Interleukin-6-Induced Reciprocal Expression of SERCA and Natriuretic Peptides mRNA in Cultured Rat Ventricular Myocytes

Tanaka, Toru; Kanda, Tsugiyasu; Takahashi, Takashi; Saegusa, Seiichiro; Moriya, Junji; Kurabayashi, M

doi:10.1177/147323000403200109

Cited by 85 publications

(48 citation statements)

References 17 publications

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“…Increased IL-6 might induce the fetal gene expression pattern observed in Fig. 5A, as previous studies reported such evidence in cultured cardiac myocytes (44,45).…”

Section: Discussionsupporting

confidence: 57%

Cardiac alterations in cancer-induced cachexia in mice

et al. 2010

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Abstract. Cachexia is a common syndrome in advanced cancer patients and causes up to 22% of cancer-related deaths. It remains elusive whether cancer cachexia causes heart failure. We investigated the effect of cancer cachexia on heart function and cardiac muscle structure in a mouse model. Male CD2F1 mice were inoculated with either colon-26 adenocarcinoma cells (Tumor group) or vehicle (PBS) (No Tumor group and Pair-fed group). Heart function as measured by fractional shortening in vivo using transthoracic echocardiography was performed on day 14 after tumor or PBS inoculation. At necropsy (day 17), hearts were collected for histology, transmission electron microscopy, RT-PCR and SDS-PAGE analysis. Mice from the Tumor group displayed a significantly reduced fractional shortening compared to mice in the No Tumor and Pair-fed groups. In hearts of the Tumor mice compared to the other groups, there was marked fibrosis and transmission electron microscopy revealed disrupted myocardial ultrastructure. Gene expression of troponin I, a regulator of cardiac muscle contraction, was reduced. Moreover, both mRNA and protein levels of myosin heavy chain (MHC) were altered whereby MHC· (adult isoform) was decreased and MHCß (fetal isoform) was increased indicating reactivation of the fetal gene expression pattern. In conclusion, heart function was diminished in mice with tumorinduced cachexia, and this impaired function was associated with increased fibrosis, disrupted myocardial structure and altered composition of contractile proteins of cardiac muscle.

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“…Increased IL-6 might induce the fetal gene expression pattern observed in Fig. 5A, as previous studies reported such evidence in cultured cardiac myocytes (44,45).…”

Section: Discussionsupporting

confidence: 57%

Cardiac alterations in cancer-induced cachexia in mice

et al. 2010

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“…Whilst we think that events occuring in the first days of life happen to be much more complex representing "early transition" and should be discussed separately, we believe this data pointing to increased NT-ProBNP levels in infants with TTN with normal cardiac functions is of value. Moreover, few studies provided evidence that the secretion of natriuretic peptides is induced by cytokines and inflammatory mediators (24,25). This information might be regarded as an additional factor resulting in increased plasma peptide levels in LRTI.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Urinary Amino-Terminal Pro-Brain Natriuretic Peptide in Childhood Lower Respiratory Tract Infections: An Indicator of Clinical Severity?

İlarslan¹,

Erdeve²,

Günay³

et al. 2017

jpr

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“…Moreover, in these infants, due to prematurity, we observed the high release of FiO2 and BARO/VALU TROMA factors followed by the release of inflamed cytokines and chomocyns which determinate damage of the epithelial and endothelial cells and comsequently the decrease in the synthesis of surfactant and the production of RDS. As cytokines play a role in BNP monitoring (28), in prematurity, their increase elevates the BNP level which shows RDS frequency. In the present study, reduction of birth age was associated with the increment of serum BNP level.…”

Section: Discussionmentioning

confidence: 99%

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

et al. 2013

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Background:Respiratory distress syndrome (RDS) is considered as one of the most popular prematurity-related respiratory problems and among the most prominent reasons of deaths in preterm infants. Objectives: Brain Natriuretic Peptide (BNP) is the secret of the volume and pressure overload response of the vessels and decreases due to resistance as well as rises in systemic vessels and also in decline of pulmonary artery pressure. In the present paper, BNP is considered as a biomarker for prediction of RDS scoring. Materials and Methods: In this case, 65 preterm infants under 37 weeks with an Apgar score more than seven and 65 healthy term infants were chosen. All of them were controlled for three days in NICU and then divided into 4 groups based on the RDS scoring and intensity, as well as chest x-ray findings; normal, mild, moderate, and severe. Serum BNP of all the infants was measured through ELISA kit and a questionnaire was filled up for each infant based on his/her demographic information and clinical findings. The collected data were analyzed by SPSS software based on the independent statistical t-test, one-sided variance analysis and X2. P < 0.05 was considered as the significant. Results:The study results revealed a significant difference between the two groups regarding the pregnancy age, weight and type of delivery between cases and control groups (P ≥ 0.05); but there was no significant difference between BNP in cases and control groups (P ≤ 0.05). However, the comparison between the mean of pregnancy weight, pregnancy age, and BNP based on RDS frequency among the patients was significant (P ≥ 0.05). Conclusions:The results of this study demonstrated that serum BNP level correlates with increased RDS scoring. Therefore, it is possible to use BNP as the prediction marker for the progressive changes of RDS which occur in premature infants.

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Interleukin-6-Induced Reciprocal Expression of SERCA and Natriuretic Peptides mRNA in Cultured Rat Ventricular Myocytes

Cited by 85 publications

References 17 publications

Cardiac alterations in cancer-induced cachexia in mice

Cardiac alterations in cancer-induced cachexia in mice

Measurement of Urinary Amino-Terminal Pro-Brain Natriuretic Peptide in Childhood Lower Respiratory Tract Infections: An Indicator of Clinical Severity?

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

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