Interleukin 6: biological significance and role in inflammatory bowel diseases

Pawłowska-Kamieniak, Agnieszka; Krawiec, Paulina; Pac-Kożuchowska, Elżbieta

doi:10.17219/acem/130356

Cited by 20 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most importantly, we have shown that increased systemic IL-6 had strong association with altered human gut resistome in GW Veterans. IL-6 has been shown to be a pleiotropic cytokine and is key to gastrointestinal disturbances, and cognitive deficits 42 , 43 . Recent advances in understanding the host resistome improved our knowledge about evolution, origins and emergence of antibiotic resistance though the field is continuously evolving 44 .…”

Section: Discussionmentioning

confidence: 99%

Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

et al. 2022

View full text Add to dashboard Cite

Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal healthy controls. The altered resistome and gene signature is correlated with mouse serum IL-6 levels. Altered resistome in mice also is correlated strongly with intestinal inflammation, decreased synaptic plasticity, reversible with fecal microbiota transplant (FMT). The results reported might help in understanding the risks to treating hospital acquired infections in this population.

show abstract

Section: Discussionmentioning

confidence: 99%

Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The main factor responsible for the altered iron metabolism in IBD is hepcidin, whose secretion is induced by inflammatory cytokines (IL-1β and IL-6). 3 , 16–18 , 38 Hepcidin acts by binding to the only known iron exporter protein FPN-1, causing its internalization and degradation. 14 , 39 Accordingly, we observed a decrease of FPN-1 in both patients with CD and UC, as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 2 Altered cytokine production has a pivotal role in the pathogenesis of IBD, causing an inflammatory state both at local and systemic levels. 3 , 4 In 10% to 40% of cases, patients with IBD present extraintestinal manifestations, 5 , 6 among which the most frequent are those affecting the bone tissue, such as osteoporosis (OP). 7 , 8 Bone mass is mostly acquired during childhood, and the early onset of IBD may compromise the final bone mineral density, affecting growth.…”

Section: Introductionmentioning

confidence: 99%

Effects of CB2 and TRPV1 Stimulation on Osteoclast Overactivity Induced by Iron in Pediatric Inflammatory Bowel Disease

Tortora

Paola

Creoli

et al. 2022

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

Background The reduction of bone mineral density and osteoporosis have high impacts on the health of patients with inflammatory bowel diseases (IBD). We have previously shown that a dysregulated iron metabolism occurs in IBD and leads to a decrease in circulating iron concentration and excessive intracellular sequestration of iron. Studies suggest that iron overload significantly affects the bone, accelerating osteoclast (OC) differentiation and activation, promoting bone resorption. Moreover, we demonstrated that iron overload causes OC overactivity. The cannabinoid receptor type 2 (CB2) and the transient receptor potential vanilloid type-1 (TRPV1) are potential therapeutic targets for bone diseases. The aim of this study was to evaluate the roles of CB2 and TRPV1 receptors and of iron in the development of osteoporosis in pediatric IBD. Methods We differentiated OCs from peripheral blood mononuclear cells of patients with IBD and healthy donors and evaluated CB2 and TRPV1 receptor expression; OC activity, and iron metabolism by Western blot, TRAP assays, bone resorption assays, and iron assays. Moreover, we analyzed the effects of the pharmacological modulation of CB2 and TRPV1 receptors on OC activity and on the iron metabolism. Results We confirmed the well-known roles of CB2 and TRPV1 receptors in bone metabolism and suggested that their stimulation can reduce the OC overactivity induced by iron, providing new insights into the pathogenesis of pediatric IBD-related bone resorption. Conclusions Stimulation of CB2 and TRPV1 could reduce IBD-related osteoporosis due to their direct effects on OC activity and to modulating the iron metabolism.

show abstract

“…We also linked the association of systemic inflammation and an altered gut resistome that is linked to increased circulating proinflammatory cytokine IL6, intestinal pathology and neurotrophic factor BDNF. IL6 has been shown to be a pleiotropic cytokine and is key to gastrointestinal disturbances, and cognitive deficits [53], [54]. Recent advances in understanding the host resistome improved our knowledge about evolution, origins and emergence of antibiotic resistance though the field is still evolving [55].…”

Section: Discussionmentioning

confidence: 99%

Gut resistome presents a unique biome signature in chronic multi-symptom illness patients and links persistent pro-inflammatory phenotype in a mouse model reversible by fecal microbiota transfer

Bose¹,

Chatterjee²,

Older³

et al. 2021

Preprint

View full text Add to dashboard Cite

Chronic multi-symptom illness (CMI) affects a subsection of elderly and war veterans and is associated with systemic inflammation, chronic fatigue, pain and neuroinflammation. We showed previously that an altered gut microbiome-inflammation axis aids to the symptom reporting and persistence. Here, a mouse model of CMI and a group of Gulf War veterans’ with CMI showed the presence of an altered host resistome, a signature of antibiotic resistance genes within the microbiome. Results showed that antibiotic resistance genes were significantly altered in the CMI group in both mice and GW veterans when compared to the control. Fecal samples from GW veterans with persistent CMI showed a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements distinct than normal healthy controls. Strikingly, the altered resistome and gene signature were correlated with mouse serum IL6 levels. Altered resistome in mice also correlated strongly with intestinal inflammation, decreased synaptic plasticity that was reversible with fecal microbiota transplant (FMT), a tool to restore a healthy biome. The results indicate an emerging linkage of the gut resistome and CMI and might be significant in understanding the risks to treating hospital acquired infections in this population.

show abstract

Interleukin 6: biological significance and role in inflammatory bowel diseases

Cited by 20 publications

References 29 publications

Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

Effects of CB2 and TRPV1 Stimulation on Osteoclast Overactivity Induced by Iron in Pediatric Inflammatory Bowel Disease

Gut resistome presents a unique biome signature in chronic multi-symptom illness patients and links persistent pro-inflammatory phenotype in a mouse model reversible by fecal microbiota transfer

Contact Info

Product

Resources

About