Interleukin-6 in neuro-Behçet’s disease: Association with disease subsets and long-term outcome

Akman‐Demir, Gülşen; Tüzün, Erdem; İçöz, Sema; Yeşilot, Nilüfer; Yentür, Sibel P.; Kürtüncü, Murat; Mutlu, Melike; Saruhan‐Direskeneli, Güher

doi:10.1016/j.cyto.2008.10.007

Cited by 121 publications

(71 citation statements)

References 22 publications

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“…25 Previous studies have demonstrated higher serum levels of interleukin (IL)-1β, IL-2, IL-6 and tumor necrosis factor-α (TNF-α) in BD patients than in healthy controls. [26][27][28][29] We found that all BD disease activity parameters were correlated with depression levels of the patients. Association between disease activity and depression in the patients with BD was previously investigated in only one study.…”

Section: Discussionmentioning

confidence: 99%

Disease Activity in Turkish Patients with Behçet's Disease: Association with Fatigue, Psychological Status and Quality of Life

Güler¹,

Aslan²,

Garip³

et al. 2017

Turkiye Klinikleri J Med Sci

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Section: Discussionmentioning

confidence: 99%

Disease Activity in Turkish Patients with Behçet's Disease: Association with Fatigue, Psychological Status and Quality of Life

Güler¹,

Aslan²,

Garip³

et al. 2017

Turkiye Klinikleri J Med Sci

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“…In recent years, this methodology allowed researchers to determine candidate molecules of various diseases like rheumatoid arthritis and juvenile idiopathic arthritis (11,12). It was previously shown that cytokines, such as Interleukin 1 (IL-1), Interleukin 6 (IL-6), Interleukin 12 (IL-12), Interleukin 18 (IL-18), Tumor Necrosis Factor alpha (TNF-α), and Interferon gamma (IFN-γ); chemokines, such as IL-8; cytokine receptors, such as soluble Interleukin-2 receptor (sIL2R); and chemokine antagonist and receptors were increased in peripheral blood and tissue samples of BD patients (13)(14)(15). However, even the largest comprehensive study could only investigate 17 inflammatory molecules at the same time with a microbead system in BD (16).…”

Section: Discussionmentioning

confidence: 99%

Immune and inflammatory gene expressions are different in Behçet’s disease compared to those in Familial Mediterranean Fever

et al. 2017

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Objective: The immune classification of Behçet's disease (BD) is still controversial. In this study, we aimed to compare the immune/ inflammatory gene expressions in BD with those in familial Mediterranean fever (FMF), an autoinflammatory disorder with innate immune activation.Material and Methods: CD4+ T cells and CD14+ monocytes were isolated from the peripheral blood mononuclear cells of Behçet's disease patients (n=10), FMF (n=6) patients, and healthy controls (n=4) with microbeads, and then, the mRNA was isolated. The expressions of 440 genes associated with immune and inflammatory responses were studied with a focused DNA microarray using a chemiluminescent tagging system. Changes above 1.5-fold and below 0.8-fold were accepted to be significant. Results:In BD patients, in the CD4+ T-lymphocyte subset, interleukin 18 receptor accessory protein (1.7-fold), IL-7 receptor (1.9-fold), and prokineticin 2 (2.5-fold) were all increased compared to those in FMF patients, whereas chemokine (C-X3-C motif ) receptor-1 (CX3CR1) (0.7-fold) and endothelial cell growth factor-1 (0.6-fold) were decreased. In the CD14+ monocyte population, the V-fos FBJ murine osteosarcoma viral oncogene homolog (1.5-fold), Interleukin-8 (IL-8) (2.1-fold), and Tumor Necrosis Factor alpha (TNF-α) (1.8-fold) were all increased, whereas the chemokine (C-C motif ) ligand 5 (CCL5) (0.6-fold), C-C chemokine receptor type 7 (0.6-fold), and CX3CR1 (0.7-fold) were decreased, again when compared to those in FMF. Compared to healthy controls in the CD4+ T-lymphocyte population, in both BD and FMF patients, pro-platelet basic protein and CD27 had elevated expression. In BD and FMF patients, 24 and 19 genes, respectively, were downregulated, with 15 overlapping genes between both disorders. In the CD14+ monocytes population, chemokine (C-C motif ) receptor-1 (CCR1) was upregulated both in BD and FMF patients compared to that in the controls, whereas CCL5 was downregulated. Conclusion:Immune and inflammatory gene expressions seem to be variable in both the innate (CD14+) and adaptive (CD4+) immune responses in BD and FMF patients compared to those in controls, suggesting differences in immune regulation between the two disorders.

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“…Several studies have shown higher levels of serum IL6 in active BD compared to inactive BD and HC [71,89,90], and interestingly in neuro-BD patients, IL6 was noted to be markedly elevated in the cerebrospinal fluid (CSF), but not in the sera [91,92]. Blockage of IL6 signaling with tocilizumab in BD patients despite looking promising in the treatment of neuro-BD [55][56][57][58] has revealed mixed results for non-neurological manifestations [58,59,93,94] and is currently undergoing further evaluation in controlled clinical trials.…”

Section: Interleukin-6 (Il6)mentioning

confidence: 99%

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Adeeb¹,

Khan²,

Stack³

et al. 2017

Behcet's Disease

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Behçet's disease (BD) is a type of vasculitis with many distinctive clinical manifestations and multifactorial immunopathogenesis. The cause of BD remains unknown, but it has been postulated that in a genetically predisposed or susceptible population, exogenous agents trigger the dysregulation of both autoinflammatory and autoimmune responses resulting in multisystem vasculitis. There are robust ongoing efforts across the globe to elucidate and identify signature markers to improve and assist in rapid diagnosis of the disease and to tailor the best therapy accordingly. While association of human leukocyte antigen (HLA)-B * 51 (B * 51:01 subtype) allele is well recognized as the strongest genetic susceptibility gene so far among genetically predisposed BD patients, further investigations using the latest technology have led to the identification of several novel single nucleotide polymorphisms (SNPs) and other associated genes involved in the pathogenesis. There are several "established" cytokines known to be involved in the pathogenesis of BD, which have been further implicated in the genome-wide association studies (GWAS)-based cytokine/receptor gene loci studies, as well as numerous "novel" cytokines, which are currently being studied and identified. This chapter offers insights into current knowledge and thoughts regarding the future of biomarkers in BD.

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Interleukin-6 in neuro-Behçet’s disease: Association with disease subsets and long-term outcome

Cited by 121 publications

References 22 publications

Disease Activity in Turkish Patients with Behçet's Disease: Association with Fatigue, Psychological Status and Quality of Life

Disease Activity in Turkish Patients with Behçet's Disease: Association with Fatigue, Psychological Status and Quality of Life

Immune and inflammatory gene expressions are different in Behçet’s disease compared to those in Familial Mediterranean Fever

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

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