Interleukin 6 gene polymorphism ‐174 is associated with the diffuse type gastric carcinoma

Abstract

The aim of this study was to assess the significance of the interleukin 6 gene polymorphism -174 in gastric cancer risk. The interleukin 6 -174 G/C (rs1800795) gene polymorphisms was analyzed in gastric cancer, peptic ulcer, and nonulcer dyspepsia patients and in healthy control subjects and the data were correlated with the histopathological features of the patients' biopsies. The interleukin 6 -174 GG and GC genotypes have been previously associated with high interleukin 6 serum levels. We discovered that the interleukin 6 -174 GG and GC genotypes are associated with an increased risk of the diffuse histologic subtype of gastric carcinomas (OR: 6.809, P = 0.034), but absent in the intestinal type carcinomas (OR: 1.109, P = 0.908). No significant associations with peptic ulcer, gastric atrophy, or intestinal metaplasia were seen. Our results demonstrate that the interleukin 6 -174 GG and GC genotypes increase the risk of the diffuse type gastric carcinoma, but not the intestinal type gastric carcinoma or its precursor conditions, including atrophy or intestinal metaplasia. Thus, interleukin 6 seems to be an important carcinogenetic factor in the diffuse type gastric adenocarcinoma and its carcinogenetic effect could be noninflammatory.

Association between IL-6 Gene (−174 & -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk

“…And IL-6 -174 CC genotype was associated with increased renal cancer risk [13] and bladder cancer risk [14]. While a case-control study from Italy reported that IL-6-174G > C polymorphism might be related to onset and progression of neuroblastoma [15] and it might be a carcinogenetic factor in the diffuse type gastric adenocarcinoma [16]. Meanwhile, as for IL-6-572C > G polymorphism, it was reported to influenced susceptibility of HBV-related hepatocellular carcinoma according to Tang S's case research [17].…”

Relationship between Helicobacter pylori infection and vomiting induced by gastrointestinal cancer chemotherapy

“…The average infection rate can be up to 54.76% . H. pylori can escape the host immune system attack by stably implanting on the gastric mucosal epithelium; it also releases toxins to damage the gastric mucosa . Studies have shown that H. pylori infection can lead to increased lymphocytes, neutrophils, immune responses and interleukins in the gastric mucosa and that interleukin‐8 (IL‐8), interleukin‐10 (IL‐10) and C‐reactive protein (CRP) can further induce a non‐specific inflammatory response by chemotaxis and the activation of neutrophils.…”

Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk

“…All controls and study subjects originated from the homogenic ethnically Finnish population. The groups have been described previously [ 13 , 14 ].…”