Interleukin-6 and leptin levels are associated with preoperative pain severity in patients with osteoarthritis but not with acute pain after total knee arthroplasty

Azim, Syed; Nicholson, James; Rebecchi, Mario J.; Galbavy, William; Tian, Feng; Rizwan, Sabeen; Reinsel, Ruth A.; Kaczocha, Martin; Benveniste, Helene

doi:10.1016/j.knee.2017.12.001

Cited by 30 publications

(23 citation statements)

References 36 publications

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“…Elevated BMI as well as preoperative existing pain have previously been reported to be associated with increased postoperative pain in different types of surgeries other than VATS 8,[13][14][15][16] . Our study was the first to demonstrate that these associations also present in patients undergoing VATS and that patients with high BMI and pre-existing pain deserved additional care.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, opioids such as sulfentanil as we used in this study were distributed at least as extensively in the excess body mass as in the lean tissues, therefore the same dose of opioids might be less effective in obese patients 18,19 . Additionally, obesity and preoperative pain were both characterized by elevated proinflammatory cytokines and subclinical systemic inflammation, leading to decreased pain threshold 15,[20][21][22] . Further study is needed to elucidate the potential mechanisms behind our observations.…”

Section: Discussionmentioning

confidence: 99%

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Moderate-severe postoperative pain in patients undergoing video-assisted thoracoscopic surgery: A retrospective study

Sun

Liu

Chen

et al. 2020

Sci Rep

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Moderate-severe pain after surgical procedures is associated with decreased quality of life and increased costs. this study aimed to identify the incidence and predictive factors of moderate-severe postoperative pain within 48 hours following video-assisted thoracoscopic surgery (VATS) in a tertiary hospital. A retrospective cohort analysis was performed using medical records of adult patients who underwent VATS between January 2015 and December 2016. Logistic regression was performed to identify predictive factors for moderate-severe pain (visual analogue scale, VAS ≥ 4) within 24 hours and within 48 hours postoperatively. Of the 1164 participants, the incidence of moderate-severe pain was 12.7% within the first 24 hours and 15.6% within the first 48 hours after surgery. In multivariable analysis, the independent risk factors related to moderate-severe pain within 24 hours after surgery were younger age, increased body mass index, preoperative pain within 1 month and history of smoking. The risk factors for moderate-severe acute pain within 48 hours were almost the same, except that the number of chest tubes were also included. Moderate-severe postoperative pain following VATS is not rare, and presence of several risk factors deserves more aggressive pain management strategies perioperatively. Moderate-severe pain after surgical procedures is associated with prolonged hospital stays, readmissions, patient dissatisfaction, development of chronic pain, decreased quality of life and increased costs 1,2. It is widely accepted that better management of postoperative pain results in better patients' recovery. Video assisted thoracoscopic surgery (VATS), compared to conventional thoracotomy, is notable for less tissue trauma, improved postoperative respiratory function, and increased tolerability for the patients 3. Although potentially less postoperative pain was generally expected as one of the benefits of VATS 4 , many patients still suffer moderate to severe pain postoperatively 2,5-7. There are several reasons contributing to this unsatisfactory situation, one of them being that some patients may have certain risk factors for occurrence of more severe postoperative pain 8. Early identification of patients at risk may help to allow early application of effective treatment strategies to prevent unexpected suffering in these patients. Previously, several studies have focused on the predictors of postoperative pain and demographic, social psychological and clinical factors have been identified contributing to the development of severe postoperative pain 5,6,8,9. However, most of them are cohorts with mixed surgical procedures while VATS is not included. Moreover, various subtypes of VATS (uniportal, multiportal and robotic) exist currently, and the lack of guideline results in variation of analgesia regimens and effectiveness of analgesia in different medical centers 10. To date, the predictive factors of moderate-severe postoperative pain following VATS were not reported, which is important for individual-specific pa...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Moderate-severe postoperative pain in patients undergoing video-assisted thoracoscopic surgery: A retrospective study

Sun

Liu

Chen

et al. 2020

Sci Rep

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“…Избыточная продукция ИЛ6 вызывает аутоимунные повреждения суставов при ревматоидном артрите и активирует остеокласты, осуществляющие деградацию костной ткани [16]. Повышенный уровень ИЛ6 также соотносится с усилением болевых реакций [17], так что ингибирование действия ИЛ6 посредством изученных НПВП соответствует обезболивающему эффекту. В целом НПВП существенно дополняют эффекты ГС при воздействии на уровень и активность провоспалительных цитокинов.…”

Section: о ц е н к и и н г и б и р о в а н и я б е л к о в м е т а б unclassified

Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations

Громова¹,

Торшин²,

Лила³

et al. 2018

RJTAO

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Глюкозамина сульфат (ГС) необходим для регенерации хрящевой ткани, кроме того, он обладает противовоспалительными свойствами, сравнимыми с таковыми нестероидных противовоспалительных препаратов (НПВП). Клинические исследования указывают на синергизм действия ГС и НПВП при остеоартрите (ОА) и при других заболеваниях суставов. Цель исследования-оценка степени синергизма различных комбинаций ГС и НПВП. Материал и методы. Проведен дифференциальный хемореактомный анализ эффектов ГС и семи средств класса НПВП (кеторолак, нимесулид, диклофенак, мелоксикам, декскетопрофен, целекоксиб, эторикоксиб) для определения степени синергизма различных комбинаций ГС и НПВП. Результаты и обсуждение. Показано, что декскетопрофен (и в меньшей степени кеторолак) наиболее эффективно усиливают противовоспалительные свойства ГС. Для использования на практике рекомендован следующий подход: на 1-й неделе лечения для быстрого устранения болевого синдрома назначается наиболее эффективная комбинация-ГС + декскетопрофен (либо ГС + кеторолак), после чего можно использовать комбинацию ГС с НПВП, прием которого в течение более длительного времени сопряжен с минимальными побочными эффектами. Выводы. Результаты исследования показали, что совместное использование ГС и НПВП при патологии суставов является перспективным.

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“…3,4 It has been suggested that high levels of proinflammatory cytokines including interleukins (IL-1β, IL-6, IL-18) as well as tumour necrosis factor α (TNF-α), trigger cartilage degeneration by increasing oxidative stress and metalloprotease activity. 5,6 Nonpharmacologic treatments of OA include exercise, weight loss, physical therapy, and rehabilitation. 7 For pain relief, pharmacologic treatments such as analgesics, nonsteroidal antiinflammatory drugs, and neuromodulators of pain can be used for patients with OA.…”

Section: Introductionmentioning

confidence: 99%

“…Osteoarthritis includes osteophyte formation, degradation of the articular cartilage, thickening of the subchondral bone, synovial inflammation, degeneration of ligaments, and changes in periarticular muscles, nerves, and bursae . It has been suggested that high levels of proinflammatory cytokines including interleukins (IL‐1β, IL‐6, IL‐18) as well as tumour necrosis factor α (TNF‐α), trigger cartilage degeneration by increasing oxidative stress and metalloprotease activity …”

Section: Introductionmentioning

confidence: 99%

Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

Arias‐Vázquez

Tovilla‐Zárate

Hernández‐Díaz

et al. 2019

PM&R

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Background Ozone therapy has been used widely to decrease pain related to osteoarthritis, but the effectiveness of this treatment has not been evaluated. Objective To evaluate the effectiveness of ozone therapy in the reduction of pain in patients with knee osteoarthritis, according to the type of intervention and duration of the effect. Type Meta‐analysis. Literature Survey We performed an online search using PUBMED, DIALNET, SCIELO, MEDIGRAPHIC, and ISCO3 databases. We searched for articles published up to January 2018. Participants We selected eight studies including a total of 355 patients and 363 controls. Methodology Only randomized‐controlled trials that assessed the efficacy of intraarticular or periarticular infiltrations with ozone to treat knee osteoarthritis in humans were included in the analysis. The results are expressed as standardized mean difference and 95% confidence intervals. The meta‐analysis was performed in accordance with the statement of Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. Synthesis We observed that ozone treatment had a therapeutic effect when compared with placebo (d = −0.81, 95% CI −1.06 to −0.55, I2 = 34.79, P(Q) = .47) or other noninvasive treatments. No significant effects were found in favor of the ozone treatment when compared with the use of hyaluronic acid or platelet‐rich plasma. However, the use of ozone had a significant short‐term benefit reducing knee pain (d = −2.26, 95% CI −2.26 to −3.72, I2 = 97, P(Q) < .001). Pain relief benefits lasted between 3 and 6 months. Conclusion Our results indicate that intraarticular infiltrations of ozone can be used as an optional effective treatment for the management of pain related to knee osteoarthritis. There are short‐term effect benefits that peak at around 1 month of treatment, with a gradual decline in efficacy after 3 to 6 months of treatment. More studies are needed to improve our understanding of the efficacy of this interventional treatment. Level of Evidence I

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Interleukin-6 and leptin levels are associated with preoperative pain severity in patients with osteoarthritis but not with acute pain after total knee arthroplasty

Cited by 30 publications

References 36 publications

Moderate-severe postoperative pain in patients undergoing video-assisted thoracoscopic surgery: A retrospective study

Moderate-severe postoperative pain in patients undergoing video-assisted thoracoscopic surgery: A retrospective study

Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations

Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

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