Interleukin-6 Expression in Patients with Frailty Syndrome

Abstract

Frailty is an age-related biological syndrome characterized by a decrease in physiological capacity and stress resistance as a result of a gradual decline in the body's physiological systems. Frailty syndrome is categorized into three categories: robust / fit, pre-frail, and frail. As a crucial aspect of immunosenescence, the presence of chronic "inflamm-aging" systemic inflammation characterizes aging. Proinflammatory cytokines, such as IL-6, increased in response to a rise in molecular inflammation as people got older. The goal of this study was to investigate the levels of IL-6 in older people dependent on their frailty status.
 Methods: This study used a cross-sectional design with 90 patients with frailty syndrome aged >=60 years who met the research requirements at Wahidin Sudirohusodo Hospital Makassar's Geriatric Polyclinic. The Cardiovascular Health Study (CHS) scoring system is used to assess frailty syndrome. The Anova and Kruskal-Wallis tests were used in the statistical analysis, and the results were considered significant if the p-value was less than 0.05.
 Results: Males made up the majority of the participants (54.4%), while females made up the rest (45.6 percent ). The most common form of weakness is frailty (43.3 percent ). Frail people had the highest levels of interleukin-6 (31.1213.40), compared to pre-frail people (22.503.29) and robust people (18.532.04). There was a statistically significant difference. Age >=70 years (27.019.02) and age 60-69 years (24.7110.94) had higher IL-6 levels. There was a statistically significant difference. Only at the age of 60-69 years did IL-6 levels change significantly between robust, pre-frail, and frail people.
 Conclusions: In subjects 60-69 years old, IL-6 levels increased in proportion to the severity of frailty. Interleukin-6 levels did not vary according to the severity of frailty status in population over the age of 70