Interleukin‐6 g.−174G&gt;C Promoter Polymorphism Is Associated with Obesity in the EPIC‐Potsdam Study

Klipstein‐Grobusch, Kerstin; Möhlig, Matthias; Spranger, Joachim; Hoffmann, Kurt; Rodrigues, Fabio U.S.; Sharma, Arya M.; Schimrigk, К.; Pfeiffer, Andreas F. H.; Boeing, Heiner

doi:10.1038/oby.2006.3

Cited by 32 publications

(25 citation statements)

References 22 publications

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“…The -174CC genotype, which corresponds to a weaker promoter, was associated with obesity in some reports [11,12]. This association is supported by the observations that IL6 deficient mice (Il6-/-) became obese [50].…”

Section: Discussionsupporting

confidence: 68%

“…The IL6 -176 CC genotype was also found to be more common in obese subjects (P=0.02) than in controls. Either this genotype or a haplotype which includes IL6 G-174C were associated with obesity markers in some [11,12], but not all, studies [9].…”

Section: Discussionmentioning

confidence: 99%

“…hepatocyte, lymphocyte, endothelial cells). Genetic polymorphisms and plasma levels of IL6 have complex [8] and contradictory [9] relations with obesity [10][11][12], BMI (Body Mass Index) [13][14][15] and inflammation [16].…”

Section: Introductionmentioning

confidence: 99%

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Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Cimponeriu

Serafinceanu²,

Apostol

et al. 2013

Open Life Sciences

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Polymorphisms in IL6, ACE and ATR genes are associated with obesity. Torque Teno virus (TTV) seems to be able to interfere with production of some proinflammatory cytokines associated with obesity and related phenotypes. The aim of this study was to test the potential association between obesity, TTV infection and the IL6 G-174C (rs1800795), ACE I/D (rs4646994), AT1R A1166C (rs5186) polymorphisms. The polymorphisms and the presence of TTV were detected in blood samples from 150 obese and 150 normal-weight, healthy subjects using PCR based methods. IL6-174 CC genotype was more frequent in all obese patients (P=0.02) and in patients without TTV infections (P=0.03) than in controls. Obese women had more frequent TTV infections compared with normal-weight women (P=0.046). Obese subjects, regardless of gender (women P=0.03, men P=0.04), and healthy normal-weight men (P<0.01) carriers of AT1R C allele had higher triglycerides levels compared with non-carriers. The frequency of TTV in the control group (70.67%) was similar to data reported in other populations. The present study indicated that IL6-174 CC genotype and TTV infections in women could be associated with the common form of obesity.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

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Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Cimponeriu

Serafinceanu²,

Apostol

et al. 2013

Open Life Sciences

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“…171,172 The C allele of one polymorphism in the IL6 promoter, ÀG174C, has in different populations been associated with obesity and decreased risk of T2DM. [173][174][175][176] The C allele results in lower IL6 expression. 177 Furthermore, the CÀ174C genotype has been associated with lower energy expenditure and lower rate of whole-body glucose uptake.…”

Section: Pathways Controlling Lipid Storage In Adipocytesmentioning

confidence: 99%

Obesity and polymorphisms in genes regulating human adipose tissue

Dahlman

Arner

2007

Int J Obes

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Obesity is the result of an imbalance between food intake and energy expenditure resulting in the storing of energy as fat. Adipose tissue contains the largest store of energy in the body and plays important roles in regulating energy partitioning. Developments in genomics, in particular microarray-based expression profiling, have provided scientists with a number of new candidate genes whose expression in adipose tissue is regulated by obesity. Integrating expression profiles with genome-wide linkage and/or association analyses is a promising strategy to identify new genes underlying susceptibility to obesity. This article provides a comprehensive review of adipose-tissue-expressed genes implicated in predisposition to human obesity. The authors consider the following genes of particular interest: peroxisome proliferator-activated receptor gamma and, potentially, INSIG2 acting in adipogenesis; the adrenoreceptors beta 2 and 3, as well as hormone-sensitive lipase acting on lipolysis; uncoupling protein 2 acting in mitochondria energy expenditure; and among secreted molecules the cytokine tumor necrosis factor alpha and the hormone leptin. With the rapid development in genome research, we predict that additional alleles in genes regulating adipose tissue function will be established as risk factors for common obesity in the coming years. This has important implications for the prevention of obesity and may also offer new therapeutic targets.

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“…There are increasing experimental data showing that three SNPs -174G/C (rs1800795), -572C/G (rs1800796) and -6331T/C (rs10499563) and several haplotypes of the IL-6 gene are not only related to levels of plasma IL-6 but also to inflammation (10)(11)(12)(13)(14). Moreover, the IL-6 gene polymorphism is suggested to participate in the pathogenesis of obesity and modify the risk of developing obesity-related metabolic disorders, especially insulin resistance (15,16). Herein, genetic variants in the IL-6 gene play an important role in the pathogenesis of OSAS.…”

Section: Introductionmentioning

confidence: 99%

Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome

Zhang

Liu²,

Li³

et al. 2009

Int J Mol Med

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Abstract. Obesity and inflammation are known to correlate with the pathogenesis of obstructive sleep apnea syndrome (OSAS). Interleukin (IL)-6, an important regulator of obesity and inflammation, was reported to phenotypically increase in patients with OSAS. This study aimed to investigate whether genetic variants in IL-6 confer susceptibility to OSAS. The study population consisted of 151 patients with OSAS and 75 healthy controls from Southeast China. Five haplotype-tagging single nucleotide polymorphisms (tSNPs) were selected across 21 kb of the IL-6 locus using Haploview software V4.1. The tSNPs were amplified by polymerase chain reaction (PCR) and genotyped by restriction enzyme digestion followed by gel electrophoresis. Linkage disequilibrium (LD) and haplotype reconstruction were carried out by means of a SHEsis program. No distribution difference of any of the five tSNPs between OSAS patients and controls was observed. However, in nonobese individuals (n=117), the minor allele G (rs1800796) decreased risk of OSAS compared with the major allele C [odds ratio (OR), 0.48; 95% confidence interval (CI), 0.26-0.86; p=0.014], and the haplotype TG (rs1880242, rs1800796) conferred a significantly decreased risk of OSAS than single allele G (rs1800796) (OR, 0.39; 95% CI, p=0.003). Moreover, the severity of sleep-disordered breathing (measured by apnea hypopnea index) increased linearly in carriers of the C variant of IL-6 -572G/C polymorphism (14.3±5.1, 22.0±3.6 and 34.8±3.5 for GG, CG and CC, respectively; p=0.012). To the best of our knowledge, this is the first study to suggest that genetic variants in IL-6 could modify OSAS susceptibility. SNP genotyping of IL-6 is a potential strategy for detecting the risk of breathing disordered diseases in non-obese individuals.

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Interleukin‐6 g.−174G>C Promoter Polymorphism Is Associated with Obesity in the EPIC‐Potsdam Study

Cited by 32 publications

References 22 publications

Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Obesity and polymorphisms in genes regulating human adipose tissue

Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome

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