arthritis

Cited by 18 publications

References 36 publications

Inflammatory versus Anti-Inflammatory Profiles in Major Depressive Disorders—The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3

Inflammatory versus Anti-Inflammatory Profiles in Major Depressive Disorders—The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3

Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity?

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Contact Info

Product

Resources

About