Interleukin‐6 as a prognostic marker in dogs in an intensive care unit

Abstract

The results of this study suggest that IL-6 is a useful prognostic marker for canine critical care patients with acute internal disease.

Serum alpha1‐proteinase inhibitor concentrations in dogs with systemic inflammatory response syndrome or sepsis

“…Proinflammatory cytokines IL‐6 and TNF‐α were also evaluated in this study. The increase in plasma IL‐6 concentration in dogs with SIRS/sepsis but its inability to differentiate septic dogs from those with noninfectious SIRS is consistent with previous studies in dogs but contrasts the results of other studies showing IL‐6 to have prognostic potential in dogs with SIRS/sepsis . Also, a cause‐and‐effect relationship between IL‐6 and cα 1 ‐PI cannot be confirmed based on the results of this study, as cytokines and APP can influence the expression and release of one another, and the signaling pathways involved in systemic inflammation and infection are complex and characterized by a moderate degree of redundancy …”

“…Proinflammatory cytokines such as interleukin‐6 (IL‐6), which induces mainly type II APPs, and tumor necrosis factor‐alpha (TNF‐α), which induces type I APPs, have been demonstrated to be upregulated in dogs with sepsis or noninfectious systemic inflammatory response syndrome (SIRS) but not to distinguish between them . C‐reactive protein (CRP), a type I APP of the pentraxin family, has been shown to have prognostic utility in dogs with sepsis or SIRS but also lacks the ability to discriminate sepsis from noninfectious SIRS …”

Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

“…Serum IL‐6 was measured using a commercially available canine Minneapolis, MN ELISA (Quantikine Canine IL‐6 immunoassay, R&D Systems), with a limit of detection (LOD) of 1.5 pg/mL. This assay has been fully validated in dogs . Serum CCL2 also was measured with a commercial canine ELISA (Quantikine Canine CCL2/MCP‐1 ELISA, R&D Systems; LOD of 1.4 pg/mL), as previously reported in dogs .…”

Köpeklerde Pyometranın Bazı Oksidatif Stres Parametreleri, İnflamatorik Mediyatörler ve Nötrofil Segmentasyonu Üzerine Etkileri

“…In that study, IL-6 level in bitches with pyometra similar with dogs with acute hepatitis and varied between 1-202 pg/ mL. In a newer study [28] revealed that, IL-6 concentrations were ranged from 45-4656 pg/mL in the non-surviving dogs while the surviving dogs had a range of 0-405 pg/mL in an intensive care unit. IL-6 found to be a good prognostic factor in critically ill dogs (P<0.001) but its concentrations in bitches with pyometra (a part of the survivors) were not given to the reader [28] .…”

“…In a newer study [28] revealed that, IL-6 concentrations were ranged from 45-4656 pg/mL in the non-surviving dogs while the surviving dogs had a range of 0-405 pg/mL in an intensive care unit. IL-6 found to be a good prognostic factor in critically ill dogs (P<0.001) but its concentrations in bitches with pyometra (a part of the survivors) were not given to the reader [28] . Our results of IL-6 concentrations within the accordance with this study, and none of the bitches died during the study.…”