Interleukin-6 concentrations in neonates evaluated for sepsis

Doellner, Henrik; Arntzen, Knut Jørgen; Haereid, Per E.; Aag, Solrun; Austgulen, Rigmor

doi:10.1016/s0022-3476(98)70448-2

Cited by 120 publications

(96 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[3][4][5][6] Several studies have evaluated the role of cytokine determinations as early diagnostic markers in neonatal sepsis. [7][8][9][10][11][12][13] Although promising data have been published, problems with invasiveness, response time, and specificity remain to be solved. 7,8,14 -17 In sepsis, cytokines are involved in activating vascular and endothelial defense mechanisms that may cause changes in perfusion and vascular resistance in the microcirculation.…”

mentioning

confidence: 99%

Reactive Hyperemia and Interleukin 6, Interleukin 8, and Tumor Necrosis Factor-α in the Diagnosis of Early-Onset Neonatal Sepsis

2001

View full text Add to dashboard Cite

ABSTRACT. Objective. To evaluate the diagnostic value of peripheral circulatory reactive hyperemia and serum levels of interleukin-6 (IL-6), IL-8, and tumor necrosis factor-␣ (TNF-␣) in early-onset neonatal sepsis.Methods. Reactive hyperemia in the dorsal hand and serum levels of IL-6, IL-8, and TNF-␣ were studied in newborn infants (n ‫؍‬ 32; gestational age 39 ؎ 3 weeks) who had been admitted to the neonatal unit because of suspected sepsis <48 hours after birth. On admission, reactive hyperemia after a standardized arterial occlusion was measured with laser Doppler technique, and blood samples were taken for cytokine analyses. On the basis of predetermined criteria, the infants subsequently were classified as septic (n ‫؍‬ 12) or not (n ‫؍‬ 20).Results. The degree of reactive hyperemia was higher in the group with sepsis (median ؉ 170% perfusion increase) than in that without (؉37%). On admission, serum levels of IL-6, IL-8, and TNF-␣ all were higher in septic (median values: 1620, 331, and 22 pg/mL, respectively) than in nonseptic neonates (median values: 42, 63, and 13 pg/mL, respectively). In the group with sepsis, the degree of reactive hyperemia correlated to log IL-6 (r ‫؍‬ 0.80) and log IL-8 values (r ‫؍‬ 0.71).Conclusion. Newborn infants with septicemia have increased reactive hyperemia and elevated cytokine levels very early in their disease. Reactive hyperemia in skin can be analyzed at the bedside and noninvasively and therefore may serve as an additional diagnostic tool in neonatal sepsis. Pediatrics 2001;108(4). URL: http://www. pediatrics.org/cgi/content/full/108/4/e61; neonatal sepsis, newborn infant, interleukin-6, interleukin-8, TNF-␣, reactive hyperemia, diagnostic marker.ABBREVIATIONS. CRP, C-reactive protein; WBC, white blood cell count; IL-6, interleukin 6; TNF-␣, tumor necrosis factor-␣; IL-8, interleukin 8; LD, laser Doppler; PPV, positive predictive value; NPV, negative predictive value; ROC, receiver-operating characteristic curve; RDS, respiratory distress syndrome; GBS, group B streptococci. S erious infections are still causing significant morbidity and mortality among newly born infants. Immediately after birth, the clinical picture of neonatal sepsis is difficult to distinguish from more benign conditions. Rapid and reliable diagnostic tools are not yet available at the bedside. Because a delay in instituting antibiotic therapy may have adverse consequences in cases of true neonatal sepsis, in many cases decisions to treat are based on risk factors and nonspecific signs and symptoms.Experienced neonatologists and nurses recognize that in infants with sepsis, a poor peripheral circulation with a gray skin color often precedes more alarming symptoms, such as arterial hypotension and circulatory failure. Specific deviations in peripheral vascular reactivity have been found in late neonatal sepsis, 1 even before traditional markers, such as C-reactive protein (CRP) elevation and changes in white blood cell count (WBC) in peripheral blood, indicate serious infection. The advantages of...

show abstract

mentioning

confidence: 99%

Reactive Hyperemia and Interleukin 6, Interleukin 8, and Tumor Necrosis Factor-α in the Diagnosis of Early-Onset Neonatal Sepsis

2001

View full text Add to dashboard Cite

show abstract

“…[30][31][32][33] However, the current literature provides a growing body of evidence suggesting the so far reported characteristics of CRP may not be as suitable for the use in preterm as in term newborns. [34][35][36] Furthermore, the use of CRP in neonatal sepsis is complicated by a nonspecific rise that starts shortly after birth. [37,38] Any elevation of serum CRP in the neonate always represents endogenous synthesis, since it passes the placenta in exceedingly low quantities.…”

Section: C-reactive Proteinmentioning

confidence: 99%

Challenges in the Diagnosis of Sepsis of the Neonate

Resch¹,

Hofer²,

Müller³

2012

Sepsis - An Ongoing and Significant Challenge

View full text Add to dashboard Cite

“…[2] IL-6 is a pleiotropic cytokine involved in many aspects of the immune response. [3] It is known that IL-6 is an important mediator of host response to stress and infection. [4,5] There are some promising studies revealing IL-6 alone or in combination with CRP as good markers in the diagnosis of early onset neonatal sepsis.…”

Section: Original Article / Klinik çAlışma -Araştırmamentioning

confidence: 99%

“…[4,5] There are some promising studies revealing IL-6 alone or in combination with CRP as good markers in the diagnosis of early onset neonatal sepsis. [2,3] However, to our knowledge, there is no study yet for differential diagnosis of TTN and neonatal sepsis using CRP and IL-6 combination in the literature. This retrospective study aims to investigate CRP and IL-6 levels in neonates with sepsis and respiratory disorders in order to evaluate the usefulness of these parameters in distinguishing between perinatal bacterial infections and TTN in clinical practice in a newborn intensive care unit.…”

Section: Original Article / Klinik çAlışma -Araştırmamentioning

confidence: 99%

Serum Interleukin-6 Levels In Differential Diagnosis Of Sepsis And Transient Tachypnea Of Newborn

Uraş¹,

Karadağ²,

Tonbul³

et al. 2009

TUTFD

View full text Add to dashboard Cite

Objectives:The aim of this study was to evaluate the role of serum interleukin-6 (IL-6) levels in the differentiation of neonatal bacterial sepsis and TTN. Patients and Methods:The hospital records of 58 newborns with respiratory distress that were above 35 weeks of gestational age were investigated. Patients were divided into two groups. The infection group consisted of patients with proven sepsis and clinical sepsis and the remaining one was TTN group. Clinical findings and white blood cell count, serum C-reactive protein (CRP), IL-6 levels and the ratio of immature neutrophils to total neutrophils count (I/T) were recorded and were compared between the two groups.Results: Serum CRP and IL-6 levels were found higher than normal limits in both of the groups. However there was no significant difference between them. Duration of respiratory distress was longer and I/T ratio was significantly higher in the infection group than TTN group.Conclusion: I/T ratio and IL-6 may contribute to the early diagnosis of sepsis with respiratory symptoms in newborn but IL-6 alone can not distinguish TTN and sepsis.Key words: Interleukin 6; sepsis; newborn; transient tachypnea.Amaç: Bu çalışmanın amacı yenidoğanlarda serum interlökin 6 düzeyinin bakteriyel sepsis ve yenidoğanın geçici takipnesinin ayrımında rolünün araştı-rılmasıdır. Hastalar ve Yöntemler:Solunum sıkıntısı olan ve gestasyonel yaşı 35 haftadan büyük olan 58 yenidoğan çalışmaya alındı. Hastalar, kanıtlanmış veya klinik sepsisi olanlar ve yenidoğanın geçici takipnesi olanlar olmak üzere iki gruba ayrıldı. Klinik bulgular beyaz küre sayısı, C reaktif protein, serum IL-6 düzeyi, periferik yaymada immature nötrofil sayısının toplam nötrofil sayısına oranı kaydedilerek gruplar arasında karşılaştırıldı. Bulgular:Her iki grupta da serum CRP ve IL-6 düzeyleri normal limitlerden yüksek bulunmasına rağmen iki grup arasında fark yoktu. Solunum sıkıntı-sının süresi ve I/T oranı yenidoğanın geçici takipnesi olan grupta belirgin olarak fazla bulundu.Sonuç: IL-6 ve I/T oranı solunum sıkıntısı olan sepsisli yenidoğanların erken tanısı konusunda katkıda bulunurken IL-6 düzeyi tek başına yenidoğanlarda sepsis ve yenidoğanın geçici takipnesinde kullanı-lamaz.Anahtar sözcükler: İnterlökin 6; sepsis; yenidoğan; yenidoğanın geçici takipnesi.

show abstract

Interleukin-6 concentrations in neonates evaluated for sepsis

Cited by 120 publications

References 17 publications

Reactive Hyperemia and Interleukin 6, Interleukin 8, and Tumor Necrosis Factor-α in the Diagnosis of Early-Onset Neonatal Sepsis

Reactive Hyperemia and Interleukin 6, Interleukin 8, and Tumor Necrosis Factor-α in the Diagnosis of Early-Onset Neonatal Sepsis

Challenges in the Diagnosis of Sepsis of the Neonate

Serum Interleukin-6 Levels In Differential Diagnosis Of Sepsis And Transient Tachypnea Of Newborn

Contact Info

Product

Resources

About