Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People

Kurowska, Anna; Bodys-Cupak, Iwona; Staszkiewicz, Magdalena; Szklarczyk, Joanna; Zalewska-Puchała, Joanna; Kliś-Kalinowska, Anna; Makara‐Studzińska, Marta; Majda, Anna

doi:10.3390/ijerph17103623

Cited by 8 publications

(15 citation statements)

References 40 publications

(46 reference statements)

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“…Aging is characterized as a complex process, resulting from several interactions between biological, psychological, and social factors, which can contribute in different ways to trace different trajectories of aging. Indeed, each of these components may concur as a protective factor towards physiological, or even to a successful, aging, as well as a vulnerability factor that progressively exposes the individual to reduced independence [ 56 ] and increased risk of adverse age-related outcomes [ 57 , 58 , 59 , 60 ]. Therefore, the implementation of preventive strategies should be aimed at facing the consequences of the pandemic not only on the physical health of the elderly [ 61 ] but also on their HRQoL and their psychological wellbeing.…”

Section: Discussionmentioning

confidence: 99%

Expressive Flexibility and Dispositional Optimism Contribute to the Elderly’s Resilience and Health-Related Quality of Life during the COVID-19 Pandemic

Sardella

Lenzo

Bonanno

et al. 2021

IJERPH

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The COVID-19 outbreak had a negative impact on psychological status among elderly subjects, negatively affecting their health-related quality of life (HRQoL). Psychological factors that promote resilience might beneficially contribute also to promoting a better HRQoL among elderly subjects. The main purpose of the present study was to investigate the contribution of dispositional optimism and expressive flexibility on the HRQoL of elderly outpatients during the COVID-19 outbreak. The outpatients were recruited from October 2018 to October 2019, and then followed-up during April 2020, by evaluating their HRQoL. The baseline sample consisted of 141 elderly outpatients (mean age 80.31 ± 6.84 years); the final number of outpatients included in the follow-up evaluation was 104 (mean age 80.26 ± 6.39). Univariate and multivariate linear regressions were developed to explore significant associations with the physical and mental component of HRQoL. Baseline dispositional optimism was a predictor of the mental component of HRQoL at follow-up; the flexible suppression of emotional expression was a predictor of the physical component of HRQoL at follow-up. From a psychogeriatric perspective, the accurate assessment of psychological factors, such as dispositional optimism and expressive flexibility, might help physicians and psychologists to recognize additional patients’ vulnerabilities during the current emergency.

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Section: Discussionmentioning

confidence: 99%

Expressive Flexibility and Dispositional Optimism Contribute to the Elderly’s Resilience and Health-Related Quality of Life during the COVID-19 Pandemic

Sardella

Lenzo

Bonanno

et al. 2021

IJERPH

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show abstract

“…At the same time, another study showed that low serum melatonin was associated with autonomic neuropathy in type 2 diabetic patients and indicated that the circadian rhythm of melatonin secretion is blunted in type 2 diabetic patients [ 17 ]. Similarly, reduced melatonin was also associated with cognitive dysfunction in patients with Alzheimer's disease, schizophrenia, and even healthy older people [ 7 , 18 , 19 ]. However, it remains unclear about the association between serum melatonin and MCI in T2DM patients.…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study

Zhang

Zhu

et al. 2021

International Journal of Endocrinology

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Objectives. Melatonin is an essential neuroendocrine hormone that participates in the regulation of sleep rhythm and cognitive function. This study aimed to determine serum melatonin levels with mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM). Methods. A total of 247 T2DM patients were recruited in this retrospective study and divided into 75 subjects with MCI and 172 with normal cognition. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA). Their blood sample was examined for the level of melatonin and other biochemical parameters. Results. Melatonin concentration was decreased in MCI patients to non-MCI patients ( P < 0.001). Melatonin level was negatively correlated with age (r = −0.202; P = 0.001), diabetes duration (r = −0.282; P < 0.001), serum HbA1c (r = −0.195; P = 0.002), hs-CRP (r = −0.324; P < 0.001), and TSH (r = −0.184; P = 0.004) levels and positively correlated with MoCA score, serum HDL-C (r = 0.145; P < 0.001), FT3 (r = 0.241; P < 0.001), and FT4 (r = 0.169; P = 0.008) levels. The multivariable analysis indicated that fewer years of formal education, longer diabetes duration, higher serum HbA1c, higher serum hs-CRP, and lower serum melatonin are the predisposing factors for MCI. Conclusion. Lower melatonin level was associated with cognitive impairment in patients with T2DM. Melatonin might serve as a potential protective molecule against cognitive dysfunction in T2DM.

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“…In clinical studies, melatonin alleviates cognitive disturbance resulting from breast cancer chemotherapy ( 124 )). Recent advances have regarded melatonin as an index of cognitive impairment in elderly individuals ( 125 ). Moreover, melatonin has been shown to effectively improve cognitive deficits in AD mouse models ( 126 ).…”

Section: Melatonin Improves Mood and Cognitive Functionmentioning

confidence: 99%

Melatonin for premenstrual syndrome: A potential remedy but not ready

Yin

Zhang²,

Guo³

et al. 2023

Front. Endocrinol.

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Premenstrual syndrome (PMS), a recurrent and moderate disorder that occurs during the luteal phase of the menstrual cycle and quickly resolves after menstruation, is characterized by somatic and emotional discomfort that can be severe enough to impair daily activities. Current therapeutic drugs for PMS such as selective serotonin reuptake inhibitors are not very satisfying. As a critical pineal hormone, melatonin has increasingly been suggested to modulate PMS symptoms. In this review, we update the latest progress on PMS-induced sleep disturbance, mood changes, and cognitive impairment and provide possible pathways by which melatonin attenuates these symptoms. Moreover, we focus on the role of melatonin in PMS molecular mechanisms. Herein, we show that melatonin can regulate ovarian estrogen and progesterone, of which cyclic fluctuations contribute to PMS pathogenesis. Melatonin also modulates gamma-aminobutyric acid and the brain-derived neurotrophic factor system in PMS. Interpreting the role of melatonin in PMS is not only informative to clarify PMS etiology but also instructive to melatonin and its receptor agonist application to promote female health. As a safe interaction, melatonin treatment can be effective in alleviating symptoms of PMS. However, symptoms such as sleep disturbance, depressive mood, cognitive impairment are not specific and can be easily misdiagnosed. Connections between melatonin receptor, ovarian steroid dysfunction, and PMS are not consistent among past studies. Before final conclusions are drawn, more well-organized and rigorous studies are recommended.

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Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People

Cited by 8 publications

References 40 publications

Expressive Flexibility and Dispositional Optimism Contribute to the Elderly’s Resilience and Health-Related Quality of Life during the COVID-19 Pandemic

Expressive Flexibility and Dispositional Optimism Contribute to the Elderly’s Resilience and Health-Related Quality of Life during the COVID-19 Pandemic

Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study

Melatonin for premenstrual syndrome: A potential remedy but not ready

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