Interleukin 6 G-174C Polymorphism Influences Outcome Following Coronary Revascularization Surgery

Bittar, Mohamad; Carey, John A.; Barnard, James; Fildes, James E.; Pravica, Vera; Yonan, N.; Hutchinson, Ian V.

doi:10.1532/hsf98.20041120

Cited by 23 publications

(23 citation statements)

References 20 publications

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“…15 The study that had results contradictory to ours was based on 24 outcomes. 14 Regardless, post-operative AF is felt to be a different entity than spontaneously occurring AF, 20 and ours is the first study to examine this SNP in subjects with the more common spontaneous form.…”

Section: Discussionmentioning

confidence: 73%

Interleukin-6 and atrial fibrillation in patients with coronary artery disease: Data from the Heart and Soul Study

Marcus

Whooley

Glidden

et al. 2008

American Heart Journal

188

122

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Background-Previous studies suggest that markers of inflammation are elevated in patients with atrial fibrillation (AF). However, because inflammation has been implicated in contributing to risk of both AF and coronary artery disease (CAD), which are often present in the same populations, it is important to control for confounding by the presence of CAD. We therefore examined several biomarkers of inflammation and ultimately genotyped IL-6 polymorphisms in AF patients in a cohort of subjects with known CAD.

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Section: Discussionmentioning

confidence: 73%

Interleukin-6 and atrial fibrillation in patients with coronary artery disease: Data from the Heart and Soul Study

Marcus

Whooley

Glidden

et al. 2008

American Heart Journal

188

122

View full text Add to dashboard Cite

show abstract

“…28 On the contrary, studies by Bittar et al 29 show that patients homozygous for the G allele had a significantly lower incidence of postoperative atrial fibrillation and a shorter hospital stay. These differences might occur due to the individual genetic predisposition for developing major or minor degrees of postoperative systemic inflammatory reaction.…”

Section: Discussionmentioning

confidence: 96%

The increased plasma C-reactive protein and interleukin-6 levels in patients undergoing coronary artery bypass grafting surgery are associated with the interleukin-6−174G > C gene polymorphism

et al. 2010

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Background: The interleukin-6 (IL-6) promoter 2174G/C polymorphism (rs1800795) is associated with enhanced systemic inflammatory response to injury. However, data on the effect of this polymorphism on inflammatory markers in patients undergoing coronary artery bypass grafting surgery (CABG) are inconsistent. The aim of our study was to investigate whether 2174G/C IL-6 polymorphism affects plasma IL-6 and C-reactive protein (CRP) concentrations in patients undergoing CABG. Methods: A total of 179 consecutive white patients (77% men, aged 65 + 8.6 standard deviation [SD] y) scheduled for elective isolated CABG were studied. Pre-and postoperative CRP and IL-6 levels were analysed in relation to the 174G/C IL-6 polymorphism determined by using TaqMan single-nucleotide polymorphism genotyping technique. Results: The genotype distribution was as follows: GG -46 (26%), GC -93 (52%) and CC -40 (22%). The C allele carriers had higher baseline CRP (4.1 + 0.35 versus 2.4 + 0.59 mg/L, P ¼ 0.02) and IL-6 levels (3.0 + 0.17 versus 2.2 + 0.3 pg/mL, P ¼ 0.02) than GG patients. Five to seven days after CABG, CRP levels rose by 54% (P ¼ 0.03), and IL-6 levels tended to be higher (P ¼ 0.07) in 2174C allele carriers than the non-carriers. There were no associations between 2174G/C IL-6 polymorphism and any demographic-, clinical-or procedure-related variables as well as major adverse cardiovascular events. Multivariate regression analysis, including sex, age, body mass index, hypercholesterolaemia, smoking, hypertension diabetes, identified CG þ CC genotype as the only independent predictor of preoperative CRP and IL-6 levels. Conclusions: The presence of the 2174C allele determines to some extent higher plasma CRP and IL-6 concentrations pre-and postoperatively in CABG patients.

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“…For example, in the studies of Humphries et al (17), it was the Ϫ174C allele carriers that had the increased risk of higher systolic blood pressure and coronary heart disease. In addition, it was the Ϫ174C allele carriers that produced in vivo the highest amount of IL-6 and had less favorable outcome of coronary revascularization surgery than the GG homozygotes (18).…”

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confidence: 99%

The −174GG Interleukin-6 Genotype Is Protective From Retinopathy and Nephropathy in Juvenile Onset Type 1 Diabetes Mellitus

et al. 2009

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ABSTRACT:The aim of our study was to determine an association between the Ϫ174GϾC IL-6 polymorphism (rs1800795) and occurrence of retinopathy and nephropathy in type 1 diabetes mellitus (T1DM) patients. Two hundred ten children/adolescents with longstanding T1DM (16.5 Ϯ 3.8 y; with diabetes duration of 8.4 Ϯ 3.0 y) were enrolled into the study. A group of 170 healthy young (16.9 Ϯ 5.2 y) sex-matched volunteers was qualified as the control. The IL-6 polymorphism was genotyped with the PCR-RFLP method. Serum and urine IL-6 concentrations were measured by the ultra-sensitive ELISA tests. The Ϫ174GG genotype was under represented in the diabetic patients compared with the controls. Patients with this genotype were free from nephropathy and retinopathy. The group of Ϫ174GG carriers was characterized by the highest urine IL-6 concentrations in relation to other genotypes. In the multivariate logistic regression analysis adjusted for age, duration of the disease, age of disease onset, HbA1c, and albumin excretion rate, the Ϫ174GG genotype was the only independent variable that significantly decreased the risk of jointly analyzed retinopathy and nephropathy [OR ϭ 0.65; 95% CI ϭ 0.52-0.82; p ϭ 0.0003]. We propose that the Ϫ174GG patients are protected from late diabetic complications by different IL-6 dependent mechanisms. (Pediatr Res 66: 341-345, 2009)

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Interleukin 6 G-174C Polymorphism Influences Outcome Following Coronary Revascularization Surgery

Abstract: The C allele is associated with higher postoperative IL-6 levels and a less favorable clinical outcome. The G-174C polymorphism is related to the outcome after coronary revascularization.

Cited by 23 publications

References 20 publications

Interleukin-6 and atrial fibrillation in patients with coronary artery disease: Data from the Heart and Soul Study

Interleukin-6 and atrial fibrillation in patients with coronary artery disease: Data from the Heart and Soul Study

The increased plasma C-reactive protein and interleukin-6 levels in patients undergoing coronary artery bypass grafting surgery are associated with the interleukin-6−174G > C gene polymorphism

The −174GG Interleukin-6 Genotype Is Protective From Retinopathy and Nephropathy in Juvenile Onset Type 1 Diabetes Mellitus

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