Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Carolin Christina Drost,
Alexandros Rovas,
Irina Osiaevi
et al.
Abstract:Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC damage remain poorly defined. Aim of this study was to combine sublingual video-microscopy, plasma proteomics and live cell imaging to uncover further pathways of eGC damage in patients with coronavirus disease 2019 (COVID-19) or bacterial sepsis. This secondary analysis of the prospective multicenter MI… Show more
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