Interleukin-6 gene polymorphism and faster progression to end-stage renal failure in chronic glomerulonephritis

Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis

“…Ryu and Kim (2012) conducted a study in Korea and found that the IL-6-634 G allele was associated with greater frequency in patients with end-stage renal disease and could be associated with patients with end-stage renal disease. We found that the IL-6 -634GG geno-type was associated with increased risk of cardiovascular events in patients on hemodialysis, which is in agreement with previous studies (Kitamura et al, 2002;Buraczynska et al, 2007;Ryu and Kim, 2012). Therefore, IL-6-634C/G appears to be associated with progression of patients with end-stage renal disease.…”

“…However, previous studies did not find an association between IL-6-174G/C polymorphism and progression of patients with end-stage renal disease (Kitamura et al, 2002;Buraczynska et al, 2007;Ryu and Kim, 2012). The discrepancy in the results may be explained by the differences in ethnicities, sample size and also by chance.…”

“…Previous studies have shown that IL-6 -634GG or G allele is a risk factor for renal disease progression (Kitamura et al, 2002;Buraczynska et al, 2007;Ryu and Kim, 2012). Kitamura et al (2002) conducted a study in Japan, and reported that IL-6 -634C/G polymorphism may be a possible genetic susceptibility factor for the progression of diabetic nephropathy.…”

“…Kitamura et al (2002) conducted a study in Japan, and reported that IL-6 -634C/G polymorphism may be a possible genetic susceptibility factor for the progression of diabetic nephropathy. Buraczynska et al (2007) conducted a study in Poland to investigate whether the SNPs in the promoter region of the IL-6 gene was associated with the development of chronic glomerulonephritis, and reported that the IL-6 -634C/G polymorphism may be a possible risk factor for faster progression of chronic glomerulonephritis to end-stage renal disease (Buraczynska et al, 2007). Ryu and Kim (2012) conducted a study in Korea and found that the IL-6-634 G allele was associated with greater frequency in patients with end-stage renal disease and could be associated with patients with end-stage renal disease.…”

The Possible Protective Role of the Il6-174GC Genotype in Dengue Fever

“…More recently, Castellucci et al [54] associated it to mucosal/ cutaneous leishmaniasis susceptibility; Budak et al [55] found it as a potential factor of susceptibility to brucellosis; Buraczynska et al [56] emphasized it as a possible risk factor for quick progression of chronic glomerulonephritis to final stage renal disease, and Moreira et al [57] associated it to periodontal disease severity.…”